NAB6_YEAST - dbPTM
NAB6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NAB6_YEAST
UniProt AC Q03735
Protein Name RNA-binding protein NAB6
Gene Name NAB6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1134
Subcellular Localization Cytoplasm .
Protein Description RNA-binding protein that associates with mRNAs encoding cell wall proteins..
Protein Sequence MSNSNSKKPVANYAYRQQQDYNGMNAMVGNPMMYHPVDFVNGAGQYGPSQHPAYYTNSPLPNIPPTPFDTAYGASLFPSHLLMGSPFVSSPNMQSGYNSARSSNLKRKAYSRPVSNHNGYNGNSNSNQNNTNNGMVTPSNYYRMGRNSFSRNNNSTRNVTHNNNKGCDTRNNSGRRTFARNNIFDDILPEMLLQRPFCINYKVLPTGDDAYRTRSLLIENVDHSIDLHSIVKNFVKSNTLESAYLIEGGKSDDSKDVETKNLSILISFLTKGDCLNFYNNILQRLSEFKTFLKSEALNLKFVCLNYDPKCLPTFIESEALTENAEEADITNGSTMISASLHHNIANKDATRSIIIEFKSPVEKSDLFKKKLQFLDRSKNKRYILESIDLVNTDVPSNQFPENYAVLTFLNISMAIEVLDYLKKYSKNLGISKCFYVSLAPLVVSSARSSVANIYEGKTSTHRLSVPSVTAGNNNDSNNNGNNNKSNMSGITTLNNNSSIGVSVYGHSNMSLTSLSSSVSLNEEIDMLATKLQGVELDGTYLEINYRDYQTPTIEEHSTHLSNVKISKTTENSRQFSQDIPSPLPLNEHMFMNDSNQSNGAIIPQQLIATPSPVSPNLQMNQRVLPNPITQSLEQNFNVSAKVASSMGSDIGNRTIYIGNINPRSKAEDICNVVRGGILQSIKYIPEKKICFVTFIEAPSAVQFYANSFIDPIVLHGNMLRVGWGHYSGPLPKLISLAVTIGASRNVYVSLPEFAFKEKFIHDPQYKKLHETLSLPDAEQLREDFSTYGDIEQINYLSDSHCCWINFMNISSAISLVEEMNKESTVQNESGEVTLKRATEEKFGGRYKGLLINYGKDRCGNINKNLIAGKNSRFYKKVKRPSYNIRLSKLEEKRRQNEIDEKEKAFDKPLNLESLGISLDAHKDNGGGETGTANNTGHENESELEAENENGNETGSFGGLGLAVASSDVKRATSDETDYEDIFNKSSGSSDSSSDVEVIMHSPSDPEYALKSQTLRSSSQTVINSKRPVKIEDEEEAVGMSQLNYRSSLRQAPPRAPSTLSYNHSKNNETPMQDIFTNGETANNRKKKRGSFARHRTIPGSDVMAQYLAQVQHSTFMYAANILGASAEDNTHPDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSNSNSKKP
------CCCCCCCCC		61.3422814378
4Phosphorylation----MSNSNSKKPVA
----CCCCCCCCCCC		52.3419779198
13PhosphorylationSKKPVANYAYRQQQD
CCCCCCHHHHHHCCC		8.6919779198
148PhosphorylationYYRMGRNSFSRNNNS
HHCCCCCCCCCCCCC		24.2021440633
267PhosphorylationKNLSILISFLTKGDC
CCHHHHHHHCCCCCH		15.6824909858
270PhosphorylationSILISFLTKGDCLNF
HHHHHHCCCCCHHHH		30.8524909858
363AcetylationEFKSPVEKSDLFKKK
EECCCCCCHHHHHHH		49.8824489116
437PhosphorylationISKCFYVSLAPLVVS
CCCCEEEEHHHHHHH		13.8730377154
444PhosphorylationSLAPLVVSSARSSVA
EHHHHHHHCCCHHHC		15.7120377248
445PhosphorylationLAPLVVSSARSSVAN
HHHHHHHCCCHHHCH		18.9828152593
448PhosphorylationLVVSSARSSVANIYE
HHHHCCCHHHCHHHC		28.9622369663
449PhosphorylationVVSSARSSVANIYEG
HHHCCCHHHCHHHCC		21.5022369663
454PhosphorylationRSSVANIYEGKTSTH
CHHHCHHHCCCCCCE		20.5919779198
458PhosphorylationANIYEGKTSTHRLSV
CHHHCCCCCCEEEEC		50.1121440633
459PhosphorylationNIYEGKTSTHRLSVP
