| UniProt ID | PDI_YEAST | |
|---|---|---|
| UniProt AC | P17967 | |
| Protein Name | Protein disulfide-isomerase | |
| Gene Name | PDI1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 522 | |
| Subcellular Localization | Endoplasmic reticulum lumen . | |
| Protein Description | Protein disulfide isomerase of ER lumen required for formation of disulfide bonds in secretory and cell-surface proteins and which unscrambles non-native disulfide bonds. Forms a complex with MNL1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response.. | |
| Protein Sequence | MKFSAGAVLSWSSLLLASSVFAQQEAVAPEDSAVVKLATDSFNEYIQSHDLVLAEFFAPWCGHCKNMAPEYVKAAETLVEKNITLAQIDCTENQDLCMEHNIPGFPSLKIFKNSDVNNSIDYEGPRTAEAIVQFMIKQSQPAVAVVADLPAYLANETFVTPVIVQSGKIDADFNATFYSMANKHFNDYDFVSAENADDDFKLSIYLPSAMDEPVVYNGKKADIADADVFEKWLQVEALPYFGEIDGSVFAQYVESGLPLGYLFYNDEEELEEYKPLFTELAKKNRGLMNFVSIDARKFGRHAGNLNMKEQFPLFAIHDMTEDLKYGLPQLSEEAFDELSDKIVLESKAIESLVKDFLKGDASPIVKSQEIFENQDSSVFQLVGKNHDEIVNDPKKDVLVLYYAPWCGHCKRLAPTYQELADTYANATSDVLIAKLDHTENDVRGVVIEGYPTIVLYPGGKKSESVVYQGSRSLDSLFDFIKENGHFDVDGKALYEEAQEKAAEEADADAELADEEDAIHDEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Ubiquitination | PEDSAVVKLATDSFN CCCCHHHHHHHHCHH | 26.30 | 17644757 | |
| 65 | Ubiquitination | APWCGHCKNMAPEYV HHHCHHCCCCCHHHH | 44.05 | 17644757 | |
| 82 | N-linked_Glycosylation | AETLVEKNITLAQID HHHHHHCCCEEEEEE | 20.97 | - | |
| 112 | Ubiquitination | FPSLKIFKNSDVNNS CCCCEEECCCCCCCC | 60.04 | 23749301 | |
| 117 | N-linked_Glycosylation | IFKNSDVNNSIDYEG EECCCCCCCCCCCCC | 41.33 | - | |
| 155 | N-linked_Glycosylation | DLPAYLANETFVTPV CHHHHHCCCCCCCEE | 46.36 | - | |
| 174 | N-linked_Glycosylation | GKIDADFNATFYSMA CCCCCCHHHHHHHHH | 38.32 | - | |
| 308 | Acetylation | HAGNLNMKEQFPLFA CCCCCCHHHHCCEEE | 47.49 | 24489116 | |
| 346 | Phosphorylation | SDKIVLESKAIESLV HHHHHHCHHHHHHHH | 24.19 | 19823750 | |
| 347 | Acetylation | DKIVLESKAIESLVK HHHHHCHHHHHHHHH | 43.97 | 24489116 | |
| 347 | Ubiquitination | DKIVLESKAIESLVK HHHHHCHHHHHHHHH | 43.97 | 17644757 | |
| 351 | Phosphorylation | LESKAIESLVKDFLK HCHHHHHHHHHHHHC | 32.14 | 19823750 | |
| 354 | Ubiquitination | KAIESLVKDFLKGDA HHHHHHHHHHHCCCC | 48.32 | 17644757 | |
| 354 | Acetylation | KAIESLVKDFLKGDA HHHHHHHHHHHCCCC | 48.32 | 24489116 | |
| 358 | Ubiquitination | SLVKDFLKGDASPIV HHHHHHHCCCCCCCC | 55.53 | 17644757 | |
| 358 | Acetylation | SLVKDFLKGDASPIV HHHHHHHCCCCCCCC | 55.53 | 24489116 | |
| 358 | Succinylation | SLVKDFLKGDASPIV HHHHHHHCCCCCCCC | 55.53 | 23954790 | |
| 362 | Phosphorylation | DFLKGDASPIVKSQE HHHCCCCCCCCCCHH | 21.65 | 23749301 | |
| 366 | Ubiquitination | GDASPIVKSQEIFEN CCCCCCCCCHHHHCC | 47.33 | 17644757 | |
| 367 | Phosphorylation | DASPIVKSQEIFENQ CCCCCCCCHHHHCCC | 23.35 | 28132839 | |
| 384 | Acetylation | SVFQLVGKNHDEIVN HHHHHHCCCHHHHCC | 43.56 | 24489116 | |
| 394 | Acetylation | DEIVNDPKKDVLVLY HHHCCCCCCCEEEEE | 65.55 | 22865919 | |
| 394 | Succinylation | DEIVNDPKKDVLVLY HHHCCCCCCCEEEEE | 65.55 | 23954790 | |
| 395 | Ubiquitination | EIVNDPKKDVLVLYY HHCCCCCCCEEEEEE | 59.46 | 17644757 | |
| 410 | Ubiquitination | APWCGHCKRLAPTYQ CCCCCHHHHHCHHHH | 44.78 | 17644757 | |
| 425 | N-linked_Glycosylation | ELADTYANATSDVLI HHHHHHCCCCCCEEE | 33.08 | - | |
| 460 | Acetylation | IVLYPGGKKSESVVY EEEECCCCCCCCEEE | 60.07 | 24489116 | |
| 462 | Phosphorylation | LYPGGKKSESVVYQG EECCCCCCCCEEECC | 38.29 | 21082442 | |
| 464 | Phosphorylation | PGGKKSESVVYQGSR CCCCCCCCEEECCCC | 24.79 | 23749301 | |
| 467 | Phosphorylation | KKSESVVYQGSRSLD CCCCCEEECCCCCHH | 12.66 | 28889911 | |
| 472 | Phosphorylation | VVYQGSRSLDSLFDF EEECCCCCHHHHHHH | 37.92 | 22369663 | |
| 475 | Phosphorylation | QGSRSLDSLFDFIKE CCCCCHHHHHHHHHH | 35.91 | 22369663 | |
| 491 | Acetylation | GHFDVDGKALYEEAQ CCCCCCHHHHHHHHH | 30.65 | 24489116 | |
| 500 | Ubiquitination | LYEEAQEKAAEEADA HHHHHHHHHHHHHHH | 40.59 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDI_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDI_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDI_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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