LCP5_YEAST - dbPTM
LCP5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LCP5_YEAST
UniProt AC P40079
Protein Name U3 small nucleolar ribonucleoprotein protein LCP5
Gene Name LCP5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 357
Subcellular Localization Nucleus, nucleolus.
Protein Description Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 of the pre-ribosomal RNA. Participates in ribosome biogenesis..
Protein Sequence MSELNALLKDINGSLTATSESLERLSGIYSNSATDEIPESNQLHEHLFYDAKKPAEKVSLLSLKNGSMLGYINSLLMLIGNRLDDECKDPSAMDARERSIQHRVVLERGVKPLEKKLAYQLDKLTRAYVKMEKEYKDAEKRALEKSTLVNHSGNDDSEDDESSEDEIAYRPNTSGIINTNKKSSAYRVEETAKQENGEENDDNETGVYKPPKITAVLPPQQTHFEDRFDAREHKDRSNKSRMQAMEEYIRESSDQPDWSASIGADIVNHGRGGIKSLRDTEKERRVTSFEEDNFTRLNITNKAEKRKQKQRERNARMNVIGGEDFGIFSSKRKLEDSTSRRGAKKTRSAWDRAQRRL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSELNALLK
------CHHHHHHHH		51.2822814378
2Phosphorylation------MSELNALLK
------CHHHHHHHH		51.2829136822
14PhosphorylationLLKDINGSLTATSES
HHHHHCCCCEECHHH		20.3329136822
16PhosphorylationKDINGSLTATSESLE
HHHCCCCEECHHHHH		29.5929136822
18PhosphorylationINGSLTATSESLERL
HCCCCEECHHHHHHH		28.0029136822
19PhosphorylationNGSLTATSESLERLS
CCCCEECHHHHHHHH		23.7929136822
21PhosphorylationSLTATSESLERLSGI
CCEECHHHHHHHHCC		34.9829136822
123AcetylationKLAYQLDKLTRAYVK
HHHHHHHHHHHHHHH		61.4224489116
146PhosphorylationEKRALEKSTLVNHSG
HHHHHHHHCCCCCCC		20.0021440633
147PhosphorylationKRALEKSTLVNHSGN
HHHHHHHCCCCCCCC		45.8821440633
152PhosphorylationKSTLVNHSGNDDSED
HHCCCCCCCCCCCCC		33.8022890988
157PhosphorylationNHSGNDDSEDDESSE
CCCCCCCCCCCCCCH		45.8722890988
162PhosphorylationDDSEDDESSEDEIAY
CCCCCCCCCHHHHCC		46.1222890988
163PhosphorylationDSEDDESSEDEIAYR
CCCCCCCCHHHHCCC		47.2022890988
169PhosphorylationSSEDEIAYRPNTSGI
CCHHHHCCCCCCCCC		32.0619795423
173PhosphorylationEIAYRPNTSGIINTN
HHCCCCCCCCCCCCC		30.8919795423
174PhosphorylationIAYRPNTSGIINTNK
HCCCCCCCCCCCCCC		34.3419795423
179PhosphorylationNTSGIINTNKKSSAY
CCCCCCCCCCCCCCE		37.7019795423
191PhosphorylationSAYRVEETAKQENGE
CCEEHHHHHHHHCCC		26.1625704821
252PhosphorylationMEEYIRESSDQPDWS
HHHHHHHCCCCCCCC		29.3930377154
253PhosphorylationEEYIRESSDQPDWSA
HHHHHHCCCCCCCCH		35.2030377154
275AcetylationNHGRGGIKSLRDTEK
CCCCCCCHHHCCCHH		46.8725381059
276PhosphorylationHGRGGIKSLRDTEKE
CCCCCCHHHCCCHHH		27.0730377154
287PhosphorylationTEKERRVTSFEEDNF
CHHHHCCCCCCCCCC		26.3623749301
288PhosphorylationEKERRVTSFEEDNFT
HHHHCCCCCCCCCCH		28.0125533186
329PhosphorylationGEDFGIFSSKRKLED
CCCCCCCCCCCCCCC		32.7930377154
331AcetylationDFGIFSSKRKLEDST
CCCCCCCCCCCCCCC		52.9725381059
333AcetylationGIFSSKRKLEDSTSR
CCCCCCCCCCCCCCH		61.0225381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LCP5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LCP5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LCP5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BFR2_YEASTBFR2physical
10688190
RCL1_YEASTRCL1physical
10790377
FAL1_YEASTFAL1genetic
9814757
BFR2_YEASTBFR2physical
11283351
ATG17_YEASTATG17physical
11283351
RIC1_YEASTRIC1genetic
19061648
SLS1_YEASTSLS1genetic
19061648
NMD4_YEASTNMD4genetic
19061648
DBP3_YEASTDBP3genetic
19061648
UPF3_YEASTUPF3genetic
19061648
IF4A_YEASTTIF2genetic
19061648
MRT4_YEASTMRT4genetic
19061648
SRP40_YEASTSRP40genetic
19061648
NOP12_YEASTNOP12genetic
19061648
RRP6_YEASTRRP6genetic
19061648
BUD21_YEASTBUD21genetic
19061648
EFTU_YEASTTUF1genetic
19061648
NAM7_YEASTNAM7genetic
19061648
SYDM_YEASTMSD1genetic
19061648
SSF1_YEASTSSF1genetic
19061648
NMD2_YEASTNMD2genetic
19061648
LRP1_YEASTLRP1genetic
19061648