HHHCCCCCCEEEECC		26.2128889911
460PhosphorylationIYEGKTSTHRLSVPS
HHCCCCCCEEEECCE		19.0819823750
464PhosphorylationKTSTHRLSVPSVTAG
CCCCEEEECCEEECC		31.7517330950
467PhosphorylationTHRLSVPSVTAGNNN
CEEEECCEEECCCCC		29.9119823750
469PhosphorylationRLSVPSVTAGNNNDS
EEECCEEECCCCCCC		32.9321440633
476PhosphorylationTAGNNNDSNNNGNNN
ECCCCCCCCCCCCCC		43.5119823750
497PhosphorylationITTLNNNSSIGVSVY
EEECCCCCEEEEEEE		26.0028889911
614PhosphorylationIATPSPVSPNLQMNQ
CCCCCCCCCCCCCCC		16.0828889911
874PhosphorylationAGKNSRFYKKVKRPS
CCCCCHHHHHCCCCC		14.5921440633
881PhosphorylationYKKVKRPSYNIRLSK
HHHCCCCCHHCCHHH		34.5421440633
882PhosphorylationKKVKRPSYNIRLSKL
HHCCCCCHHCCHHHH		19.7919823750
887PhosphorylationPSYNIRLSKLEEKRR
CCHHCCHHHHHHHHH		25.9121440633
907AcetylationEKEKAFDKPLNLESL
HHHHHHCCCCCHHHC		44.9724489116
929PhosphorylationKDNGGGETGTANNTG
CCCCCCCCCCCCCCC		43.0124961812
931PhosphorylationNGGGETGTANNTGHE
CCCCCCCCCCCCCCC		33.3621551504
935PhosphorylationETGTANNTGHENESE
CCCCCCCCCCCCHHH		39.4620377248
941PhosphorylationNTGHENESELEAENE
CCCCCCHHHHEEECC		60.0921440633
955PhosphorylationENGNETGSFGGLGLA
CCCCCCCCCCHHHHH		28.3021551504
972PhosphorylationSSDVKRATSDETDYE
CCCCCCCCCCCCCHH		40.5224961812
973PhosphorylationSDVKRATSDETDYED
CCCCCCCCCCCCHHH		32.2521440633
976PhosphorylationKRATSDETDYEDIFN
CCCCCCCCCHHHHHC		49.2028889911
985PhosphorylationYEDIFNKSSGSSDSS
HHHHHCCCCCCCCCC		40.8223749301
986PhosphorylationEDIFNKSSGSSDSSS
HHHHCCCCCCCCCCC		44.2821551504
988PhosphorylationIFNKSSGSSDSSSDV
HHCCCCCCCCCCCCE		32.6822369663
989PhosphorylationFNKSSGSSDSSSDVE
HCCCCCCCCCCCCEE		45.0722369663
991PhosphorylationKSSGSSDSSSDVEVI
CCCCCCCCCCCEEEE		33.4220377248
992PhosphorylationSSGSSDSSSDVEVIM
CCCCCCCCCCEEEEE		35.2320377248
993PhosphorylationSGSSDSSSDVEVIMH
CCCCCCCCCEEEEEE		50.0222369663
1001PhosphorylationDVEVIMHSPSDPEYA
CEEEEEECCCCHHHH		14.5520377248
1003PhosphorylationEVIMHSPSDPEYALK
EEEEECCCCHHHHCC		69.6619779198
1007PhosphorylationHSPSDPEYALKSQTL
ECCCCHHHHCCCHHC		23.7124961812
1011PhosphorylationDPEYALKSQTLRSSS
CHHHHCCCHHCCCCC		29.2819823750
1013PhosphorylationEYALKSQTLRSSSQT
HHHCCCHHCCCCCCC		31.0921440633
1016PhosphorylationLKSQTLRSSSQTVIN
CCCHHCCCCCCCEEC		37.1422369663
1017PhosphorylationKSQTLRSSSQTVINS
CCHHCCCCCCCEECC		21.7420377248
1018PhosphorylationSQTLRSSSQTVINSK
CHHCCCCCCCEECCC		30.9922369663
1020PhosphorylationTLRSSSQTVINSKRP
HCCCCCCCEECCCCC		25.8722369663
1024PhosphorylationSSQTVINSKRPVKIE
CCCCEECCCCCCCCC		20.9319823750
1057PhosphorylationQAPPRAPSTLSYNHS
