| UniProt ID | OSTB_YEAST | |
|---|---|---|
| UniProt AC | P33767 | |
| Protein Name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1 | |
| Gene Name | WBP1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 430 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein. |
|
| Protein Description | Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.. | |
| Protein Sequence | MRTDWNFFFCILLQAIFVVGTQTSRTLVLYDQSTEPLEEYSVYLKDLEQRNYKLEYLDINSTSTTVDLYDKEQRLFDNIIVFPTKGGKNLARQIPVKQLIKFFENEGNILCMSSPGAVPNTIRLFLNELGIYPSPKGHVIRDYFSPSSEELVVSSNHLLNKYVYNARKSEDFVFGESSAALLENREQIVPILNAPRTSFTESKGKCNSWTSGSQGFLVVGFQNLNNARLVWIGSSDFLKNKNQDSNQEFAKELLKWTFNEKSVIKSVHAVHSHADGTSYDEEPYKIKDKVIYSVGFSEWNGEEWLPHIADDIQFELRQVDPYYRLTLSPSGNDSETQYYTTGEFILPDRHGVFTFLTDYRKIGLSFTTDKDVKAIRHLANDEYPRSWEISNSWVYISAICGVIVAWIFFVVSFVTTSSVGKKLETFKKTN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Ubiquitination | EEYSVYLKDLEQRNY HHHEEEEHHHHHCCC | 42.45 | 15699485 | |
| 60 | N-linked_Glycosylation | KLEYLDINSTSTTVD EEEEEECCCCCCEEE | 38.61 | 29301962 | |
| 85 | Ubiquitination | NIIVFPTKGGKNLAR EEEEEECCCCHHHHH | 66.94 | 23749301 | |
| 88 | Ubiquitination | VFPTKGGKNLARQIP EEECCCCHHHHHHCC | 58.41 | 22817900 | |
| 101 | Ubiquitination | IPVKQLIKFFENEGN CCHHHHHHHHHHCCC | 53.22 | 17644757 | |
| 136 | Ubiquitination | LGIYPSPKGHVIRDY CCCCCCCCCCEEECC | 67.02 | 23749301 | |
| 161 | Ubiquitination | SSNHLLNKYVYNARK ECHHHHHHHHHHCCC | 35.74 | 17644757 | |
| 168 | Ubiquitination | KYVYNARKSEDFVFG HHHHHCCCCCCCCCC | 56.65 | 23749301 | |
| 203 | Ubiquitination | RTSFTESKGKCNSWT CCCCCCCCCCCCCCC | 57.04 | 23749301 | |
| 239 | Acetylation | IGSSDFLKNKNQDSN EECHHHHHCCCCCCC | 66.91 | 24489116 | |
| 239 | Ubiquitination | IGSSDFLKNKNQDSN EECHHHHHCCCCCCC | 66.91 | 22817900 | |
| 241 | Ubiquitination | SSDFLKNKNQDSNQE CHHHHHCCCCCCCHH | 55.16 | 23749301 | |
| 251 | Ubiquitination | DSNQEFAKELLKWTF CCCHHHHHHHHHHHC | 54.97 | 15699485 | |
| 251 | Acetylation | DSNQEFAKELLKWTF CCCHHHHHHHHHHHC | 54.97 | 24489116 | |
| 255 | Acetylation | EFAKELLKWTFNEKS HHHHHHHHHHCCCHH | 57.73 | 24489116 | |
| 255 | Ubiquitination | EFAKELLKWTFNEKS HHHHHHHHHHCCCHH | 57.73 | 15699485 | |
| 261 | Ubiquitination | LKWTFNEKSVIKSVH HHHHCCCHHHHHEEE | 51.64 | 23749301 | |
| 261 | Acetylation | LKWTFNEKSVIKSVH HHHHCCCHHHHHEEE | 51.64 | 24489116 | |
| 265 | Ubiquitination | FNEKSVIKSVHAVHS CCCHHHHHEEEEEEC | 44.24 | 17644757 | |
| 285 | Ubiquitination | SYDEEPYKIKDKVIY CCCCCCCCCCCEEEE | 54.73 | 17644757 | |
| 287 | Ubiquitination | DEEPYKIKDKVIYSV CCCCCCCCCEEEEEE | 47.55 | 17644757 | |
| 289 | Ubiquitination | EPYKIKDKVIYSVGF CCCCCCCEEEEEECC | 26.06 | 17644757 | |
| 332 | N-linked_Glycosylation | LTLSPSGNDSETQYY EEECCCCCCCCCEEE | 54.71 | 29301962 | |
| 370 | Ubiquitination | GLSFTTDKDVKAIRH CCEECCCHHHHHHHH | 63.43 | 24961812 | |
| 370 | Acetylation | GLSFTTDKDVKAIRH CCEECCCHHHHHHHH | 63.43 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OSTB_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OSTB_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OSTB_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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