DIP5_YEAST - dbPTM
DIP5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DIP5_YEAST
UniProt AC P53388
Protein Name Dicarboxylic amino acid permease
Gene Name DIP5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 608
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Can transport glutamate, aspartate, glutamine, asparagine, serine, alanine and glycine..
Protein Sequence MKMPLKKMFTSTSPRNSSSLDSDHDAYYSKQNPDNFPVKEQEIYNIDLEENNVSSRSSTSTSPSARDDSFAVPDGKDENTRLRKDLKARHISMIAIGGSLGTGLLIGTGTALLTGGPVAMLIAYAFVGLLVFYTMACLGEMASYIPLDGFTSYASRYVDPALGFAIGYTYLFKYFILPPNQLTAAALVIQYWISRDRVNPGVWITIFLVVIVAINVVGVKFFGEFEFWLSSFKVMVMLGLILLLFIIMLGGGPNHDRLGFRYWRDPGAFKEYSTAITGGKGKFVSFVAVFVYSLFSYTGIELTGIVCSEAENPRKSVPKAIKLTVYRIIVFYLCTVFLLGMCVAYNDPRLLSTKGKSMSAAASPFVVAIQNSGIEVLPHIFNACVLVFVFSACNSDLYVSSRNLYALAIDGKAPKIFAKTSRWGVPYNALILSVLFCGLAYMNVSSGSAKIFNYFVNVVSMFGILSWITILIVYIYFDKACRAQGIDKSKFAYVAPGQRYGAYFALFFCILIALIKNFTVFLGHKFDYKTFITGYIGLPVYIISWAGYKLIYKTKVIKSTDVDLYTFKEIYDREEEEGRMKDQEKEERLKSNGKNMEWFYEKFLGNIF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Ubiquitination------MKMPLKKMF
------CCCCCHHCC		49.5822817900
6Ubiquitination--MKMPLKKMFTSTS
--CCCCCHHCCCCCC		36.0022817900
7Ubiquitination-MKMPLKKMFTSTSP
-CCCCCHHCCCCCCC		47.1023749301
10PhosphorylationMPLKKMFTSTSPRNS
CCCHHCCCCCCCCCC		27.8322369663
11PhosphorylationPLKKMFTSTSPRNSS
CCHHCCCCCCCCCCC		18.6720377248
12PhosphorylationLKKMFTSTSPRNSSS
CHHCCCCCCCCCCCC		39.4322369663
13PhosphorylationKKMFTSTSPRNSSSL
HHCCCCCCCCCCCCC		22.9422369663
17PhosphorylationTSTSPRNSSSLDSDH
CCCCCCCCCCCCCCH		23.6819823750
18PhosphorylationSTSPRNSSSLDSDHD
CCCCCCCCCCCCCHH		38.1719823750
19PhosphorylationTSPRNSSSLDSDHDA
CCCCCCCCCCCCHHH		35.7019823750
22PhosphorylationRNSSSLDSDHDAYYS
CCCCCCCCCHHHHHC		41.9819823750
27PhosphorylationLDSDHDAYYSKQNPD
CCCCHHHHHCCCCCC		17.8323749301
28PhosphorylationDSDHDAYYSKQNPDN
CCCHHHHHCCCCCCC		15.8821440633
29PhosphorylationSDHDAYYSKQNPDNF
CCHHHHHCCCCCCCC		18.3220377248
30UbiquitinationDHDAYYSKQNPDNFP
CHHHHHCCCCCCCCC		37.6623749301
39UbiquitinationNPDNFPVKEQEIYNI
CCCCCCCCHHEEEEE		54.6524961812
54PhosphorylationDLEENNVSSRSSTST
ECCCCCCCCCCCCCC		23.3528889911
55PhosphorylationLEENNVSSRSSTSTS
CCCCCCCCCCCCCCC		31.7229688323
57PhosphorylationENNVSSRSSTSTSPS
CCCCCCCCCCCCCCC		39.6619795423
58PhosphorylationNNVSSRSSTSTSPSA
CCCCCCCCCCCCCCC		25.8519795423
59PhosphorylationNVSSRSSTSTSPSAR
CCCCCCCCCCCCCCC		36.9519795423
60PhosphorylationVSSRSSTSTSPSARD
CCCCCCCCCCCCCCC		28.9219795423
61PhosphorylationSSRSSTSTSPSARDD
CCCCCCCCCCCCCCC		44.7527214570
62PhosphorylationSRSSTSTSPSARDDS
CCCCCCCCCCCCCCC		19.3427214570
64PhosphorylationSSTSTSPSARDDSFA
CCCCCCCCCCCCCCC		35.3919795423
69PhosphorylationSPSARDDSFAVPDGK
CCCCCCCCCCCCCCC		21.2824930733
76UbiquitinationSFAVPDGKDENTRLR
CCCCCCCCCCCHHHH		70.0623749301
412UbiquitinationYALAIDGKAPKIFAK
EEEEECCCCCCEECC		58.7424961812
448PhosphorylationYMNVSSGSAKIFNYF
CCCCCCCCHHHHHHH		28.4721440633
594UbiquitinationERLKSNGKNMEWFYE
HHHHHCCCCHHHHHH		58.3223749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DIP5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DIP5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DIP5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DIP5_YEASTDIP5physical
18467557
ALY2_YEASTALY2physical
20956561
AATC_YEASTAAT2genetic
21623372
IDH2_YEASTIDH2genetic
21623372
DHOM_YEASTHOM6genetic
21623372
MET22_YEASTMET22genetic
21623372
IDH1_YEASTIDH1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
THDH_YEASTILV1genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
LCB4_YEASTLCB4genetic
21623372
COQ4_YEASTCOQ4genetic
21623372
ACON_YEASTACO1genetic
21623372
ACON2_YEASTACO2genetic
21623372
GNP1_YEASTGNP1physical
22844449
DIP5_YEASTDIP5physical
22844449
MEP1_YEASTMEP1physical
22844449
MEP2_YEASTMEP2physical
22844449
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
APC11_YEASTAPC11genetic
27708008
GNA1_YEASTGNA1genetic
27708008
ARP4_YEASTARP4genetic
27708008
HSP77_YEASTSSC1genetic
27708008
SSL1_YEASTSSL1genetic
27708008
MED14_YEASTRGR1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
LST8_YEASTLST8genetic
27708008
PROF_YEASTPFY1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DIP5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-18 AND SER-22,AND MASS SPECTROMETRY.

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