| UniProt ID | SLD3_YEAST | |
|---|---|---|
| UniProt AC | P53135 | |
| Protein Name | DNA replication regulator SLD3 | |
| Gene Name | SLD3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 668 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Required for loading and maintenance of stable association of CDC45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Required for the association of PSF1 with origins.. | |
| Protein Sequence | METWEVIASVKEATKGLDLSLDHPLIIKSEDVPSNILQLLQQKNRRQLKHICMKSRKEYFLLEEYGPGFWVKWPYNYFNGYSLPERRTEVVTTVERERAKRETLKTWDELKFKELLHLWSEEPKGSCKLEKDKDLKLDMNPPDMKGESKINDYYSDPKEYIESKYYDALFSIHTPLAYFVKSNLVRLKNTCRTKYGSDSYKIAYQAMLQKFLLSIVQFKDRHDNRLLLEPFSSPIADEKRKNCLTKFVIQDENKNSSTIADLCVVLKSREIKLQILLLLEIIGLNDLDWNFRDFEKKYKLKLKKRSLNLTKKGLVRRRSKKKTSEKDKGIERITTSLDYCEQLDLYLDRACILDILLSSETPNPDAIEASNGTIQEHKKNILDKSKEASLVGFINYVLIPYFNKKVPHAVEFIIQKLKGPSMRPKRALKKVNDSTNVSSPNTVETYNRLSTSQRASRSSIINSVPSSPALRRVDANLFSRKSIASPTPELLNSRTNSNLNEFLESETRSLKRPSQLGRTKSDLTMNHLQKRQFSVSDLSTTRVPNSSTITLKTPFSHSTINAYKTMNNSFRRVGKRKDINETIRLHERVDSEENVQVQATPAVKKRTVTPNKKAQLQSIIESPLNFKDDDTHEGRKNTSNITSTPTNKPPENSSKRRVRRRLFAPEST | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 153 | Phosphorylation | GESKINDYYSDPKEY CCHHCCCCCCCHHHH | 10.61 | 20865002 | |
| 154 | Phosphorylation | ESKINDYYSDPKEYI CHHCCCCCCCHHHHH | 14.95 | 20865002 | |
| 165 | Phosphorylation | KEYIESKYYDALFSI HHHHHHHHHHHHHCC | 18.83 | 27017623 | |
| 166 | Phosphorylation | EYIESKYYDALFSIH HHHHHHHHHHHHCCC | 9.85 | 27017623 | |
| 174 | Phosphorylation | DALFSIHTPLAYFVK HHHHCCCCCHHHHHH | 20.51 | 27017623 | |
| 306 | Phosphorylation | KLKLKKRSLNLTKKG HHHHHHHHCCCCHHH | 30.41 | 20835227 | |
| 310 | Phosphorylation | KKRSLNLTKKGLVRR HHHHCCCCHHHHHHH | 29.63 | 20835227 | |
| 370 | Phosphorylation | NPDAIEASNGTIQEH CCHHHHHCCCCHHHH | 24.01 | 20865002 | |
| 373 | Phosphorylation | AIEASNGTIQEHKKN HHHHCCCCHHHHHHH | 24.60 | 20865002 | |
| 379 | Acetylation | GTIQEHKKNILDKSK CCHHHHHHHHHCHHH | 51.64 | 22865919 | |
| 384 | Acetylation | HKKNILDKSKEASLV HHHHHHCHHHHHHHH | 61.04 | 25381059 | |
| 421 | Phosphorylation | IQKLKGPSMRPKRAL HHHHCCCCCCHHHHH | 35.77 | 20835227 | |
| 434 | Phosphorylation | ALKKVNDSTNVSSPN HHHHHCCCCCCCCCC | 19.37 | 20835227 | |
| 435 | Phosphorylation | LKKVNDSTNVSSPNT HHHHCCCCCCCCCCH | 42.37 | 20835227 | |
