SA190_YEAST - dbPTM
SA190_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SA190_YEAST
UniProt AC P36123
Protein Name SIT4-associating protein SAP190
Gene Name SAP190
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1033
Subcellular Localization Cytoplasm .
Protein Description Positive regulator of protein phosphatase SIT4. Involved in the general amino acid control (GAAC) response regulated by TOR. Involved in the dephosphorylation of the elongator complex subunit IKI3..
Protein Sequence MSGSFWKFGQDYSIESPVSKILNSAFIKINKDQDDDVPTGTCEENIADDEDNSSHDYAASEDNVVNENEEKEEENTLPTTESEYENYRPNLDVLDDLLDDDELYTELMCSNFKLLIFLKYPDVLSKLIEYVTNEKILDEETDSAKKPEIIEGVNDHPILIERDRKDKKEDAEEGGDSEETTNDSDHDSGDERSVDSEETSITLPPESEEQVETRRARIAAEILSADVWPISAAIMQNKDLLGRLWSILDHPAPLPIPASTYFMKINERLLDMDITGMLEFILSRDSLVARFLTHVDNPSLMDFLLKVISTDKPDSPTGVIKILKSQELIPKLLDHLNPEYGISTQSAAGDFIKAFVTLSTNSSNELASGIGPNELTRQLVSEEMIEKLIKIMLKGGTSLSNGVGIIIELIRKNNSDYDFIQLVYTTLESHPPTDRDPIHLIHLVKLFAKHMPDFADMLDKTKLPLMEMPFGNIEPLGFERFKICELIAELLHCSNMTLLNEPNGEMIAQERDIERAKELETSTEKENITAIVDNKSSYYDKDCVEKDITENLGALQINNQGSEEDELNDTGVSSVKLDVKSDAKVVEGLENDASGVELYDETLSDTESVRECLREKPLVGDRLKIALEDTKILISILDMFTEFPWNNFLHNVIFDIAQQIFNGPLKTGYNRFLLKDYLVDAYLTKKIVDADKACQDYEKKTGLRYGYMGHLTLVAEEISKFKEYIDEMKLTFCNTAVSDRLEEPFWKEYSETILADTREKYNTVLGDFGNDQESDDDVIRNSDSEDIIGDTEGNENYGNGENDELLSNGHDSGNMDLYYNFNNNENEENEEDYAEYSDVDNKNYYNNVETNDDDYDSDDGKSKSAESEFTDKISEHRDGNSLYNEDNDENGSDKWTSGTSLFPPDHFPSRSQPSDPKLQDQNIFHHQFDFEGVGDDDDYMDPNDDGQSYARPGNPLYTTPKTPPRPKTILFNSLSALDNNGEDEEVALGTSVDDRMDNEISSDEEDSEDEDEENDMGNEEGYSLYRSRSKEAF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSGSFWKFG
------CCCCCHHCC		55.2227717283
4Phosphorylation----MSGSFWKFGQD
----CCCCCHHCCCC		36.9115665377
7Ubiquitination-MSGSFWKFGQDYSI
-CCCCCHHCCCCCCC		37.2924961812
39PhosphorylationDQDDDVPTGTCEENI
CCCCCCCCCCCCCCC		45.0021551504
41PhosphorylationDDDVPTGTCEENIAD
CCCCCCCCCCCCCCC		21.1521551504
53PhosphorylationIADDEDNSSHDYAAS
CCCCCCCCCCCCCCC		41.1821551504
60PhosphorylationSSHDYAASEDNVVNE
CCCCCCCCCCCCCCC		36.9919779198
143PhosphorylationILDEETDSAKKPEII
CCCCCCCCCCCCHHH		49.7821440633
145UbiquitinationDEETDSAKKPEIIEG
CCCCCCCCCCHHHCC		73.2023749301
146UbiquitinationEETDSAKKPEIIEGV
CCCCCCCCCHHHCCC		47.8224961812
177PhosphorylationDAEEGGDSEETTNDS
HHHCCCCCCCCCCCC		40.3819779198
184PhosphorylationSEETTNDSDHDSGDE
CCCCCCCCCCCCCCC		38.6328889911
188PhosphorylationTNDSDHDSGDERSVD
CCCCCCCCCCCCCCC		44.7328889911
312UbiquitinationLKVISTDKPDSPTGV
HHHHCCCCCCCCCCH		51.3023749301
536PhosphorylationTAIVDNKSSYYDKDC
EEEECCCCCCCCHHH		29.8124961812
537PhosphorylationAIVDNKSSYYDKDCV
EEECCCCCCCCHHHH		29.3524961812
580UbiquitinationSSVKLDVKSDAKVVE
CEEEEEECCCCCHHH		42.1423749301
581PhosphorylationSVKLDVKSDAKVVEG
