VPS20_YEAST - dbPTM
VPS20_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS20_YEAST
UniProt AC Q04272
Protein Name Vacuolar protein sorting-associated protein 20
Gene Name VPS20
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 221
Subcellular Localization Endosome membrane
Peripheral membrane protein. Vacuole membrane
Peripheral membrane protein.
Protein Description Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Required for the oligomerization of SNF7 into a membrane-associated filament. The VPS20-SNF7 subcomplex is responsible for the membrane association of the ESCRT-III complex. Also required for the RIM101 repressor proteolytic activation..
Protein Sequence MGQKSSKVHITKTDRAILEVKRSKDEIHKFTRRTDNLILVEKSQLKDLIRKNPENYKSNMKVRFLLKRIHYQEHLLQQASDQLINLENMVSTLEFKMVEKQFINGLKNGNEILKKLNKEFSNVDELMDDVQDQIAYQNEINETLSRSLVGTSNYEDDLDKELDALESELNPEKMNNAKVANMPSTEGLPSLPQGEQTEQKEREEFATEERSDTKEPLALLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2N-myristoyl glycine------MGQKSSKVH
------CCCCCCCEE		43.56-
2Myristoylation------MGQKSSKVH
------CCCCCCCEE		43.569748261
43PhosphorylationNLILVEKSQLKDLIR
CEEEEEHHHHHHHHH		27.5215665377
184PhosphorylationAKVANMPSTEGLPSL
CCCCCCCCCCCCCCC		28.4624909858
185PhosphorylationKVANMPSTEGLPSLP
CCCCCCCCCCCCCCC		28.3527214570
200UbiquitinationQGEQTEQKEREEFAT
CCCCCCHHHHHHHHC		53.1323749301
207PhosphorylationKEREEFATEERSDTK
HHHHHHHCCCCCCCC		43.6424961812
211PhosphorylationEFATEERSDTKEPLA
HHHCCCCCCCCCCCH		53.5724961812
213PhosphorylationATEERSDTKEPLALL
HCCCCCCCCCCCHHC		38.2624961812
214UbiquitinationTEERSDTKEPLALLS
CCCCCCCCCCCHHCC		63.4323749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS20_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS20_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS20_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ASK1_YEASTASK1physical
10688190
SNF7_YEASTSNF7physical
12194858
SNF7_YEASTSNF7physical
12194857
VPS24_YEASTVPS24physical
12194858
VPS24_YEASTVPS24physical
12194857
SNF8_YEASTSNF8physical
15086794
VPS28_YEASTVPS28physical
15086794
SNF7_YEASTSNF7physical
15086794
VPS36_YEASTVPS36physical
15086794
PACC_YEASTRIM101genetic
16024810
VPS25_YEASTVPS25physical
11283351
VPS36_YEASTVPS36physical
11283351
TAF11_YEASTTAF11physical
11283351
VPS4_YEASTVPS4physical
17408385
VPS25_YEASTVPS25physical
18719252
SNF8_YEASTSNF8physical
18719252
VPS28_YEASTVPS28physical
18719252
VPS36_YEASTVPS36physical
18719252
VPS4_YEASTVPS4physical
19591838
2ABA_YEASTCDC55genetic
19254955
BUD31_YEASTBUD31genetic
20093466
HXKB_YEASTHXK2genetic
20093466
CTU1_YEASTNCS6genetic
20093466
OTU2_YEASTOTU2genetic
20093466
SKN7_YEASTSKN7genetic
20093466
VPS24_YEASTVPS24physical
20110351
SNF8_HUMANSNF8physical
16371348
SNF8_YEASTSNF8physical
16371348
VPS36_YEASTVPS36physical
16371348
SMF1_YEASTSMF1genetic
15166140
VPS4_YEASTVPS4physical
18194652
VPS4_YEASTVPS4genetic
18794364
SRS2_YEASTSRS2genetic
21459050
ATN1_YEASTENA1genetic
18395523
MYO1_YEASTMYO1physical
22875988
CANB_YEASTCNB1genetic
23933635
ATC1_YEASTPMR1genetic
23933635
PACC_YEASTRIM101genetic
23933635
NRG1_YEASTNRG1genetic
23933635
TRS20_YEASTTRS20genetic
27708008
TRS23_YEASTTRS23genetic
27708008
BUD31_YEASTBUD31genetic
27708008
PALF_YEASTRIM8genetic
27708008
RIR3_YEASTRNR3genetic
27708008
VPS24_YEASTVPS24genetic
27708008
VPS27_YEASTVPS27genetic
27708008
VPS4_YEASTVPS4genetic
27708008
KPC1_YEASTPKC1genetic
27708008
ARPC1_YEASTARC40genetic
27708008
SNU23_YEASTSNU23genetic
27708008
DPOD_YEASTPOL3genetic
27708008
UBC3_YEASTCDC34genetic
27708008
LCB2_YEASTLCB2genetic
27708008
RIFK_YEASTFMN1genetic
27708008
ACT_YEASTACT1genetic
27708008
RSC8_YEASTRSC8genetic
27708008
STT3_YEASTSTT3genetic
27708008
DUO1_YEASTDUO1genetic
27708008
SLD3_YEASTSLD3genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
XPO1_YEASTCRM1genetic
27708008
BRL1_YEASTBRL1genetic
27708008
CTF8_YEASTCTF8genetic
27708008
RHO3_YEASTRHO3genetic
27708008
ARP4_YEASTARP4genetic
27708008
NEP1_YEASTEMG1genetic
27708008
ORC1_YEASTORC1genetic
27708008
TAF7_YEASTTAF7genetic
27708008
LIP1_YEASTLIP1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DBP6_YEASTDBP6genetic
27708008
RRS1_YEASTRRS1genetic
27708008
HRR25_YEASTHRR25genetic
27708008
NIP7_YEASTNIP7genetic
27708008
IF6_YEASTTIF6genetic
27708008
IWS1_YEASTSPN1genetic
27708008
MED10_YEASTNUT2genetic
27708008
VPS8_YEASTVPS8genetic
27708008
TPS1_YEASTTPS1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
NRG1_YEASTNRG1genetic
27708008
SAC7_YEASTSAC7genetic
27708008
ODPA_YEASTPDA1genetic
27708008
MET10_YEASTMET10genetic
27708008
PIB2_YEASTPIB2genetic
27708008
ATC1_YEASTPMR1genetic
27708008
CTU1_YEASTNCS6genetic
27708008
HXKB_YEASTHXK2genetic
27708008
ELP2_YEASTELP2genetic
27708008
OTU2_YEASTOTU2genetic
27708008
OPI1_YEASTOPI1genetic
27708008
GGA2_YEASTGGA2genetic
27708008
UBA4_YEASTUBA4genetic
27708008
SKN7_YEASTSKN7genetic
27708008
URM1_YEASTURM1genetic
27708008
BCK1_YEASTBCK1genetic
27708008
GSH1_YEASTGSH1genetic
27708008
TUL1_YEASTTUL1genetic
27708008
VPS9_YEASTVPS9genetic
27708008
MSC1_YEASTMSC1genetic
27708008
VPS5_YEASTVPS5genetic
27708008
YO223_YEASTDSC3genetic
27708008
ELP3_YEASTELP3genetic
27708008
TKT1_YEASTTKL1genetic
27708008
MRL1_YEASTMRL1genetic
27708008
AXL1_YEASTAXL1genetic
27708008
HDA3_YEASTHDA3genetic
27708008
SNF7_YEASTSNF7genetic
27074665
SNF7_YEASTSNF7physical
27733427
SNF8_HUMANSNF8physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS20_YEAST

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Related Literatures of Post-Translational Modification
Myristoylation
ReferencePubMed
"A role for Saccharomyces cerevisiae fatty acid activation protein 4in regulating protein N-myristoylation during entry into stationaryphase.";
Ashrafi K., Farazi T.A., Gordon J.I.;
J. Biol. Chem. 273:25864-25874(1998).
Cited for: MYRISTOYLATION AT GLY-2.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND MASSSPECTROMETRY.

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