GPT1_YEAST - dbPTM
GPT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPT1_YEAST
UniProt AC P32784
Protein Name Glycerol-3-phosphate O-acyltransferase 1
Gene Name SCT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 759
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase..
Protein Sequence MPAPKLTEKFASSKSTQKTTNYSSIEAKSVKTSADQAYIYQEPSATKKILYSIATWLLYNIFHCFFREIRGRGSFKVPQQGPVIFVAAPHANQFVDPVILMGEVKKSVNRRVSFLIAESSLKQPPIGFLASFFMAIGVVRPQDNLKPAEGTIRVDPTDYKRVIGHDTHFLTDCMPKGLIGLPKSMGFGEIQSIESDTSLTLRKEFKMAKPEIKTALLTGTTYKYAAKVDQSCVYHRVFEHLAHNNCIGIFPEGGSHDRTNLLPLKAGVAIMALGCMDKHPDVNVKIVPCGMNYFHPHKFRSRAVVEFGDPIEIPKELVAKYHNPETNRDAVKELLDTISKGLQSVTVTCSDYETLMVVQTIRRLYMTQFSTKLPLPLIVEMNRRMVKGYEFYRNDPKIADLTKDIMAYNAALRHYNLPDHLVEEAKVNFAKNLGLVFFRSIGLCILFSLAMPGIIMFSPVFILAKRISQEKARTALSKSTVKIKANDVIATWKILIGMGFAPLLYIFWSVLITYYLRHKPWNKIYVFSGSYISCVIVTYSALIVGDIGMDGFKSLRPLVLSLTSPKGLQKLQKDRRNLAERIIEVVNNFGSELFPDFDSAALREEFDVIDEEEEDRKTSELNRRKMLRKQKIKRQEKDSSSPIISQRDNHDAYEHHNQDSDGVSLVNSDNSLSNIPLFSSTFHRKSESSLASTSVAPSSSSEFEVENEILEEKNGLASKIAQAVLNKRIGENTAREEEEEEEEEEEEEEEEEEGKEGDA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MPAPKLTEKFASSK
-CCCCHHHHHHHCCC		43.1628889911
13PhosphorylationLTEKFASSKSTQKTT
HHHHHHCCCCCCCCC		27.4828889911
223AcetylationLLTGTTYKYAAKVDQ
HHHCCHHHHEEECCH		26.7324489116
509PhosphorylationPLLYIFWSVLITYYL
HHHHHHHHHHHHHHH		9.0430377154
513PhosphorylationIFWSVLITYYLRHKP
HHHHHHHHHHHHCCC		11.2730377154
514PhosphorylationFWSVLITYYLRHKPW
HHHHHHHHHHHCCCC		8.1030377154
515PhosphorylationWSVLITYYLRHKPWN
HHHHHHHHHHCCCCC		6.6530377154
639PhosphorylationIKRQEKDSSSPIISQ
HHHHCCCCCCCCCCC		43.7328889911
640PhosphorylationKRQEKDSSSPIISQR
HHHCCCCCCCCCCCC		50.7122369663
641PhosphorylationRQEKDSSSPIISQRD
HHCCCCCCCCCCCCC		24.8722369663
645PhosphorylationDSSSPIISQRDNHDA
CCCCCCCCCCCCCCC		21.6329688323
686PhosphorylationSSTFHRKSESSLAST
EEECCCCCCCCCCCC		42.5419779198
688PhosphorylationTFHRKSESSLASTSV
ECCCCCCCCCCCCCC		37.4327017623
689PhosphorylationFHRKSESSLASTSVA
CCCCCCCCCCCCCCC		24.7319779198
692PhosphorylationKSESSLASTSVAPSS
CCCCCCCCCCCCCCC		26.8919779198
693PhosphorylationSESSLASTSVAPSSS
CCCCCCCCCCCCCCC		22.9319779198
694PhosphorylationESSLASTSVAPSSSS
CCCCCCCCCCCCCCC		17.4919779198
698PhosphorylationASTSVAPSSSSEFEV
CCCCCCCCCCCCCHH		32.8721440633
699PhosphorylationSTSVAPSSSSEFEVE
CCCCCCCCCCCCHHH		36.5020377248
700PhosphorylationTSVAPSSSSEFEVEN
CCCCCCCCCCCHHHH		37.9220377248
701PhosphorylationSVAPSSSSEFEVENE
CCCCCCCCCCHHHHH		48.5321440633
733PhosphorylationNKRIGENTAREEEEE
HHHHCCCCCCHHHHH		23.8423749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GPT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GPT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GPT2_YEASTGPT2genetic
