SML1_YEAST - dbPTM
SML1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SML1_YEAST
UniProt AC Q04964
Protein Name Ribonucleotide reductase inhibitor protein SML1
Gene Name SML1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 104
Subcellular Localization Nucleus . Cytoplasm .
Protein Description Strong inhibitor of ribonucleotide reductase (RNR1) and is involved in regulating dNTP production..
Protein Sequence MQNSQDYFYAQNRCQQQQAPSTLRTVTMAEFRRVPLPPMAEVPMLSTQNSMGSSASASASSLEMWEKDLEERLNSIDHDMNNNKFGSGELKSMFNQGKVEEMDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MQNSQDYF
-------CCCHHHHH		8.4222814378
27PhosphorylationPSTLRTVTMAEFRRV
CCCCCEEEHHHHCCC		15.2827017623
56PhosphorylationNSMGSSASASASSLE
CCCCCCCCCCHHHHH		25.3828889911
58PhosphorylationMGSSASASASSLEMW
CCCCCCCCHHHHHHH		26.6228889911
60PhosphorylationSSASASASSLEMWEK
CCCCCCHHHHHHHHH		32.7228889911
75PhosphorylationDLEERLNSIDHDMNN
HHHHHHHHCCCCCCC		33.7022369663
84UbiquitinationDHDMNNNKFGSGELK
CCCCCCCCCCHHHHH		53.9124961812
84AcetylationDHDMNNNKFGSGELK
CCCCCCCCCCHHHHH		53.9124489116
87PhosphorylationMNNNKFGSGELKSMF
CCCCCCCHHHHHHHH		32.0222369663
91UbiquitinationKFGSGELKSMFNQGK
CCCHHHHHHHHHCCC		35.2623749301
91AcetylationKFGSGELKSMFNQGK
CCCHHHHHHHHHCCC		35.2624489116
92PhosphorylationFGSGELKSMFNQGKV
CCHHHHHHHHHCCCC		41.0321440633
98UbiquitinationKSMFNQGKVEEMDF-
HHHHHCCCCEECCC-		36.3923749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
56SPhosphorylationKinaseDUN1P39009
Uniprot
58SPhosphorylationKinaseDUN1P39009
Uniprot
60SPhosphorylationKinaseDUN1P39009
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SML1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SML1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ADT3_YEASTAAC3physical
11805837
PFKA1_YEASTPFK1physical
11805837
HIR3_YEASTHIR3physical
11805837
DUN1_YEASTDUN1physical
11805837
HSP7E_YEASTECM10physical
11805837
PYC1_YEASTPYC1physical
11805837
GPP2_YEASTGPP2physical
11805837
NAT1_YEASTNAT1physical
11805837
ATPG_YEASTATP3physical
11805837
ADH3_YEASTADH3physical
11805837
PHSG_YEASTGPH1physical
11805837
RNQ1_YEASTRNQ1physical
11805837
SML1_YEASTSML1physical
11811965
RIR1_YEASTRNR1physical
10593972
PIF1_YEASTPIF1genetic
11429610
DUN1_YEASTDUN1genetic
11904430
LCD1_YEASTLCD1genetic
10950868
ATM_YEASTTEL1genetic
11707419
SET1_YEASTSET1genetic
11459833
H3_YEASTHHT1genetic
16020781
IRA1_YEASTIRA1physical
16554755
NUP42_YEASTNUP42physical
16554755
SEC20_YEASTSEC20physical
16554755
TBB_YEASTTUB2physical
16554755
SPT6_YEASTSPT6physical
16554755
COQ6_YEASTCOQ6physical
16554755
ZAP1_YEASTZAP1physical
16554755
AIM26_YEASTAIM26physical
16554755
APC9_YEASTAPC9physical
16554755
PEP3_YEASTPEP3physical
16554755
FMP27_YEASTFMP27physical
16554755
APC1_YEASTAPC1physical
16554755
MID1_YEASTMID1physical
16554755
ZIM17_YEASTZIM17physical
16554755
TOP1_YEASTTOP1physical
16554755
REV1_YEASTREV1physical
16554755
BEM3_YEASTBEM3physical
16554755
MDM36_YEASTMDM36physical
16554755
WTM2_YEASTWTM2genetic
16452505
RAD53_YEASTRAD53genetic
17721079
DIF1_YEASTDIF1genetic
18851834
SML1_YEASTSML1physical
19086274
ATR_YEASTMEC1genetic
19838171
RAD53_YEASTRAD53genetic
19838171
DUN1_YEASTDUN1genetic
19838171
ATR_YEASTMEC1genetic
20865002
H3_YEASTHHT1genetic
18579506
RAD52_YEASTRAD52genetic
21952045
RAD53_YEASTRAD53genetic
22927468
RAD53_YEASTRAD53genetic
15687272
NDD1_YEASTNDD1genetic
24324011
MMS4_YEASTMMS4genetic
23531881
ISW2_YEASTISW2genetic
25701287
NHP10_YEASTNHP10genetic
25701287
RIR1_YEASTRNR1physical
27155231
AEP2_YEASTAEP2genetic
27708008
HMI1_YEASTHMI1genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
DCC1_YEASTDCC1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
GPR1_YEASTGPR1genetic
27708008
AIM11_YEASTAIM11genetic
27708008
MED20_YEASTSRB2genetic
27708008
CTF8_YEASTCTF8genetic
27708008
FLX1_YEASTFLX1genetic
27708008
REV7_YEASTREV7genetic
27708008
RAV1_YEASTRAV1genetic
27708008
RM49_YEASTMRP49genetic
27708008
LDB18_YEASTLDB18genetic
27708008
PFD6_YEASTYKE2genetic
27708008
CDC73_YEASTCDC73genetic
27708008
PET8_YEASTPET8genetic
27708008
SWS2_YEASTSWS2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
2A5D_YEASTRTS1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
LIPA_YEASTLIP5genetic
27708008
ARL3_YEASTARL3genetic
27708008
NIP80_YEASTNIP100genetic
27708008
NEW1_YEASTNEW1genetic
27708008
ATR_YEASTMEC1genetic
26733669
RAD53_YEASTRAD53genetic
26733669
UME6_YEASTUME6genetic
28468907
PIF1_YEASTPIF1genetic
26411679
RRM3_YEASTRRM3genetic
26411679
SAC3_YEASTSAC3genetic
26411679
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SML1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Identification of phosphorylation sites on the yeast ribonucleotidereductase inhibitor Sml1.";
Uchiki T., Dice L.T., Hettich R.L., Dealwis C.;
J. Biol. Chem. 279:11293-11303(2004).
Cited for: PHOSPHORYLATION AT SER-56; SER-58 AND SER-60.

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