CCCCCCCCCCCCCCC		40.7825005228
1060PhosphorylationPRAPSTLSYNHSKNN
CCCCCCCCCCCCCCC		24.7928889911
1090PhosphorylationNRKKKRGSFARHRTI
CHHCCCCCCCCCCCC		21.5525533186
1125PhosphorylationAANILGASAEDNTHP
HHHHHCCCCCCCCCC		30.3228889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NAB6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NAB6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NAB6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PABP_YEASTPAB1physical
16429126
SUB1_YEASTSUB1genetic
22575652
PAP_YEASTPAP1genetic
27845367
CBF3B_YEASTCEP3genetic
27708008
TYSY_YEASTCDC21genetic
27708008
THRC_YEASTTHR4genetic
27708008
ERD2_YEASTERD2genetic
27708008
AAR2_YEASTAAR2genetic
27708008
KPC1_YEASTPKC1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
GPI8_YEASTGPI8genetic
27708008
RMRP_YEASTSNM1genetic
27708008
GNA1_YEASTGNA1genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
COPB2_YEASTSEC27genetic
27708008
CDC12_YEASTCDC12genetic
27708008
GPI16_YEASTGPI16genetic
27708008
ARPC5_YEASTARC15genetic
27708008
GRP78_YEASTKAR2genetic
27708008
RFC2_YEASTRFC2genetic
27708008
TIM14_YEASTPAM18genetic
27708008
RU1C_YEASTYHC1genetic
27708008
SEN1_YEASTSEN1genetic
27708008
CDC91_YEASTGAB1genetic
27708008
ROT1_YEASTROT1genetic
27708008
RNT1_YEASTRNT1genetic
27708008
CAP_YEASTSRV2genetic
27708008
APC5_YEASTAPC5genetic
27708008
CLP1_YEASTCLP1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
GPI2_YEASTGPI2genetic
27708008
ATC3_YEASTDRS2genetic
27708008
BUD31_YEASTBUD31genetic
27708008
MTU1_YEASTSLM3genetic
27708008
GPR1_YEASTGPR1genetic
27708008
OST4_YEASTOST4genetic
27708008
YD090_YEASTYDR090Cgenetic
27708008
SMI1_YEASTSMI1genetic
27708008
NVJ1_YEASTNVJ1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
BCK1_YEASTBCK1genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
ILM1_YEASTILM1genetic
27708008
PGM1_YEASTPGM1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
FKS1_YEASTFKS1genetic
27708008
GAS1_YEASTGAS1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
INO4_YEASTINO4genetic
27708008
DIA2_YEASTDIA2genetic
27708008
YP066_YEASTRGL1genetic
27708008
SRO7_YEASTSRO7genetic
27708008
CGS5_YEASTCLB5genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NAB6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445; SER-448; SER-449;SER-467; SER-497; SER-614; SER-993; SER-1018 AND SER-1125, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464 AND SER-993, ANDMASS SPECTROMETRY.

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