G3P2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: G3P2_YEAST
• UniProt AC: P00358
• Protein Name: Glyceraldehyde-3-phosphate dehydrogenase 2
• Gene Name: TDH2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 332
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MVRVAINGFGRIGRLVMRIALQRKNVEVVALNDPFISNDYSAYMFKYDSTHGRYAGEVSHDDKHIIVDGHKIATFQERDPANLPWASLNIDIAIDSTGVFKELDTAQKHIDAGAKKVVITAPSSTAPMFVMGVNEEKYTSDLKIVSNASCTTNCLAPLAKVINDAFGIEEGLMTTVHSMTATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVLPELQGKLTGMAFRVPTVDVSVVDLTVKLNKETTYDEIKKVVKAAAEGKLKGVLGYTEDAVVSSDFLGDSNSSIFDAAAGIQLSPKFVKLVSWYDNEYGYSTRVVDLVEHVAKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Acetylation	MRIALQRKNVEVVAL HHHHHHCCCEEEEEE	53.00	24489116
24	Ubiquitination	MRIALQRKNVEVVAL HHHHHHCCCEEEEEE	53.00	23749301
46	Acetylation	DYSAYMFKYDSTHGR CCEEEEEEEECCCCE	31.45	24489116
46	Succinylation	DYSAYMFKYDSTHGR CCEEEEEEEECCCCE	31.45	23954790
46	Ubiquitination	DYSAYMFKYDSTHGR CCEEEEEEEECCCCE	31.45	23749301
47	Phosphorylation	YSAYMFKYDSTHGRY CEEEEEEEECCCCEE	12.12	21440633
49	Phosphorylation	AYMFKYDSTHGRYAG EEEEEEECCCCEECE	21.15	17287358
50	Phosphorylation	YMFKYDSTHGRYAGE EEEEEECCCCEECEE	26.00	17287358
54	Phosphorylation	YDSTHGRYAGEVSHD EECCCCEECEEECCC	24.45	17287358
59	Phosphorylation	GRYAGEVSHDDKHII CEECEEECCCCCEEE	19.52	17287358
63	2-Hydroxyisobutyrylation	GEVSHDDKHIIVDGH EEECCCCCEEEECCE	42.64	-
63	Acetylation	GEVSHDDKHIIVDGH EEECCCCCEEEECCE	42.64	24489116
63	Ubiquitination	GEVSHDDKHIIVDGH EEECCCCCEEEECCE	42.64	23749301
71	2-Hydroxyisobutyrylation	HIIVDGHKIATFQER EEEECCEEEEEECCC	39.30	-
71	Acetylation	HIIVDGHKIATFQER EEEECCEEEEEECCC	39.30	24489116
71	Ubiquitination	HIIVDGHKIATFQER EEEECCEEEEEECCC	39.30	24961812
101	Acetylation	IDSTGVFKELDTAQK ECCCCHHHCHHHHHH	55.77	24489116
101	Succinylation	IDSTGVFKELDTAQK ECCCCHHHCHHHHHH	55.77	23954790
108	2-Hydroxyisobutyrylation	KELDTAQKHIDAGAK HCHHHHHHHHHCCCC	39.81	-
108	Acetylation	KELDTAQKHIDAGAK HCHHHHHHHHHCCCC	39.81	24489116
108	Succinylation	KELDTAQKHIDAGAK HCHHHHHHHHHCCCC	39.81	23954790
108	Ubiquitination	KELDTAQKHIDAGAK HCHHHHHHHHHCCCC	39.81	23749301
115	2-Hydroxyisobutyrylation	KHIDAGAKKVVITAP HHHHCCCCEEEEECC	45.22	-
115	Acetylation	KHIDAGAKKVVITAP HHHHCCCCEEEEECC	45.22	24489116
115	Succinylation	KHIDAGAKKVVITAP HHHHCCCCEEEEECC	45.22	23954790
115	Ubiquitination	KHIDAGAKKVVITAP HHHHCCCCEEEEECC	45.22	22817900
116	2-Hydroxyisobutyrylation	HIDAGAKKVVITAPS HHHCCCCEEEEECCC	41.00	-
116	Acetylation	HIDAGAKKVVITAPS HHHCCCCEEEEECCC	41.00	17397211
116	Ubiquitination	HIDAGAKKVVITAPS HHHCCCCEEEEECCC	41.00	23749301
120	Phosphorylation	GAKKVVITAPSSTAP CCCEEEEECCCCCCC	22.39	22369663