EEEEEECCCCCHHHC		42.5228889911
594PhosphorylationEGLENDASGVELYDE
HCCCCCCCCCEEECC		46.3519823750
599PhosphorylationDASGVELYDETLSDT
CCCCCEEECCCCCCH		9.7621440633
602PhosphorylationGVELYDETLSDTESV
CCEEECCCCCCHHHH		28.7620377248
604PhosphorylationELYDETLSDTESVRE
EEECCCCCCHHHHHH		50.3220377248
606PhosphorylationYDETLSDTESVRECL
ECCCCCCHHHHHHHH		27.1220377248
608PhosphorylationETLSDTESVRECLRE
CCCCCHHHHHHHHHH		28.6820377248
675UbiquitinationGYNRFLLKDYLVDAY
CCCHHHHHHHHHHHH		46.6124961812
761PhosphorylationLADTREKYNTVLGDF
HHHHHHHHHCCCCCC		16.0019779198
774PhosphorylationDFGNDQESDDDVIRN
CCCCCCCCCCCCHHC		40.4822369663
844PhosphorylationSDVDNKNYYNNVETN
CCCCCCCCCCCCCCC		14.8029136822
845PhosphorylationDVDNKNYYNNVETND
CCCCCCCCCCCCCCC		15.0629136822
850PhosphorylationNYYNNVETNDDDYDS
CCCCCCCCCCCCCCC		39.4029136822
855PhosphorylationVETNDDDYDSDDGKS
CCCCCCCCCCCCCCC		25.0925521595
857PhosphorylationTNDDDYDSDDGKSKS
CCCCCCCCCCCCCCC		31.2222369663
862PhosphorylationYDSDDGKSKSAESEF
CCCCCCCCCCCHHHH		37.0519823750
864PhosphorylationSDDGKSKSAESEFTD
CCCCCCCCCHHHHHH		44.3421440633
867PhosphorylationGKSKSAESEFTDKIS
CCCCCCHHHHHHHHH		37.4128889911
870PhosphorylationKSAESEFTDKISEHR
CCCHHHHHHHHHCCC		32.1229688323
874PhosphorylationSEFTDKISEHRDGNS
HHHHHHHHCCCCCCC		32.8419823750
881PhosphorylationSEHRDGNSLYNEDND
HCCCCCCCCCCCCCC		37.4519823750
883PhosphorylationHRDGNSLYNEDNDEN
CCCCCCCCCCCCCCC		19.1419823750
892PhosphorylationEDNDENGSDKWTSGT
CCCCCCCCCCCCCCC		47.8228889911
914PhosphorylationFPSRSQPSDPKLQDQ
CCCCCCCCCCCCCCC		59.9328889911
939PhosphorylationGVGDDDDYMDPNDDG
CCCCCCCCCCCCCCC		15.4819823750
948PhosphorylationDPNDDGQSYARPGNP
CCCCCCCCCCCCCCC		26.7019823750
949PhosphorylationPNDDGQSYARPGNPL
CCCCCCCCCCCCCCC		9.9519823750
957PhosphorylationARPGNPLYTTPKTPP
CCCCCCCCCCCCCCC		15.1519823750
958PhosphorylationRPGNPLYTTPKTPPR
CCCCCCCCCCCCCCC		44.2819823750
959PhosphorylationPGNPLYTTPKTPPRP
CCCCCCCCCCCCCCC		14.8319823750
962PhosphorylationPLYTTPKTPPRPKTI
CCCCCCCCCCCCCEE		39.4619823750
990PhosphorylationDEEVALGTSVDDRMD
CCCHHHCCCCCHHHC		26.8228889911
991PhosphorylationEEVALGTSVDDRMDN
CCHHHCCCCCHHHCC		23.0428889911
1027PhosphorylationEGYSLYRSRSKEAF-
HHHHHHHHCCCCCC-		27.6128889911
1029PhosphorylationYSLYRSRSKEAF---
HHHHHHCCCCCC---		35.7728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SA190_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SA190_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SA190_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SAP4_YEASTSAP4genetic
15367655
SA155_YEASTSAP155genetic
15367655
SA185_YEASTSAP185genetic
17314980
SUS1_YEASTSUS1genetic
17314980
NOT2_YEASTCDC36genetic
17314980
PRI1_YEASTPRI1genetic
17314980
MTC4_YEASTMTC4genetic
17314980
RGP1_YEASTRGP1genetic
17314980
PLMT_YEASTOPI3genetic
17314980
ISC1_YEASTISC1genetic
17314980
FUS3_YEASTFUS3genetic
19269370
CKS1_YEASTCKS1genetic
19269370
BEM1_YEASTBEM1genetic
19269370
GCN2_YEASTGCN2genetic
19269370
ISC1_YEASTISC1genetic
19269370
GET2_YEASTGET2genetic
19269370
BMH1_YEASTBMH1genetic
19269370
BUB1_YEASTBUB1genetic
19269370
SA185_YEASTSAP185genetic
19269370
PLMT_YEASTOPI3genetic
19269370
RIC1_YEASTRIC1genetic
19269370
YPT6_YEASTYPT6genetic
19269370
SEC22_YEASTSEC22genetic
19269370
BRE5_YEASTBRE5genetic
19269370
HRK1_YEASTHRK1genetic
19269370
PP11_YEASTSIT4physical
19749176
SA155_YEASTSAP155genetic
19749176
SED5_YEASTSED5genetic
27708008
HXT10_YEASTHXT10genetic
27708008
KCC1_YEASTCMK1genetic
27708008
OSW7_YEASTOSW7genetic
27708008
TIM21_YEASTTIM21genetic
27708008
CG21_YEASTCLB1genetic
27708008
CHO2_YEASTCHO2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
MET22_YEASTMET22genetic
27708008
CND2_YEASTBRN1genetic
27708008
APC11_YEASTAPC11genetic
27708008
FAL1_YEASTFAL1genetic
27708008
MAK21_YEASTMAK21genetic
27708008
LCB2_YEASTLCB2genetic
27708008
SC61G_YEASTSSS1genetic
27708008
SEC20_YEASTSEC20genetic
27708008
ACT_YEASTACT1genetic
27708008
NBP35_YEASTNBP35genetic
27708008
GWT1_YEASTGWT1genetic
27708008
SMC4_YEASTSMC4genetic
27708008
LCB1_YEASTLCB1genetic
27708008
LIP1_YEASTLIP1genetic
27708008
CH10_YEASTHSP10genetic
27708008
NAB3_YEASTNAB3genetic
27708008
ARP7_YEASTARP7genetic
27708008
GPT1_YEASTSCT1genetic
27708008
RU1A_YEASTMUD1genetic
27708008
APE3_YEASTAPE3genetic
27708008
ELO2_YEASTELO2genetic
27708008
MTU1_YEASTSLM3genetic
27708008
CRD1_YEASTCRD1genetic
27708008
UBC5_YEASTUBC5genetic
27708008
PAC11_YEASTPAC11genetic
27708008
SNA2_YEASTSNA2genetic
27708008
SWP82_YEASTSWP82genetic
27708008
YFJ0_YEASTYFR020Wgenetic
27708008
TYW3_YEASTTYW3genetic
27708008
YPS5_YEASTYPS5genetic
27708008
PEX31_YEASTPEX31genetic
27708008
ACBP_YEASTACB1genetic
27708008
ASK10_YEASTASK10genetic
27708008
YIC9_YEASTYIL029Cgenetic
27708008
YAK1_YEASTYAK1genetic
27708008
ELO1_YEASTELO1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
IME1_YEASTIME1genetic
27708008
UPS2_YEASTUPS2genetic
27708008
ELO3_YEASTELO3genetic
27708008
ERG5_YEASTERG5genetic
27708008
PET8_YEASTPET8genetic
27708008
MDM12_YEASTMDM12genetic
27708008
ALG6_YEASTALG6genetic
27708008
ALG8_YEASTALG8genetic
27708008
RTC6_YEASTRTC6genetic
27708008
ELP3_YEASTELP3genetic
28357221
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SA190_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-581; THR-606 ANDSER-774, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774 AND SER-857, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774 AND SER-857, ANDMASS SPECTROMETRY.

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