PRP18_YEASTPRP18genetic
27708008
CDC11_YEASTCDC11genetic
27708008
RL4A_YEASTRPL4Agenetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
SDS3_YEASTSDS3genetic
27708008
YO014_YEASTYOL014Wgenetic
27708008
HAT1_YEASTHAT1genetic
27708008
CTI6_YEASTCTI6genetic
27708008
DEP1_YEASTDEP1genetic
27708008
TFS2_YEASTDST1genetic
27708008
APC11_YEASTAPC11genetic
27708008
NOP14_YEASTNOP14genetic
27708008
NHP2_YEASTNHP2genetic
27708008
FAL1_YEASTFAL1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
UTP5_YEASTUTP5genetic
27708008
UTP6_YEASTUTP6genetic
27708008
RMRP_YEASTSNM1genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
BCD1_YEASTBCD1genetic
27708008
UTP9_YEASTUTP9genetic
27708008
NUP85_YEASTNUP85genetic
27708008
DCA13_YEASTSOF1genetic
27708008
NEP1_YEASTEMG1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
UTP13_YEASTUTP13genetic
27708008
SEC22_YEASTSEC22genetic
27708008
IMB1_YEASTKAP95genetic
27708008
UTP15_YEASTUTP15genetic
27708008
RRP5_YEASTRRP5genetic
27708008
SMP3_YEASTSMP3genetic
27708008
IPL1_YEASTIPL1genetic
27708008
TF2B_YEASTSUA7genetic
27708008
PSB5_YEASTPRE2genetic
27708008
CDC15_YEASTCDC15genetic
27708008
PRP6_YEASTPRP6genetic
27708008
NU145_YEASTNUP145genetic
27708008
KRE9_YEASTKRE9genetic
27708008
FIP1_YEASTFIP1genetic
27708008
NAT10_YEASTKRE33genetic
27708008
DED1_YEASTDED1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
H3_YEASTHHT1genetic
27708008
GBP2_YEASTGBP2genetic
27708008
PAT1_YEASTPAT1genetic
27708008
PDP2_YEASTPTC6genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
MDHP_YEASTMDH3genetic
27708008
PCL2_YEASTPCL2genetic
27708008
VPS41_YEASTVPS41genetic
27708008
SAC3_YEASTSAC3genetic
27708008
LIC4_YEASTATC1genetic
27708008
RIM15_YEASTRIM15genetic
27708008
UBP6_YEASTUBP6genetic
27708008
PUF4_YEASTPUF4genetic
27708008
GCN1_YEASTGCN1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
MAL12_YEASTMAL12genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
BFA1_YEASTBFA1genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
DOM34_YEASTDOM34genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
BUD21_YEASTBUD21genetic
27708008
SUR1_YEASTSUR1genetic
27708008
YP109_YEASTYPL109Cgenetic
27708008
HIR1_YEASTHIR1genetic
27708008
TPS1_YEASTTPS1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
ATG9_YEASTATG9genetic
27708008
MNN10_YEASTMNN10genetic
27708008
MST27_YEASTMST27genetic
27708008
ACOX_YEASTPOX1genetic
27708008
RTG2_YEASTRTG2genetic
27708008
DSE2_YEASTDSE2genetic
27708008
CSK21_YEASTCKA1genetic
27708008
LSM1_YEASTLSM1genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
VPS24_YEASTVPS24genetic
27708008
ELM1_YEASTELM1genetic
27708008
FEN1_YEASTRAD27genetic
27708008
RL1D1_YEASTUTP30genetic
27708008
SIS2_YEASTSIS2genetic
27708008
HBS1_YEASTHBS1genetic
27708008
SRP40_YEASTSRP40genetic
27708008
POM33_YEASTPOM33genetic
27708008
FPS1_YEASTFPS1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
SEI1_YEASTFLD1genetic
27708008
VIP1_YEASTVIP1genetic
27708008
YPT7_YEASTYPT7genetic
27708008
CSI1_YEASTCSI1genetic
27708008
TRI1_YEASTTRI1genetic
27708008
PMS1_YEASTPMS1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
MSH2_YEASTMSH2genetic
27708008
INO4_YEASTINO4genetic
27708008
WHI5_YEASTWHI5genetic
27708008
HAP5_YEASTHAP5genetic
27708008
RAD1_YEASTRAD1genetic
27708008
MET31_YEASTMET31genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LCP5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-288, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, AND MASSSPECTROMETRY.

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