123	Phosphorylation	KVVITAPSSTAPMFV EEEEECCCCCCCEEE	37.55	22369663
124	Phosphorylation	VVITAPSSTAPMFVM EEEECCCCCCCEEEE	27.77	25521595
125	Phosphorylation	VITAPSSTAPMFVMG EEECCCCCCCEEEEE	38.83	25521595
137	Acetylation	VMGVNEEKYTSDLKI EEECCCHHCCCCCEE	47.88	24489116
137	Succinylation	VMGVNEEKYTSDLKI EEECCCHHCCCCCEE	47.88	23954790
137	Ubiquitination	VMGVNEEKYTSDLKI EEECCCHHCCCCCEE	47.88	23749301
138	Phosphorylation	MGVNEEKYTSDLKIV EECCCHHCCCCCEEE	18.11	27017623
139	Phosphorylation	GVNEEKYTSDLKIVS ECCCHHCCCCCEEEC	27.17	27017623
140	Phosphorylation	VNEEKYTSDLKIVSN CCCHHCCCCCEEECC	37.54	22369663
143	Acetylation	EKYTSDLKIVSNASC HHCCCCCEEECCCCC	46.16	24489116
143	Ubiquitination	EKYTSDLKIVSNASC HHCCCCCEEECCCCC	46.16	23749301
146	Phosphorylation	TSDLKIVSNASCTTN CCCCEEECCCCCCCC	30.10	25521595
149	Phosphorylation	LKIVSNASCTTNCLA CEEECCCCCCCCCHH	19.08	25521595
151	Phosphorylation	IVSNASCTTNCLAPL EECCCCCCCCCHHHH	20.67	25521595
152	Phosphorylation	VSNASCTTNCLAPLA ECCCCCCCCCHHHHH	28.41	25521595
160	Ubiquitination	NCLAPLAKVINDAFG CCHHHHHHHHHHHHC	51.86	17644757
174	Phosphorylation	GIEEGLMTTVHSMTA CCCCCCCCCHHEEEE	30.61	21440633
175	Phosphorylation	IEEGLMTTVHSMTAT CCCCCCCCHHEEEEE	11.40	22369663
178	Phosphorylation	GLMTTVHSMTATQKT CCCCCHHEEEEEECC	17.31	22369663
180	Phosphorylation	MTTVHSMTATQKTVD CCCHHEEEEEECCCC	29.57	22369663
182	Phosphorylation	TVHSMTATQKTVDGP CHHEEEEEECCCCCC	22.79	20377248
184	Acetylation	HSMTATQKTVDGPSH HEEEEEECCCCCCCC	46.27	24489116
184	Ubiquitination	HSMTATQKTVDGPSH HEEEEEECCCCCCCC	46.27	24961812
185	Phosphorylation	SMTATQKTVDGPSHK EEEEEECCCCCCCCC	17.63	29136822
190	Phosphorylation	QKTVDGPSHKDWRGG ECCCCCCCCCCCCCC	49.01	29136822
192	2-Hydroxyisobutyrylation	TVDGPSHKDWRGGRT CCCCCCCCCCCCCCC	64.42	-
192	Acetylation	TVDGPSHKDWRGGRT CCCCCCCCCCCCCCC	64.42	24489116
192	Malonylation	TVDGPSHKDWRGGRT CCCCCCCCCCCCCCC	64.42	27183143
192	Succinylation	TVDGPSHKDWRGGRT CCCCCCCCCCCCCCC	64.42	23954790
192	Ubiquitination	TVDGPSHKDWRGGRT CCCCCCCCCCCCCCC	64.42	23749301
199	Phosphorylation	KDWRGGRTASGNIIP CCCCCCCCCCCCCCC	28.57	22369663
201	Phosphorylation	WRGGRTASGNIIPSS CCCCCCCCCCCCCCC	31.59	22369663
207	Phosphorylation	ASGNIIPSSTGAAKA CCCCCCCCCHHHHHH	30.08	22369663
208	Phosphorylation	SGNIIPSSTGAAKAV CCCCCCCCHHHHHHH	26.04	22369663
209	Phosphorylation	GNIIPSSTGAAKAVG CCCCCCCHHHHHHHH	34.87	25521595
213	2-Hydroxyisobutyrylation	PSSTGAAKAVGKVLP CCCHHHHHHHHHHHH	42.97	-
213	Acetylation	PSSTGAAKAVGKVLP CCCHHHHHHHHHHHH	42.97	24489116
213	Succinylation	PSSTGAAKAVGKVLP CCCHHHHHHHHHHHH	42.97	23954790
213	Ubiquitination	PSSTGAAKAVGKVLP CCCHHHHHHHHHHHH	42.97	23749301
217	2-Hydroxyisobutyrylation	GAAKAVGKVLPELQG HHHHHHHHHHHHHHH	33.72	-
217	Acetylation	GAAKAVGKVLPELQG HHHHHHHHHHHHHHH	33.72	24489116
217	Succinylation	GAAKAVGKVLPELQG HHHHHHHHHHHHHHH	33.72	23954790
217	Ubiquitination	GAAKAVGKVLPELQG HHHHHHHHHHHHHHH	33.72	23749301
225	2-Hydroxyisobutyrylation	VLPELQGKLTGMAFR HHHHHHHHHCCEEEE	29.89	-
225	Acetylation	VLPELQGKLTGMAFR HHHHHHHHHCCEEEE	29.89	24489116
225	Succinylation	VLPELQGKLTGMAFR HHHHHHHHHCCEEEE	29.89	23954790
225	Ubiquitination	VLPELQGKLTGMAFR HHHHHHHHHCCEEEE	29.89	23749301
227	Phosphorylation	PELQGKLTGMAFRVP HHHHHHHCCEEEECC	28.53	22369663
235	Phosphorylation	GMAFRVPTVDVSVVD CEEEECCCCCEEEEE	26.87	22369663
239	Phosphorylation	RVPTVDVSVVDLTVK ECCCCCEEEEEEEEE	16.38	22369663
244	Phosphorylation	DVSVVDLTVKLNKET CEEEEEEEEECCCCC	15.90	21440633
246	2-Hydroxyisobutyrylation	SVVDLTVKLNKETTY EEEEEEEECCCCCCH	40.90	-
246	Acetylation	SVVDLTVKLNKETTY EEEEEEEECCCCCCH	40.90	24489116
246	Succinylation	SVVDLTVKLNKETTY EEEEEEEECCCCCCH	40.90	23954790
246	Ubiquitination	SVVDLTVKLNKETTY EEEEEEEECCCCCCH	40.90	23749301
249	2-Hydroxyisobutyrylation	DLTVKLNKETTYDEI EEEEECCCCCCHHHH	67.86	-
249	Acetylation	DLTVKLNKETTYDEI EEEEECCCCCCHHHH	67.86	24489116
249	Succinylation	DLTVKLNKETTYDEI EEEEECCCCCCHHHH	67.86	23954790
249	Ubiquitination	DLTVKLNKETTYDEI EEEEECCCCCCHHHH	67.86	23749301
251	Phosphorylation	TVKLNKETTYDEIKK EEECCCCCCHHHHHH	32.06	20377248
252	Phosphorylation	VKLNKETTYDEIKKV EECCCCCCHHHHHHH	30.02	22369663
253	Phosphorylation	KLNKETTYDEIKKVV ECCCCCCHHHHHHHH	20.99	22369663
257	2-Hydroxyisobutyrylation	ETTYDEIKKVVKAAA CCCHHHHHHHHHHHH	37.15	-
257	Acetylation	ETTYDEIKKVVKAAA CCCHHHHHHHHHHHH	37.15	24489116
257	Succinylation	ETTYDEIKKVVKAAA CCCHHHHHHHHHHHH	37.15	23954790
257	Ubiquitination	ETTYDEIKKVVKAAA CCCHHHHHHHHHHHH	37.15	23749301
258	Acetylation	TTYDEIKKVVKAAAE CCHHHHHHHHHHHHH	58.90	24489116
258	Succinylation	TTYDEIKKVVKAAAE CCHHHHHHHHHHHHH	58.90	23954790
258	Ubiquitination	TTYDEIKKVVKAAAE CCHHHHHHHHHHHHH	58.90	22817900
261	2-Hydroxyisobutyrylation	DEIKKVVKAAAEGKL HHHHHHHHHHHHCCC	34.98	-
261	Acetylation	DEIKKVVKAAAEGKL HHHHHHHHHHHHCCC	34.98	25381059
261	Succinylation	DEIKKVVKAAAEGKL HHHHHHHHHHHHCCC	34.98	23954790
261	Ubiquitination	DEIKKVVKAAAEGKL HHHHHHHHHHHHCCC	34.98	23749301
267	2-Hydroxyisobutyrylation	VKAAAEGKLKGVLGY HHHHHHCCCCEEECC	38.23	-
267	Acetylation	VKAAAEGKLKGVLGY HHHHHHCCCCEEECC	38.23	24489116
267	Succinylation	VKAAAEGKLKGVLGY HHHHHHCCCCEEECC	38.23	23954790
267	Ubiquitination	VKAAAEGKLKGVLGY HHHHHHCCCCEEECC	38.23	23749301
269	Ubiquitination	AAAEGKLKGVLGYTE HHHHCCCCEEECCCC	50.92	22817900
291	Phosphorylation	FLGDSNSSIFDAAAG CCCCCCCHHHHHHHC	31.37	28889911
302	Phosphorylation	AAAGIQLSPKFVKLV HHHCCCCCHHHHEEE	15.07	21440633
304	Ubiquitination	AGIQLSPKFVKLVSW HCCCCCHHHHEEEEE	60.45	22817900
307	Acetylation	QLSPKFVKLVSWYDN CCCHHHHEEEEECCC	46.43	24489116
307	Ubiquitination	QLSPKFVKLVSWYDN CCCHHHHEEEEECCC	46.43	23749301
310	Phosphorylation	PKFVKLVSWYDNEYG HHHHEEEEECCCCCC	30.29	17287358
312	Phosphorylation	FVKLVSWYDNEYGYS HHEEEEECCCCCCCC	11.03	28889911
319	Phosphorylation	YDNEYGYSTRVVDLV CCCCCCCCCCHHHHH	12.84	17287358
320	Phosphorylation	DNEYGYSTRVVDLVE CCCCCCCCCHHHHHH	20.99	17287358
331	2-Hydroxyisobutyrylation	DLVEHVAKA------ HHHHHHHHC------	54.24	-
331	Acetylation	DLVEHVAKA------ HHHHHHHHC------	54.24	24489116
331	Succinylation	DLVEHVAKA------ HHHHHHHHC------	54.24	23954790
331	Ubiquitination	DLVEHVAKA------ HHHHHHHHC------	54.24	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of G3P2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of G3P2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of G3P2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G3P3_YEAST	TDH3	genetic	2999100
G3P1_YEAST	TDH1	physical	16554755
GRP78_YEAST	KAR2	physical	16429126
HSP7F_YEAST	SSE1	physical	16429126
G3P3_YEAST	TDH3	genetic	18408719
G3P3_YEAST	TDH3	genetic	16941010
SIR2_YEAST	SIR2	genetic	19390637
HST2_YEAST	HST2	genetic	19390637
G3P3_YEAST	TDH3	genetic	20093466
DCOR_YEAST	SPE1	genetic	20093466
FPS1_YEAST	FPS1	genetic	20093466
ALAM_YEAST	ALT1	genetic	20093466
MSC1_YEAST	MSC1	genetic	20093466
RAS2_YEAST	RAS2	genetic	20093466
SUCA_YEAST	LSC1	genetic	20093466
SPEE_YEAST	SPE3	genetic	20093466
GPX3_YEAST	HYR1	physical	21229323
G3P3_YEAST	TDH3	genetic	19390637
G3P3_YEAST	TDH3	genetic	21623372
SPEE_YEAST	SPE3	genetic	21623372
DCAM_YEAST	SPE2	genetic	21623372
OSH7_YEAST	OSH7	genetic	23891562
TECR_YEAST	TSC13	genetic	23891562
TR130_YEAST	TRS130	genetic	23891562
ECM9_YEAST	ECM9	genetic	23891562
IMG2_YEAST	IMG2	genetic	27708008
RL19A_YEAST	RPL19B	genetic	27708008
RL19B_YEAST	RPL19B	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
VMS1_YEAST	VMS1	genetic	27708008
G3P3_YEAST	TDH3	genetic	27708008
ICE2_YEAST	ICE2	genetic	27708008
RL14A_YEAST	RPL14A	genetic	27708008
DCOR_YEAST	SPE1	genetic	27708008
FPS1_YEAST	FPS1	genetic	27708008
ALAM_YEAST	ALT1	genetic	27708008
TSR2_YEAST	TSR2	genetic	27708008
MSC1_YEAST	MSC1	genetic	27708008
RAS2_YEAST	RAS2	genetic	27708008
SPEE_YEAST	SPE3	genetic	27708008
PMP1_YEAST	PMP1	physical	26404137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; THR-50; TYR-54;SER-59; SER-310; SER-319 AND THR-320, AND MASS SPECTROMETRY.
PubMed: 17287358

"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149 AND SER-201, ANDMASS SPECTROMETRY.
PubMed: 15665377