RIR1_YEAST - dbPTM
RIR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIR1_YEAST
UniProt AC P21524
Protein Name Ribonucleoside-diphosphate reductase large chain 1
Gene Name RNR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 888
Subcellular Localization Cytoplasm .
Protein Description Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides..
Protein Sequence MYVYKRDGRKEPVQFDKITARISRLCYGLDPKHIDAVKVTQRIISGVYEGVTTIELDNLAAETCAYMTTVHPDYATLAARIAISNLHKQTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDRDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSILEAQTETGTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAVCNLASVALPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQAASAAIQFTIDQKIADQATENVADISNLKRPSYMPSSASYAASDFVPAAVTANATIPSLDSSSEASREASPAPTGSHSLTKGMAELNVQESKVEVPEVPAPTKNEEKAAPIVDDEETEFDIYNSKVIACAIDNPEACEMCSG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10UbiquitinationVYKRDGRKEPVQFDK
EECCCCCCCCCCHHH		72.4123749301
17AcetylationKEPVQFDKITARISR
CCCCCHHHHHHHHHH		43.1524489116
17UbiquitinationKEPVQFDKITARISR
CCCCCHHHHHHHHHH		43.1517644757
32AcetylationLCYGLDPKHIDAVKV
HHHCCCHHHCCCHHH		53.5124489116
32UbiquitinationLCYGLDPKHIDAVKV
HHHCCCHHHCCCHHH		53.5123749301
96AcetylationQTTKQFSKVVEDLYR
HHHHHHHHHHHHHHH		52.1424489116
102PhosphorylationSKVVEDLYRYVNAAT
HHHHHHHHHHHHHHC		16.5427017623
104PhosphorylationVVEDLYRYVNAATGK
HHHHHHHHHHHHCCC		5.6327017623
109PhosphorylationYRYVNAATGKPAPMI
HHHHHHHCCCCCCCC		43.2427017623
128UbiquitinationYNIVMENKDKLNSAI
HHHHHCCCCCCCEEE		42.8217644757
130UbiquitinationIVMENKDKLNSAIVY
HHHCCCCCCCEEEEE		51.7017644757
149UbiquitinationQYSYFGFKTLERSYL
CCEECCEEECCEEEE		53.2117644757
217PhosphorylationTPKPQMSSCFLVAMK
CCCCCCCCEEEEEEC		11.9828132839
227PhosphorylationLVAMKEDSIEGIYDT
EEEECCCCHHHHHHH		24.5128889911
234PhosphorylationSIEGIYDTLKECALI
CHHHHHHHHHHHHHH		23.8228132839
243UbiquitinationKECALISKTAGGIGL
HHHHHHHHHCCCCEE		35.0917644757
257PhosphorylationLHIHNIRSTGSYIAG
EEEEECCCCCCEEEC		33.0728132839
258PhosphorylationHIHNIRSTGSYIAGT
EEEECCCCCCEEECC		21.9428132839
260PhosphorylationHNIRSTGSYIAGTNG
EECCCCCCEEECCCC		17.2928132839
261PhosphorylationNIRSTGSYIAGTNGT
ECCCCCCEEECCCCC		8.9928132839
265PhosphorylationTGSYIAGTNGTSNGL
CCCEEECCCCCCCCE		22.8128132839
268PhosphorylationYIAGTNGTSNGLIPM
EEECCCCCCCCEEEE		22.5328132839
269PhosphorylationIAGTNGTSNGLIPMI
EECCCCCCCCEEEEE		30.2328132839
292UbiquitinationYVDQGGNKRPGAFAL
EECCCCCCCCCEEEE		64.3417644757
316UbiquitinationFDFIDIRKNHGKEEI
HHHHHHHHHCCCHHH		54.3417644757
387UbiquitinationGKTIKAQKLWYSILE
CCEEEHHHHHHHHHH		45.9423749301
407UbiquitinationGTPFVVYKDACNRKS
CCCEEEEECCCCCCC		27.5217644757
413UbiquitinationYKDACNRKSNQKNLG
EECCCCCCCCCCCCC		39.5017644757
417UbiquitinationCNRKSNQKNLGVIKS
CCCCCCCCCCCEECC		59.3923749301
462PhosphorylationETSEDGKTSTYNFKK
EECCCCCCEEECHHH		31.6528889911
464PhosphorylationSEDGKTSTYNFKKLH
CCCCCCEEECHHHHH		27.9328889911
563PhosphorylationPYETFQGSPASQGIL
CCCCCCCCCCCCCEE		13.4027017623
635PhosphorylationMYSRRVLSGEFQVVN
CCCCCCCCCCCEEEC		33.1622369663
723UbiquitinationLRAPTMGKLTSMHFY
EECCCCCCCHHEEEC		37.4617644757
723AcetylationLRAPTMGKLTSMHFY
EECCCCCCCHHEEEC		37.4624489116
733UbiquitinationSMHFYGWKKGLKTGM
HEEECCCCCCCCCCC		32.3817644757
734UbiquitinationMHFYGWKKGLKTGMY
EEECCCCCCCCCCCH		64.0717644757
759UbiquitinationIQFTIDQKIADQATE
HCHHHCHHHHHHHHC		35.7917644757
772PhosphorylationTENVADISNLKRPSY
HCCCHHHHCCCCCCC		36.3424909858
775UbiquitinationVADISNLKRPSYMPS
CHHHHCCCCCCCCCC		67.5217644757
775AcetylationVADISNLKRPSYMPS
CHHHHCCCCCCCCCC		67.5224489116
778PhosphorylationISNLKRPSYMPSSAS
HHCCCCCCCCCCCHH		37.7919795423
779PhosphorylationSNLKRPSYMPSSASY
HCCCCCCCCCCCHHH		18.7419823750
782PhosphorylationKRPSYMPSSASYAAS
CCCCCCCCCHHHHHH		23.2319823750
783PhosphorylationRPSYMPSSASYAASD
CCCCCCCCHHHHHHC		18.5019823750
785PhosphorylationSYMPSSASYAASDFV
CCCCCCHHHHHHCCC		19.7719823750
786PhosphorylationYMPSSASYAASDFVP
CCCCCHHHHHHCCCC		13.1019823750
789PhosphorylationSSASYAASDFVPAAV
CCHHHHHHCCCCCEE		24.3319823750
797PhosphorylationDFVPAAVTANATIPS
CCCCCEECCCCCCCC		14.9619823750
801PhosphorylationAAVTANATIPSLDSS
CEECCCCCCCCCCCC		32.9819823750
804PhosphorylationTANATIPSLDSSSEA
CCCCCCCCCCCCCHH		40.7419823750
807PhosphorylationATIPSLDSSSEASRE
CCCCCCCCCCHHHHH		40.8519823750
808PhosphorylationTIPSLDSSSEASREA
CCCCCCCCCHHHHHC		31.6819823750
809PhosphorylationIPSLDSSSEASREAS
CCCCCCCCHHHHHCC		40.9319823750
812PhosphorylationLDSSSEASREASPAP
CCCCCHHHHHCCCCC		26.9719823750
816PhosphorylationSEASREASPAPTGSH
CHHHHHCCCCCCCCC		19.4922369663
820PhosphorylationREASPAPTGSHSLTK
HHCCCCCCCCCCCCC		54.1222369663
822PhosphorylationASPAPTGSHSLTKGM
CCCCCCCCCCCCCCC		16.6322369663
824PhosphorylationPAPTGSHSLTKGMAE
CCCCCCCCCCCCCCE		39.1622369663
826PhosphorylationPTGSHSLTKGMAELN
CCCCCCCCCCCCEEC		28.6822369663
827AcetylationTGSHSLTKGMAELNV
CCCCCCCCCCCEECC		52.5624489116
837PhosphorylationAELNVQESKVEVPEV
CEECCCCCCEECCCC		25.5522369663
838AcetylationELNVQESKVEVPEVP
EECCCCCCEECCCCC		41.4824489116
849AcetylationPEVPAPTKNEEKAAP
CCCCCCCCCCCCCCC		62.3924489116
849UbiquitinationPEVPAPTKNEEKAAP
CCCCCCCCCCCCCCC		62.3923749301
853UbiquitinationAPTKNEEKAAPIVDD
CCCCCCCCCCCCCCC		43.6023749301
863PhosphorylationPIVDDEETEFDIYNS
CCCCCCCCEEEEECC		39.6524961812
868PhosphorylationEETEFDIYNSKVIAC
CCCEEEEECCEEEEE		18.4124961812
870PhosphorylationTEFDIYNSKVIACAI
CEEEEECCEEEEEEE		16.0128152593
871UbiquitinationEFDIYNSKVIACAID
EEEEECCEEEEEEEC		33.7415699485
887PhosphorylationPEACEMCSG------
HHHHHHCCC------		46.3425521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SML1_YEASTSML1physical
9774971
SML1_YEASTSML1physical
11904430
SML1_YEASTSML1physical
11074005
RIR1_YEASTRNR1physical
9774971
RIR1_YEASTRNR1physical
10593972
RIR1_YEASTRNR1physical
11893751
RFX1_YEASTRFX1genetic
9741624
RIR3_YEASTRNR3genetic
2199320
HSP26_YEASTHSP26physical
16554755
RIR3_YEASTRNR3physical
16554755
RIR2_YEASTRNR2physical
16554755
RIR2_YEASTRNR2physical
16537480
RIR4_YEASTRNR4physical
16537480
ORC2_YEASTORC2genetic
17227840
ORC5_YEASTORC5genetic
17227840
DUN1_YEASTDUN1genetic
20215435
RFX1_YEASTRFX1genetic
20219942
URA7_YEASTURA7genetic
20219942
FOLE_YEASTMET7genetic
20219942
RRM3_YEASTRRM3genetic
20219942
FEN1_YEASTRAD27genetic
20219942
MRC1_YEASTMRC1genetic
20219942
CGS5_YEASTCLB5genetic
20219942
DPB4_YEASTDPB4genetic
20219942
DPB3_YEASTDPB3genetic
20219942
NAGS_YEASTARG2genetic
20219942
GLN3_YEASTGLN3genetic
20219942
RIR2_YEASTRNR2physical
20516199
HDA1_YEASTHDA1genetic
21288874
SML1_YEASTSML1genetic
20566477
DUN1_YEASTDUN1genetic
20566477
FOLE_YEASTMET7physical
24728996
PMP1_YEASTPMP1physical
26404137
MSH2_YEASTMSH2genetic
25474551
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIR1_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227; SER-809; SER-812;SER-816; SER-837 AND SER-887, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-816, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-816, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory