dbPTM

RCL1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RCL1_YEAST
UniProt AC	Q08096
Protein Name	RNA 3'-terminal phosphate cyclase-like protein
Gene Name	RCL1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	367
Subcellular Localization	Nucleus, nucleolus.
Protein Description	Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA. Essential for viability..
Protein Sequence	MSSSAPKYTTFQGSQNFRLRIVLATLSGKPIKIEKIRSGDLNPGLKDYEVSFLRLIESVTNGSVIEISYTGTTVIYRPGIIVGGASTHICPSSKPVGYFVEPMLYLAPFSKKKFSILFKGITASHNDAGIEAIKWGLMPVMEKFGVRECALHTLKRGSPPLGGGEVHLVVDSLIAQPITMHEIDRPIISSITGVAYSTRVSPSLVNRMIDGAKKVLKNLQCEVNITADVWRGENSGKSPGWGITLVAQSKQKGWSYFAEDIGDAGSIPEELGEKVACQLLEEISKSAAVGRNQLPLAIVYMVIGKEDIGRLRINKEQIDERFIILLRDIKKIFNTEVFLKPVDEADNEDMIATIKGIGFTNTSKKIA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSSAPKYT ------CCCCCCCCC	32.76	22814378
8	Phosphorylation	MSSSAPKYTTFQGSQ CCCCCCCCCCCCCCC	15.23	28132839
9	Phosphorylation	SSSAPKYTTFQGSQN CCCCCCCCCCCCCCC	27.53	19779198
10	Phosphorylation	SSAPKYTTFQGSQNF CCCCCCCCCCCCCCE	15.75	19779198
46	Acetylation	GDLNPGLKDYEVSFL CCCCCCCCCCEEEHH	65.27	24489116
266	Phosphorylation	EDIGDAGSIPEELGE HHHCCCCCCCHHHHH	36.37	21440633

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RCL1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RCL1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RCL1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BMS1_YEAST	BMS1	physical	14759368
RCL1_YEAST	RCL1	physical	14759368
BMS1_YEAST	BMS1	physical	12150911
DHR1_YEAST	ECM16	physical	12150911
NOP14_YEAST	NOP14	physical	12150911
RCL1_YEAST	RCL1	physical	12150911
UTP20_YEAST	UTP20	physical	12150911
UTP10_YEAST	UTP10	physical	12150911
RNT1_YEAST	RNT1	physical	16554755
BMS1_YEAST	BMS1	physical	16554755
BMS1_YEAST	BMS1	physical	16429126
DHR1_YEAST	ECM16	physical	16429126
NOP14_YEAST	NOP14	physical	16429126
RS11A_YEAST	RPS11A	physical	16429126
RS11B_YEAST	RPS11A	physical	16429126
RS4A_YEAST	RPS4A	physical	16429126
RS4B_YEAST	RPS4A	physical	16429126
UTP10_YEAST	UTP10	physical	16429126
UTP20_YEAST	UTP20	physical	16429126
RS8A_YEAST	RPS8A	physical	16429126
RS8B_YEAST	RPS8A	physical	16429126
BMS1_YEAST	BMS1	physical	16376378
SSB1_YEAST	SSB1	physical	19536198
BMS1_YEAST	BMS1	physical	25064857
NOP2_YEAST	NOP2	genetic	27708008
RS10A_YEAST	RPS10A	genetic	27708008
NOP14_YEAST	NOP14	genetic	27708008
TIM22_YEAST	TIM22	genetic	27708008
UTP6_YEAST	UTP6	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
PALF_YEAST	RIM8	genetic	27708008
YM71_YEAST	YMR226C	genetic	27708008
YP216_YEAST	YPL216W	genetic	27708008
YP229_YEAST	YPL229W	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RCL1_YEAST

Related Literatures of Post-Translational Modification