16269340
GET2_YEASTGET2genetic
16269340
DGK1_YEASTDGK1genetic
16269340
PMA1_YEASTPMA1genetic
16269340
SCS7_YEASTSCS7genetic
16269340
SEC22_YEASTSEC22genetic
16269340
BFR1_YEASTBFR1genetic
16269340
OSTB_YEASTWBP1genetic
16269340
RGP1_YEASTRGP1genetic
16269340
CHO2_YEASTCHO2genetic
16269340
RER2_YEASTRER2physical
18467557
KIN28_YEASTKIN28physical
21460040
SPO14_YEASTSPO14genetic
12167660
GPT2_YEASTGPT2genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
ATPO_YEASTATP5genetic
21623372
SCS7_YEASTSCS7genetic
21623372
ACO1_YEASTOLE1genetic
22323296
ACBP_YEASTACB1genetic
22323296
CST26_YEASTCST26genetic
22323296
ENO2_YEASTENO2physical
22940862
LDH1_YEASTLDH1genetic
23891562
UBX2_YEASTUBX2genetic
23891562
GPT2_YEASTGPT2genetic
23891562
ALG6_YEASTALG6genetic
23891562
ALG8_YEASTALG8genetic
23891562
GET2_YEASTGET2genetic
23891562
SRO7_YEASTSRO7genetic
23891562
ERG26_YEASTERG26genetic
23891562
MSMO_YEASTERG25genetic
23891562
DGK1_YEASTDGK1genetic
23891562
SMP3_YEASTSMP3genetic
27708008
RCY1_YEASTRCY1genetic
27708008
YRA2_YEASTYRA2genetic
27708008
UBR2_YEASTUBR2genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
INO4_YEASTINO4genetic
27708008
UPPS_YEASTNUS1genetic
27708008
GLE1_YEASTGLE1genetic
27708008
SEC20_YEASTSEC20genetic
27708008
COG3_YEASTCOG3genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRS8_YEASTRPT6genetic
27708008
TEL2_YEASTTEL2genetic
27708008
CP51_YEASTERG11genetic
27708008
MPPA_YEASTMAS2genetic
27708008
YKT6_YEASTYKT6genetic
27708008
RSC4_YEASTRSC4genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
STT4_YEASTSTT4genetic
27708008
CDC25_YEASTCDC25genetic
27708008
SC61A_YEASTSEC61genetic
27708008
ARP9_YEASTARP9genetic
27708008
TIM23_YEASTTIM23genetic
27708008
UFE1_YEASTUFE1genetic
27708008
ELO2_YEASTELO2genetic
27708008
SLX5_YEASTSLX5genetic
27708008
ARO1_YEASTARO1genetic
27708008
REXO1_YEASTRNH70genetic
27708008
BCK1_YEASTBCK1genetic
27708008
RPA34_YEASTRPA34genetic
27708008
PRY2_YEASTPRY2genetic
27708008
GPT2_YEASTGPT2genetic
27708008
SEI1_YEASTFLD1genetic
27708008
YL413_YEASTINA1genetic
27708008
ATG3_YEASTATG3genetic
27708008
MDM12_YEASTMDM12genetic
27708008
YO159_YEASTYOL159Cgenetic
27708008
SUCA_YEASTLSC1genetic
27708008
DGK1_YEASTDGK1genetic
27708008
WDR6_YEASTRTT10genetic
27708008
MRN1_YEASTMRN1genetic
27708008
PCL8_YEASTPCL8genetic
27708008
KAR3_YEASTKAR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPT1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, AND MASSSPECTROMETRY.

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