| UniProt ID | ATM_YEAST | |
|---|---|---|
| UniProt AC | P38110 | |
| Protein Name | Serine/threonine-protein kinase TEL1 | |
| Gene Name | TEL1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 2787 | |
| Subcellular Localization | Nucleus . Chromosome, telomere . Localizes to nuclear DNA repair foci in response to DNA double strand breaks. | |
| Protein Description | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited by the MRX-complex to sites of DNA lesions immediately after damage to initiate non-homologous end-joining (NHEJ). Subsequently displaced by the RPA complex in a reaction probably involving the SAE2 protein. Phosphorylates MRE11 and XRS2, 2 subunits of the MRX-complex. The phosphorylation of MRE11 is a feedback response from the checkpoint signaling pathway. Phosphorylates RAD9, CHK1 and RAD53, leading to the activation of the CHK1 and RAD23 kinases involved in the DNA damage response cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are involved in genome stability. Required for the control of telomere length and genome stability.. | |
| Protein Sequence | MEDHGIVETLNFLSSTKIKERNNALDELTTILKEDPERIPTKALSTTAEALVELLASEHTKYCDLLRNLTVSTTNKLSLSENRLSTISYVLRLFVEKSCERFKVKTLKLLLAVVPELMVKDGSKSLLDAVSVHLSFALDALIKSDPFKLKFMIHQWISLVDKICEYFQSQMKLSMVDKTLTNFISILLNLLALDTVGIFQVTRTITWTVIDFLRLSKKENGNTRLIMSLINQLILKCHCFSVIDTLMLIKEAWSYNLTIGCTSNELVQDQLSLFDVMSSELMNHKLPYMIGQENYVEELRSESLVSLYREYILLRLSNYKPQLFTVNHVEFSYIRGSRDKNSWFALPDFRLRDRGGRSVWLKILGITKSLLTYFALNRKNENYSLLFKRRKCDSDIPSILRISDDMDTFLIHLLEENSSHEFEVLGLQLCSFYGTLQDFTKSFAEQLKELLFSKFEKIQCFNWVCFSFIPLLSQKECELSNGDMARLFKVCLPLVKSNESCQLSCLLLANSIKFSKQLLSDEKTINQIYDLYELSDILGPILVTNESFMLWGYLQYVGKDFQSMNGISSADRIFEWLKSKWNQLRGTDAKQDQFCNFISWLGNKYDPENPFNDKKGEGANPVSLCWDESHKIWQHFQEQREFLLGVKPEEKSECFNTPFFNLPKVSLDLTRYNEILYRLLENIESDAFSSPLQKFTWVAKLIQIVDNLCGDSTFSEFIAAYKRTTLITIPQLSFDSQNSYQSFFEEVLSIRTINVDHLVLDKINMKEIVNDFIRMQKNKSQTGTSAINYFEASSEDTTQNNSPYTIGGRFQKPLHSTIDKAVRAYLWSSRNKSISERLVAILEFSDCVSTDVFISYLGTVCQWLKQAIGEKSSYNKILEEFTEVLGEKLLCNHYSSSNQAMLLLTSYIEAIRPQWLSYPEQPLNSDCNDILDWIISRFEDNSFTGVAPTVNLSMLLLSLLQNHDLSHGSIRGGKQRVFATFIKCLQKLDSSNIINIMNSISSYMAQVSYKNQSIIFYEIKSLFGPPQQSIEKSAFYSLAMSMLSLVSYPSLVFSLEDMMTYSGFNHTRAFIQQALNKITVAFRYQNLTELFEYCKFDLIMYWFNRTKVPTSKLEKEWDISLFGFADIHEFLGRYFVEISAIYFSQGFNQKWILDMLHAITGNGDAYLVDNSYYLCIPLAFISGGVNELIFDILPQISGKTTVKYHKKYRLLMLKWIIRFTDLGSLTELRSTVEKLFPTSYLSPYLFENSSVSMRYQYPLHIPLALGATLVQTQFAHEKNNTHEFKLLFLSVITDLEKTSTYIGKLRCARELKYLFVLYENVLVKSSTLNFIIIRLSKFLIDTQIHDEVITIFSSLLNLADKNTFEIEPSLPNLFCKIFIYLRENKQLSPSFQQAIKLLEHRDLIKIKTWKYCLDAIFGNIVQDDIYENTELLDASDCGVDDVVLVSLLFSYARRPVASKIGCSLSKAAAINILKHHVPKEYLSKNFKLWFAALSRRILQQEVQRERSTNFNNEVHLKNFEMVFRHPEQPHMIYQRISTFNKEAELYDSTEVFFISECILTYLVGYSIGNSESEFCFRDNIMNENKDKVAPLDKDVLNAIYPLANNFGMESFICDTYLSVNEPYNCWLSKFARSLIHQISFNIPPIVCLYPLCKGSTAFCELVLTDLFFLSTTYDPKSCLNWSNRIFTQIAMLLHVKDSEIKLKMLFNVIKMIRMGSRCKERNCLRIYSSLDLQEICQISLKIKEFKFGYLLFEEMNMPNIREMNINTLQKIYECINDGDFLAGLPVPHSIEGVLNSINRIDSDTWKRFLFNNADFDANYTTSLEEEKESLIKATEDSGFYGLTSLLESRLSGSSDVYKWNLELGDWKLLTPKVVDSKAKGLYYAIKNLPQDVGFAEKSLEKSLLTIFDSRQHFISQTEWMDTLNAIIEFIKIAAIPQDVTSFPQTLMSIMKADKERLNTIDFYDHKTTLKSRHTLMNVLSRNSLDENVKCSKYLRLGSIIQLANYVQLAIANGAPQDALRNATLMSKTVKNIAKLYDDPSVVSQIEKLASFTSANALWESREYKAPVMIMRDLLAQNEKNISESILYDDFKLLINVPMDQIKARLVKWSSESRLEPAAAIYEKIIVNWDINVEDHESCSDVFYTLGSFLDEQAQKLRSNGEIEDREHRSYTGKSTLKALELIYKNTKLPENERKDAKRHYNRVLLQYNRDSEVLKALLLQKEKFLWHALHFYLNTLVFSNRYDNDIIDKFCGLWFENDDNSKINQLLYKEIGTIPSWKFLPWVNQIASKISMEENEFQKPLQLTMKRLLYKLPYDSLYSVMSILLYEKQSNKDTNISQKIQAVKKILLELQGYDRGAFAKKYLLPVQEFCEMSVELANLKFVQNTKTLRLANLKIGQYWLKQLNMEKLPLPTSNFTVKSSADGRKARPYIVSVNETVGITTTGLSLPKIVTFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDKITFDQARKGMKAVQTKSNEERLKAYLKITNEIKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPLYSWVMSPVKKYEHLFEEEHEITNFDNVSKFISNNDRNENQESYRALKGVEEKLMGNGLSVESSVQDLIQQATDPSNLSVIYMGWSPFY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | Phosphorylation | IPTKALSTTAEALVE CCCHHHHCHHHHHHH | 30.76 | 27017623 | |
| 689 | Phosphorylation | NIESDAFSSPLQKFT CCCCCCCCCHHHHHH | 32.54 | 28889911 | |
| 690 | Phosphorylation | IESDAFSSPLQKFTW CCCCCCCCHHHHHHH | 24.15 | 28889911 | |
| 1931 | Ubiquitination | NAIIEFIKIAAIPQD HHHHHHHHHHCCCCC | 31.45 | 19722269 | |
| 2082 | Phosphorylation | AQNEKNISESILYDD HHCCCCCCHHHHHCC | 34.38 | 19823750 | |
| 2084 | Phosphorylation | NEKNISESILYDDFK CCCCCCHHHHHCCHH | 15.88 | 19823750 | |
| 2087 | Phosphorylation | NISESILYDDFKLLI CCCHHHHHCCHHHHH | 16.28 | 19823750 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ATM_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATM_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATM_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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