GPX3_YEAST - dbPTM
GPX3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPX3_YEAST
UniProt AC P40581
Protein Name Glutathione peroxidase-like peroxiredoxin HYR1 {ECO:0000305}
Gene Name HYR1 {ECO:0000303|Ref.1}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 163
Subcellular Localization Cytoplasm . Mitochondrion intermembrane space . Peroxisome matrix .
Protein Description Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYR1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYR1/GPX3 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598'), which causes its nuclear accumulation and activation, and a reduced Cys-36 in HYR1/GPX3..
Protein Sequence MSEFYKLAPVDKKGQPFPFDQLKGKVVLIVNVASKCGFTPQYKELEALYKRYKDEGFTIIGFPCNQFGHQEPGSDEEIAQFCQLNYGVTFPIMKKIDVNGGNEDPVYKFLKSQKSGMLGLRGIKWNFEKFLVDKKGKVYERYSSLTKPSSLSETIEELLKEVE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Succinylation--MSEFYKLAPVDKK
--CCCCCCCCCCCCC		43.4223954790
23AcetylationPFPFDQLKGKVVLIV
CCCHHHCCCEEEEEE		51.5624489116
36S-nitrosylationIVNVASKCGFTPQYK
EEECHHHCCCCCCHH		5.1221844193
43AcetylationCGFTPQYKELEALYK
CCCCCCHHHHHHHHH		51.0424489116
50SuccinylationKELEALYKRYKDEGF
HHHHHHHHHHHCCCE		50.5323954790
50AcetylationKELEALYKRYKDEGF
HHHHHHHHHHHCCCE		50.5322865919
74PhosphorylationFGHQEPGSDEEIAQF
CCCCCCCCHHHHHHH		53.1927214570
108AcetylationGNEDPVYKFLKSQKS
CCCCHHHHHHHHCCC		44.4424489116
111UbiquitinationDPVYKFLKSQKSGML
CHHHHHHHHCCCCCC		54.7122817900
114UbiquitinationYKFLKSQKSGMLGLR
HHHHHHCCCCCCCCC		56.9423749301
115PhosphorylationKFLKSQKSGMLGLRG
HHHHHCCCCCCCCCC		23.0722369663
142PhosphorylationKGKVYERYSSLTKPS
CCCEEEEHHHCCCCC		7.2326447709
143PhosphorylationGKVYERYSSLTKPSS
CCEEEEHHHCCCCCC		25.7026447709
144PhosphorylationKVYERYSSLTKPSSL
CEEEEHHHCCCCCCH		30.9926447709
146PhosphorylationYERYSSLTKPSSLSE
EEEHHHCCCCCCHHH		42.7426447709
149PhosphorylationYSSLTKPSSLSETIE
HHHCCCCCCHHHHHH		45.5322369663
150PhosphorylationSSLTKPSSLSETIEE
HHCCCCCCHHHHHHH		44.4322369663
152PhosphorylationLTKPSSLSETIEELL
CCCCCCHHHHHHHHH		34.3422369663
154PhosphorylationKPSSLSETIEELLKE
CCCCHHHHHHHHHHH		30.2526447709
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GPX3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GPX3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPX3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GPX1_YEASTGPX1genetic
15337745
GPX2_YEASTGPX2genetic
15337745
MSRA_YEASTMXR1physical
16808898
AP1_YEASTYAP1physical
17720812
GPX3_YEASTHYR1physical
17720812
GLNA_YEASTGLN1physical
17707771
PEX11_YEASTPEX11physical
18467557
ALO_YEASTALO1physical
18467557
PUR92_YEASTADE17physical
18467557
PDR12_YEASTPDR12physical
18467557
TPO3_YEASTTPO3physical
18467557
YL345_YEASTYLR345Wphysical
18719252
GLRX2_YEASTGRX2physical
18756095
DAK1_YEASTDAK1physical
18756095
G3P2_YEASTTDH2physical
18756095
AP2_YEASTCAD1physical
18756095
T2EA_YEASTTFA1physical
18756095
MSRA_YEASTMXR1physical
18756095
PTR3_YEASTPTR3physical
18756095
YBP1_YEASTYBP1physical
18756095
PDI_YEASTPDI1physical
18756095
THI3_YEASTTHI3physical
18756095
GLNA_YEASTGLN1physical
18756095
AHP1_YEASTAHP1genetic
20145245
COQ4_YEASTCOQ4genetic
21623372
DHOM_YEASTHOM6genetic
21623372
CDC1_YEASTCDC1genetic
27708008
SNU56_YEASTSNU56genetic
27708008
TRS23_YEASTTRS23genetic
27708008
NSE3_YEASTNSE3genetic
27708008
TFB1_YEASTTFB1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
NEP1_YEASTEMG1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
RAD57_YEASTRAD57genetic
27708008
RAD55_YEASTRAD55genetic
27708008
XRS2_YEASTXRS2genetic
27708008
CTK1_YEASTCTK1genetic
27708008
TSA1_YEASTTSA1genetic
27708008
RAD52_YEASTRAD52genetic
27708008
MRE11_YEASTMRE11genetic
27708008
ISU1_YEASTISU1genetic
27708008
TM159_HUMANTMEM159physical
27107014
MIA40_YEASTMIA40physical
28297675
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPX3_YEAST

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Related Literatures of Post-Translational Modification

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