PAP_YEAST - dbPTM
PAP_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PAP_YEAST
UniProt AC P29468
Protein Name Poly(A) polymerase
Gene Name PAP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 568
Subcellular Localization Nucleus .
Protein Description Polymerase component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB..
Protein Sequence MSSQKVFGITGPVSTVGATAAENKLNDSLIQELKKEGSFETEQETANRVQVLKILQELAQRFVYEVSKKKNMSDGMARDAGGKIFTYGSYRLGVHGPGSDIDTLVVVPKHVTREDFFTVFDSLLRERKELDEIAPVPDAFVPIIKIKFSGISIDLICARLDQPQVPLSLTLSDKNLLRNLDEKDLRALNGTRVTDEILELVPKPNVFRIALRAIKLWAQRRAVYANIFGFPGGVAWAMLVARICQLYPNACSAVILNRFFIILSEWNWPQPVILKPIEDGPLQVRVWNPKIYAQDRSHRMPVITPAYPSMCATHNITESTKKVILQEFVRGVQITNDIFSNKKSWANLFEKNDFFFRYKFYLEITAYTRGSDEQHLKWSGLVESKVRLLVMKLEVLAGIKIAHPFTKPFESSYCCPTEDDYEMIQDKYGSHKTETALNALKLVTDENKEEESIKDAPKAYLSTMYIGLDFNIENKKEKVDIHIPCTEFVNLCRSFNEDYGDHKVFNLALRFVKGYDLPDEVFDENEKRPSKKSKRKNLDARHETVKRSKSDAASGDNINGTTAAVDVN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationGITGPVSTVGATAAE
EECCCCCHHCHHHHH		24.1628889911
19PhosphorylationPVSTVGATAAENKLN
CCCHHCHHHHHHHCC		22.0728889911
28PhosphorylationAENKLNDSLIQELKK
HHHHCCHHHHHHHHH		26.7130377154
38PhosphorylationQELKKEGSFETEQET
HHHHHCCCCCCHHHH		22.4730377154
444PhosphorylationLNALKLVTDENKEEE
HHHHHHHCCCCCCHH		48.2930377154
448AcetylationKLVTDENKEEESIKD
HHHCCCCCCHHCHHH		65.5424489116
452PhosphorylationDENKEEESIKDAPKA
CCCCCHHCHHHHCHH		37.9120377248
503AcetylationNEDYGDHKVFNLALR
CCCCCCCHHHHHHHH		53.9424489116
548PhosphorylationRHETVKRSKSDAASG
HHHHHHHHHHHHCCC		30.6928889911
550PhosphorylationETVKRSKSDAASGDN
HHHHHHHHHHCCCCC		33.4617850751
554PhosphorylationRSKSDAASGDNINGT
HHHHHHCCCCCCCCC		48.6924961812
561PhosphorylationSGDNINGTTAAVDVN
CCCCCCCCEEEEECC		14.5830377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PAP_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PAP_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PAP_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CFT1_YEASTCFT1physical
11805826
CFT2_YEASTCFT2physical
11805826
FIP1_YEASTFIP1physical
11805826
PP12_YEASTGLC7physical
11805826
PFS2_YEASTPFS2physical
11805826
PTA1_YEASTPTA1physical
11805826
RNA14_YEASTRNA14physical
11805826
SSU72_YEASTSSU72physical
11805826
VPS53_YEASTVPS53physical
11805826
PTI1_YEASTPTI1physical
11805826
MPE1_YEASTMPE1physical
11805826
YSH1_YEASTYSH1physical
11805826
YTH1_YEASTYTH1physical
11805826
CFT1_YEASTCFT1physical
10523662
FIP1_YEASTFIP1physical
10523662
PHO85_YEASTPHO85physical
12174300
YSH1_YEASTYSH1physical
10523662
CFT2_YEASTCFT2physical
10523662
PTA1_YEASTPTA1physical
10523662
PHO85_YEASTPHO85physical
12174291
UBA2_YEASTUBA2physical
9236779
UFD1_YEASTUFD1physical
9236779
FIP1_YEASTFIP1physical
11238938
RNA14_YEASTRNA14genetic
7992054
RNA15_YEASTRNA15genetic
7992054
RPC2_YEASTRET1genetic
8807289
RRP6_YEASTRRP6genetic
10611239
LCP5_YEASTLCP5genetic
9814757
FIP1_YEASTFIP1physical
16554755
FIP1_YEASTFIP1physical
16429126
RNA14_YEASTRNA14physical
16429126
CFT1_YEASTCFT1physical
16429126
CFT2_YEASTCFT2physical
16429126
MPE1_YEASTMPE1physical
16429126
PFS2_YEASTPFS2physical
16429126
PTA1_YEASTPTA1physical
16429126
PTI1_YEASTPTI1physical
16429126
RL8A_YEASTRPL8Aphysical
16429126
SSU72_YEASTSSU72physical
16429126
SWD2_YEASTSWD2physical
16429126
YSH1_YEASTYSH1physical
16429126
YTH1_YEASTYTH1physical
16429126
PP12_YEASTGLC7physical
16429126
PAP2_YEASTPAP2genetic
18007593
SSB1_YEASTSSB1physical
19536198
RRP6_YEASTRRP6genetic
11586364
SUB1_YEASTSUB1physical
22575652
NAB6_YEASTNAB6physical
22575652
FIP1_YEASTFIP1physical
22575652
RRP6_YEASTRRP6genetic
23770821
FIP1_YEASTFIP1physical
9236779
CND2_YEASTBRN1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
SLU7_YEASTSLU7genetic
27708008
PCF11_YEASTPCF11genetic
27708008
NSE3_YEASTNSE3genetic
27708008
RMRP_YEASTSNM1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
ERG26_YEASTERG26genetic
27708008
RNA15_YEASTRNA15genetic
27708008
SLD3_YEASTSLD3genetic
27708008
BRR6_YEASTBRR6genetic
27708008
ESP1_YEASTESP1genetic
27708008
BRL1_YEASTBRL1genetic
27708008
MED6_YEASTMED6genetic
27708008
PRI1_YEASTPRI1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
FIP1_YEASTFIP1genetic
27708008
RRN3_YEASTRRN3genetic
27708008
RU1C_YEASTYHC1genetic
27708008
VTI1_YEASTVTI1genetic
27708008
SGT1_YEASTSGT1genetic
27708008
PROF_YEASTPFY1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
TFC8_YEASTTFC8genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PAP_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452 AND SER-548, ANDMASS SPECTROMETRY.

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