| 438 | Phosphorylation | VNDSTNVSSPNTVET HCCCCCCCCCCHHHH | 41.99 | 20835227 | |
| 439 | Phosphorylation | NDSTNVSSPNTVETY CCCCCCCCCCHHHHH | 20.20 | 23749301 | |
| 442 | Phosphorylation | TNVSSPNTVETYNRL CCCCCCCHHHHHHHC | 24.09 | 20835227 | |
| 445 | Phosphorylation | SSPNTVETYNRLSTS CCCCHHHHHHHCCHH | 23.04 | 20835227 | |
| 450 | Phosphorylation | VETYNRLSTSQRASR HHHHHHCCHHHHHCC | 23.83 | 20835227 | |
| 451 | Phosphorylation | ETYNRLSTSQRASRS HHHHHCCHHHHHCCH | 33.21 | 20865002 | |
| 452 | Phosphorylation | TYNRLSTSQRASRSS HHHHCCHHHHHCCHH | 17.81 | 20835227 | |
| 456 | Phosphorylation | LSTSQRASRSSIINS CCHHHHHCCHHHHHC | 34.58 | 20865002 | |
| 458 | Phosphorylation | TSQRASRSSIINSVP HHHHHCCHHHHHCCC | 24.32 | 20835227 | |
| 459 | Phosphorylation | SQRASRSSIINSVPS HHHHCCHHHHHCCCC | 26.78 | 28889911 | |
| 463 | Phosphorylation | SRSSIINSVPSSPAL CCHHHHHCCCCCHHH | 25.62 | 20865002 | |
| 466 | Phosphorylation | SIINSVPSSPALRRV HHHHCCCCCHHHHHC | 46.96 | 20865002 | |
| 467 | Phosphorylation | IINSVPSSPALRRVD HHHCCCCCHHHHHCC | 14.23 | 25752575 | |
| 479 | Phosphorylation | RVDANLFSRKSIASP HCCCCCCCCCCCCCC | 41.80 | 20835227 | |
| 482 | Phosphorylation | ANLFSRKSIASPTPE CCCCCCCCCCCCCHH | 23.44 | 20835227 | |
| 493 | Phosphorylation | PTPELLNSRTNSNLN CCHHHHHHCCCCCHH | 40.21 | 20865002 | |
| 495 | Phosphorylation | PELLNSRTNSNLNEF HHHHHHCCCCCHHHH | 42.70 | 20865002 | |
| 497 | Phosphorylation | LLNSRTNSNLNEFLE HHHHCCCCCHHHHHH | 41.92 | 20865002 | |
| 505 | Phosphorylation | NLNEFLESETRSLKR CHHHHHHHHHHHCCC | 46.55 | 20865002 | |
| 507 | Phosphorylation | NEFLESETRSLKRPS HHHHHHHHHHCCCHH | 34.53 | 20865002 | |
| 509 | Phosphorylation | FLESETRSLKRPSQL HHHHHHHHCCCHHHC | 45.74 | 20835227 | |
| 514 | Phosphorylation | TRSLKRPSQLGRTKS HHHCCCHHHCCCCHH | 41.91 | 20835227 | |
| 519 | Phosphorylation | RPSQLGRTKSDLTMN CHHHCCCCHHHCCHH | 32.85 | 17287358 | |
| 521 | Phosphorylation | SQLGRTKSDLTMNHL HHCCCCHHHCCHHHH | 36.92 | 17287358 | |
| 524 | Phosphorylation | GRTKSDLTMNHLQKR CCCHHHCCHHHHHHC | 22.40 | 20835227 | |
| 534 | Phosphorylation | HLQKRQFSVSDLSTT HHHHCCEEHHHCCCC | 16.63 | 20865002 | |
| 539 | Phosphorylation | QFSVSDLSTTRVPNS CEEHHHCCCCCCCCC | 32.49 | 20835227 | |
| 540 | Phosphorylation | FSVSDLSTTRVPNSS EEHHHCCCCCCCCCC | 26.39 | 20835227 | |
| 541 | Phosphorylation | SVSDLSTTRVPNSST EHHHCCCCCCCCCCE | 26.71 | 20835227 | |
