YD090_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YD090_YEAST
• UniProt AC: Q03193
• Protein Name: Uncharacterized membrane protein YDR090C
• Gene Name: YDR090C
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 310
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Sequence: MISEKAATALATIATVCWCVQLIPQIIYNWKKKDCTGLPPLMMFLWVVSGIPFAIYFCVSKGNVILQVQPHLFMFFCSISFVQSCYYPPISMARSKIVMIVAAIIAADVGMEVGFILWLRPLYEKGVKWPDLIFGISASVLLAVGLLPPYFELAKRKGRVIGINFAFLFIDSLGAWLSIISVILGNMDIMGIILYSIVAGMELGIFASHFIWWCRFRFLAKGNTFDEESGQAQKEEPDEKIEQDISKSDRNVTNYNLDNCSIPDDASSFADDFNIYDSTDGGTLSRAQTLHAVHGVVVRTDPDRYSRLSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
224	Phosphorylation	RFLAKGNTFDEESGQ HHHHCCCCCCCCCCC	40.92	20377248
229	Phosphorylation	GNTFDEESGQAQKEE CCCCCCCCCCCCHHC	33.87	22369663
234	Ubiquitination	EESGQAQKEEPDEKI CCCCCCCHHCCCHHH	68.04	23749301
240	Ubiquitination	QKEEPDEKIEQDISK CHHCCCHHHHHHCCH	59.95	23749301
246	Phosphorylation	EKIEQDISKSDRNVT HHHHHHCCHHHCCCC	34.10	28889911
247	Ubiquitination	KIEQDISKSDRNVTN HHHHHCCHHHCCCCC	57.62	23749301
248	Phosphorylation	IEQDISKSDRNVTNY HHHHCCHHHCCCCCC	34.70	28889911
251	N-linked_Glycosylation	DISKSDRNVTNYNLD HCCHHHCCCCCCCCC	50.37	-
259	N-linked_Glycosylation	VTNYNLDNCSIPDDA CCCCCCCCCCCCCCH	25.30	-
289	Phosphorylation	GTLSRAQTLHAVHGV CCCCHHHHHEEECEE	21.37	21440633
305	Phosphorylation	VRTDPDRYSRLSV-- EECCCCCCCCCCC--	12.91	27017623
306	Phosphorylation	RTDPDRYSRLSV--- ECCCCCCCCCCC---	27.86	28889911
309	Phosphorylation	PDRYSRLSV------ CCCCCCCCC------	25.35	21440633

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YD090_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YD090_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YD090_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC11_YEAST	APC11	genetic	27708008
CDC53_YEAST	CDC53	genetic	27708008
RPB1_YEAST	RPO21	genetic	27708008
TCPD_YEAST	CCT4	genetic	27708008
TFB1_YEAST	TFB1	genetic	27708008
RPB7_YEAST	RPB7	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
PRP43_YEAST	PRP43	genetic	27708008
RRP3_YEAST	RRP3	genetic	27708008
ARP4_YEAST	ARP4	genetic	27708008
KRE9_YEAST	KRE9	genetic	27708008
PRS7_YEAST	RPT1	genetic	27708008
MED14_YEAST	RGR1	genetic	27708008
DCP2_YEAST	DCP2	genetic	27708008
CAP_YEAST	SRV2	genetic	27708008
NUF2_YEAST	NUF2	genetic	27708008
PROF_YEAST	PFY1	genetic	27708008
RPB2_YEAST	RPB2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, AND MASSSPECTROMETRY.
PubMed: 17330950

"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309, AND MASSSPECTROMETRY.
PubMed: 11875433