YM71_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YM71_YEAST
• UniProt AC: Q05016
• Protein Name: NADP-dependent 3-hydroxy acid dehydrogenase {ECO:0000303|PubMed:12535615}
• Gene Name: YMR226C {ECO:0000312|SGD:S000004839}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 267
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate..
• Protein Sequence: MSQGRKAAERLAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHVAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTALINITQAVLPIFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELINTKIRVILIAPGLVETEFSLVRYRGNEEQAKNVYKDTTPLMADDVADLIVYATSRKQNTVIADTLIFPTNQASPHHIFRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	AERLAKKTVLITGAS HHHHHHCEEEEEECC	21.60	22369663
19	Phosphorylation	AKKTVLITGASAGIG HHCEEEEEECCCCCC	23.64	22369663
22	Phosphorylation	TVLITGASAGIGKAT EEEEEECCCCCCHHH	28.51	22369663
52	Acetylation	LAARRLEKLEELKKT HHHHHHHHHHHHHHH	66.83	24489116
58	Ubiquitination	EKLEELKKTIDQEFP HHHHHHHHHHCHHCC	64.44	23749301
58	Acetylation	EKLEELKKTIDQEFP HHHHHHHHHHCHHCC	64.44	24489116
172	Acetylation	GSIYCASKFAVGAFT CCEEEEHHHHHCCCC	20.86	25381059
184	Ubiquitination	AFTDSLRKELINTKI CCCHHHHHHHHHCCE	63.26	23749301
190	Ubiquitination	RKELINTKIRVILIA HHHHHHCCEEEEEEC	24.83	23749301
218	Acetylation	RGNEEQAKNVYKDTT CCCHHHHHHHCCCCC	46.79	25381059
246	Phosphorylation	ATSRKQNTVIADTLI HHCCCCCEEEEEEEE	15.70	22369663
251	Phosphorylation	QNTVIADTLIFPTNQ CCEEEEEEEEEECCC	16.84	22369663
256	Phosphorylation	ADTLIFPTNQASPHH EEEEEEECCCCCCCC	29.25	22369663
260	Phosphorylation	IFPTNQASPHHIFRG EEECCCCCCCCCCCC	18.27	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YM71_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YM71_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YM71_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THRC_YEAST	THR4	genetic	21623372
6P22_YEAST	PFK27	genetic	21623372
EPT1_YEAST	EPT1	genetic	21623372
F26_YEAST	FBP26	genetic	21623372
INO1_YEAST	INO1	genetic	21623372
AATC_YEAST	AAT2	genetic	21623372
PHO84_YEAST	PHO84	genetic	21623372
G3P2_YEAST	TDH2	genetic	21623372
LTHAD_YEAST	SRY1	genetic	21623372
ACS1_YEAST	ACS1	genetic	21623372
MET8_YEAST	MET8	genetic	21623372
SEC7_YEAST	SEC7	genetic	27708008
SHG1_YEAST	SHG1	genetic	27708008
RAD1_YEAST	RAD1	genetic	27708008
CDC48_YEAST	CDC48	genetic	27708008
FAL1_YEAST	FAL1	genetic	27708008
RTG3_YEAST	RTG3	genetic	27708008
STE50_YEAST	STE50	genetic	27708008
RIM1_YEAST	RIM1	genetic	27708008
RM01_YEAST	MRPL1	genetic	27708008
DOT1_YEAST	DOT1	genetic	27708008
DLDH_YEAST	LPD1	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
ILM1_YEAST	ILM1	genetic	27708008
COA4_YEAST	COA4	genetic	27708008
SWS2_YEAST	SWS2	genetic	27708008
MKT1_YEAST	MKT1	genetic	27708008
YP109_YEAST	YPL109C	genetic	27708008
NEW1_YEAST	NEW1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.