| 546 | Phosphorylation | STTRVPNSSTITLKT CCCCCCCCCEEEEEC | 23.84 | 20835227 | |
| 547 | Phosphorylation | TTRVPNSSTITLKTP CCCCCCCCEEEEECC | 30.39 | 20835227 | |
| 548 | Phosphorylation | TRVPNSSTITLKTPF CCCCCCCEEEEECCC | 20.15 | 20835227 | |
| 550 | Phosphorylation | VPNSSTITLKTPFSH CCCCCEEEEECCCCH | 23.45 | 20835227 | |
| 556 | Phosphorylation | ITLKTPFSHSTINAY EEEECCCCHHHHHHH | 20.10 | 20835227 | |
| 558 | Phosphorylation | LKTPFSHSTINAYKT EECCCCHHHHHHHHH | 29.77 | 20835227 | |
| 559 | Phosphorylation | KTPFSHSTINAYKTM ECCCCHHHHHHHHHH | 16.90 | 20835227 | |
| 565 | Phosphorylation | STINAYKTMNNSFRR HHHHHHHHHCCCHHH | 16.68 | 20835227 | |
| 569 | Phosphorylation | AYKTMNNSFRRVGKR HHHHHCCCHHHCCCC | 18.35 | 20835227 | |
| 582 | Phosphorylation | KRKDINETIRLHERV CCCCHHHHHHHHHCC | 13.60 | 20865002 | |
| 591 | Phosphorylation | RLHERVDSEENVQVQ HHHHCCCCCCCEEEE | 43.91 | 20865002 | |
| 600 | Phosphorylation | ENVQVQATPAVKKRT CCEEEEECCCCCCCC | 8.49 | 17167417 | |
| 607 | Phosphorylation | TPAVKKRTVTPNKKA CCCCCCCCCCCCCHH | 37.30 | 20865002 | |
| 609 | Phosphorylation | AVKKRTVTPNKKAQL CCCCCCCCCCCHHHH | 22.11 | 20865002 | |
| 618 | Phosphorylation | NKKAQLQSIIESPLN CCHHHHHHHHHCCCC | 33.84 | 20865002 | |
| 622 | Phosphorylation | QLQSIIESPLNFKDD HHHHHHHCCCCCCCC | 25.03 | 17167417 | |
| 631 | Phosphorylation | LNFKDDDTHEGRKNT CCCCCCCCCCCCCCC | 28.90 | 20865002 | |
| 638 | Phosphorylation | THEGRKNTSNITSTP CCCCCCCCCCCCCCC | 26.62 | 20865002 | |
| 639 | Phosphorylation | HEGRKNTSNITSTPT CCCCCCCCCCCCCCC | 35.31 | 20865002 | |
| 642 | Phosphorylation | RKNTSNITSTPTNKP CCCCCCCCCCCCCCC | 30.69 | 20865002 | |
| 643 | Phosphorylation | KNTSNITSTPTNKPP CCCCCCCCCCCCCCC | 28.70 | 21551504 | |
| 644 | Phosphorylation | NTSNITSTPTNKPPE CCCCCCCCCCCCCCC | 26.02 | 23749301 | |
| 646 | Phosphorylation | SNITSTPTNKPPENS CCCCCCCCCCCCCCC | 56.83 | 20865002 | |
| 653 | Phosphorylation | TNKPPENSSKRRVRR CCCCCCCCCHHHHHH | 35.26 | 20835227 | |
| 654 | Phosphorylation | NKPPENSSKRRVRRR CCCCCCCCHHHHHHH | 41.59 | 20835227 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SLD3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLD3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLD3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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