TERT_YEAST - dbPTM
TERT_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TERT_YEAST
UniProt AC Q06163
Protein Name Telomerase reverse transcriptase
Gene Name EST2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 884
Subcellular Localization Nucleus. Chromosome, telomere.
Protein Description Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme..
Protein Sequence MKILFEFIQDKLDIDLQTNSTYKENLKCGHFNGLDEILTTCFALPNSRKIALPCLPGDLSHKAVIDHCIIYLLTGELYNNVLTFGYKIARNEDVNNSLFCHSANVNVTLLKGAAWKMFHSLVGTYAFVDLLINYTVIQFNGQFFTQIVGNRCNEPHLPPKWAQRSSSSSATAAQIKQLTEPVTNKQFLHKLNINSSSFFPYSKILPSSSSIKKLTDLREAIFPTNLVKIPQRLKVRINLTLQKLLKRHKRLNYVSILNSICPPLEGTVLDLSHLSRQSPKERVLKFIIVILQKLLPQEMFGSKKNKGKIIKNLNLLLSLPLNGYLPFDSLLKKLRLKDFRWLFISDIWFTKHNFENLNQLAICFISWLFRQLIPKIIQTFFYCTEISSTVTIVYFRHDTWNKLITPFIVEYFKTYLVENNVCRNHNSYTLSNFNHSKMRIIPKKSNNEFRIIAIPCRGADEEEFTIYKENHKNAIQPTQKILEYLRNKRPTSFTKIYSPTQIADRIKEFKQRLLKKFNNVLPELYFMKFDVKSCYDSIPRMECMRILKDALKNENGFFVRSQYFFNTNTGVLKLFNVVNASRVPKPYELYIDNVRTVHLSNQDVINVVEMEIFKTALWVEDKCYIREDGLFQGSSLSAPIVDLVYDDLLEFYSEFKASPSQDTLILKLADDFLIISTDQQQVINIKKLAMGGFQKYNAKANRDKILAVSSQSDDDTVIQFCAMHIFVKELEVWKHSSTMNNFHIRSKSSKGIFRSLIALFNTRISYKTIDTNLNSTNTVLMQIDHVVKNISECYKSAFKDLSINVTQNMQFHSFLQRIIEMTVSGCPITKCDPLIEYEVRFTILNGFLESLSSNTSKFKDNIILLRKEIQHLQAYIYIYIHIVN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationDLQTNSTYKENLKCG
CCCCCCCHHHHCCCC		19.0021440633
169PhosphorylationAQRSSSSSATAAQIK
HCCCCCCCCCHHHHH		31.4228889911
171PhosphorylationRSSSSSATAAQIKQL
CCCCCCCCHHHHHHH		25.1928889911
201PhosphorylationNSSSFFPYSKILPSS
CCCCCCCHHHCCCCC		19.8928889911
202PhosphorylationSSSFFPYSKILPSSS
CCCCCCHHHCCCCCC		17.2928889911
207PhosphorylationPYSKILPSSSSIKKL
CHHHCCCCCCHHHHH		39.1328889911
208PhosphorylationYSKILPSSSSIKKLT
HHHCCCCCCHHHHHH		26.6027214570
209PhosphorylationSKILPSSSSIKKLTD
HHCCCCCCHHHHHHH		40.1827214570
210PhosphorylationKILPSSSSIKKLTDL
HCCCCCCHHHHHHHH		40.1328889911
215PhosphorylationSSSIKKLTDLREAIF
CCHHHHHHHHHHHHC		41.7028889911
491PhosphorylationYLRNKRPTSFTKIYS
HHHHCCCCCCCCCCC		40.2727017623
537PhosphorylationDVKSCYDSIPRMECM
CHHHHHHCCCHHHHH		14.1717563356
581PhosphorylationLFNVVNASRVPKPYE
EEEEECHHCCCCCEE		28.7126447709
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TERT_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TERT_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TERT_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EST1_YEASTEST1physical
12454059
EST3_YEASTEST3genetic
12529422
SGS1_YEASTSGS1genetic
11248051
KU70_YEASTYKU70genetic
9635193
KU80_YEASTYKU80genetic
9635193
RAD50_YEASTRAD50genetic
11231130
NMD2_YEASTNMD2genetic
14701754
STN1_YEASTSTN1genetic
12582130
EXO1_YEASTEXO1genetic
15126387
PIF1_YEASTPIF1genetic
16878131
EST1_YEASTEST1physical
16862158
EST3_YEASTEST3physical
16862158
PIN4_YEASTPIN4genetic
17636027
HSP82_YEASTHSP82physical
17954556
EST1_YEASTEST1genetic
18273059
RAD52_YEASTRAD52genetic
18830407
RAD52_YEASTRAD52genetic
19380905
RAD52_YEASTRAD52genetic
19942858
TOR1_YEASTTOR1genetic
19557187
SIR2_YEASTSIR2genetic
19557187
FOB1_YEASTFOB1genetic
19557187
PIF1_YEASTPIF1genetic
19704012
EST1_YEASTEST1genetic
21220516
EST3_YEASTEST3physical
21659533
RAD52_YEASTRAD52genetic
22071150
MEC3_YEASTMEC3genetic
22071150
RAD24_YEASTRAD24genetic
22071150
PXR1_YEASTPXR1physical
14977919
RUVB2_YEASTRVB2physical
22100294
RUVB1_YEASTRVB1physical
22100294
RFA2_YEASTRFA2physical
22354040
RFA1_YEASTRFA1physical
22354040
EST1_YEASTEST1physical
22847816
RAD52_YEASTRAD52genetic
23028367
SIN3_YEASTSIN3genetic
23028367
KU80_YEASTYKU80genetic
24879463
KU70_YEASTYKU70genetic
24879463
EST1_YEASTEST1physical
24879463
EST1_YEASTEST1physical
25220466
SCH9_YEASTSCH9genetic
27855118
SML1_YEASTSML1genetic
27161319
RIR1_YEASTRNR1genetic
27161319
CIK1_YEASTCIK1genetic
26205667
KAR3_YEASTKAR3genetic
26205667
EST1_YEASTEST1physical
25240060
EST3_YEASTEST3physical
25240060
MPH1_YEASTMPH1genetic
29281624
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TERT_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory