dbPTM

SPSY_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPSY_YEAST
UniProt AC	Q12455
Protein Name	Spermine synthase
Gene Name	SPE4
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	300
Subcellular Localization
Protein Description
Protein Sequence	MVNNSQHPYIKDGWFREINDKSFPGQAFTMTVDSILYEARSEFQDILIFRNKVYGTVLVLDGIVQCTEFDEFAYQEMITHIAMFAHSNPKRVLIIGGGDGGVLREVAKHSCVEDITMVEIDSSVIELSRKFLPTLSNGAFDDERLDLKLCDGFKFLQDIGASDVHKKFDVIITDSSDPEGPAEAFFQERYFELLKDALNPNGVVIMQSSENFWLNLKYLHDLKNTAKKVFPNTEYCYTMVPTYTSGQLGLIVCSNNANIPLNIPQRKISEQEQGKLKYYNPQIHSSAFVLPTWADKVINE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MVNNSQHPYIKD ---CCCCCCCCCCCC	25.35	22369663
9	Phosphorylation	VNNSQHPYIKDGWFR CCCCCCCCCCCCCEE	20.62	28132839
21	Ubiquitination	WFREINDKSFPGQAF CEEECCCCCCCCCEE	49.89	19722269
166	Acetylation	IGASDVHKKFDVIIT CCCCHHHHHCCEEEE	55.79	24489116
173	Phosphorylation	KKFDVIITDSSDPEG HHCCEEEECCCCCCC	20.78	30377154
175	Phosphorylation	FDVIITDSSDPEGPA CCEEEECCCCCCCHH	28.17	30377154
176	Phosphorylation	DVIITDSSDPEGPAE CEEEECCCCCCCHHH	61.05	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPSY_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPSY_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPSY_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPEE_YEAST	SPE3	physical	16554755
ELO2_YEAST	ELO2	genetic	21623372
THDH_YEAST	ILV1	genetic	21623372
C1TM_YEAST	MIS1	genetic	21623372
6PGD1_YEAST	GND1	genetic	21623372
PGLR_YEAST	PGU1	genetic	21623372
QCR2_YEAST	QCR2	genetic	21623372
GPP1_YEAST	GPP1	genetic	21623372
MET22_YEAST	MET22	genetic	21623372
DCOR_YEAST	SPE1	genetic	21623372
CHO2_YEAST	CHO2	genetic	21623372
FOLE_YEAST	MET7	genetic	21623372
KIN82_YEAST	KIN82	genetic	27708008
DCOR_YEAST	SPE1	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
PANK_YEAST	CAB1	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
NTR2_YEAST	NTR2	genetic	27708008
NSE5_YEAST	NSE5	genetic	27708008
ORC1_YEAST	ORC1	genetic	27708008
XRN2_YEAST	RAT1	genetic	27708008
RPB2_YEAST	RPB2	genetic	27708008
GPN2_YEAST	GPN2	genetic	27708008
TF2B_YEAST	SUA7	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008
LTE1_YEAST	LTE1	genetic	27708008
SGF29_YEAST	SGF29	genetic	27708008
PRTD_YEAST	PRD1	genetic	27708008
SNT1_YEAST	SNT1	genetic	27708008
ATG15_YEAST	ATG15	genetic	27708008
PP2C1_YEAST	PTC1	genetic	27708008
TGL2_YEAST	TGL2	genetic	27708008
NBP2_YEAST	NBP2	genetic	27708008
MAL12_YEAST	MAL12	genetic	27708008
RL8A_YEAST	RPL8A	genetic	27708008
MED20_YEAST	SRB2	genetic	27708008
PTH_YEAST	PTH1	genetic	27708008
SA190_YEAST	SAP190	genetic	27708008
SET3_YEAST	SET3	genetic	27708008
RL6B_YEAST	RPL6B	genetic	27708008
PET8_YEAST	PET8	genetic	27708008
WHI5_YEAST	WHI5	genetic	27708008
LGE1_YEAST	LGE1	genetic	27708008
NCBP2_YEAST	CBC2	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPSY_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, AND MASSSPECTROMETRY.	18407956 [Abstract]