dbPTM

STN1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STN1_YEAST
UniProt AC	P38960
Protein Name	Protein STN1
Gene Name	STN1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	494
Subcellular Localization	Chromosome, telomere .
Protein Description	Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13..
Protein Sequence	MDKYGHIAHQEGDVCYYIPRLFKYNSYYSGTEDVRIFVGDLKYRMRVSLQICEKYYDRRLSMLFWKNHPLQQIHLIGCIIGLQFKWIGKQEYIFFQLDDCTSDSSLVGYTSDMRFLTCKVKKDSILSWGLNITDLIGLTLHVYGQASLNYQELQVEYLRLCYSLTEEIDHWKITMNMREQLDTPWSLSDFVIGELFTQEQEWTPETSQIEVVNPDFVGIGYKTPESKRNETTFIEQLQEERLKDELEIISPYNSTDTSNSVHSLSFRFVSSLKDFPETHFLNSGDQIDNGNDEQLKKLEYQSANLPVMIPNRTSAKSNLMLILLGLQMKEISNSDLYKLKEVRSVVTSLASFLFQQQNVGVMKSFDSLEKEAFRDLVNRLVSQGLIGLKDKTSETFDLLPLKNLFEYAEKRISVLMKLQCYTGTVQLSHVQEKLHLPYITTNGIVDVFKECLKRTKKQYPEVLKNWWIDLDPKNGMEDQNSGILLHLEYAAAYS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
283	Phosphorylation	PETHFLNSGDQIDNG CCCCCCCCCCCCCCC	45.99	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STN1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STN1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STN1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TEN1_YEAST	TEN1	physical	11230140
CDC13_YEAST	CDC13	physical	11230140
CDC13_YEAST	CDC13	physical	11370858
CDC13_YEAST	CDC13	physical	9042864
HSC82_YEAST	HSC82	genetic	11370858
TEN1_YEAST	TEN1	genetic	11230140
CDC13_YEAST	CDC13	genetic	9042864
DPOA2_YEAST	POL12	genetic	15132993
CDC13_YEAST	CDC13	physical	16767082
TEN1_YEAST	TEN1	physical	16767082
DPOA2_YEAST	POL12	physical	16767082
TEN1_YEAST	TEN1	physical	17293872
CDC13_YEAST	CDC13	physical	17166094
CDC13_YEAST	CDC13	physical	17947422
TEN1_YEAST	TEN1	physical	17947422
RAD52_YEAST	RAD52	genetic	17947422
TERT_YEAST	EST2	genetic	17947422
RAD9_YEAST	RAD9	genetic	17947422
RAD24_YEAST	RAD24	genetic	17947422
TGS1_YEAST	TGS1	genetic	18840651
DPOA2_YEAST	POL12	genetic	19171895
TERT_YEAST	EST2	genetic	19172739
ATM_YEAST	TEL1	genetic	19172739
RAD50_YEAST	RAD50	genetic	19172739
TEN1_YEAST	TEN1	physical	20157006
TEN1_YEAST	TEN1	genetic	20157006
STM1_YEAST	STM1	genetic	21399640
RIF1_YEAST	RIF1	genetic	21437267
CDC13_YEAST	CDC13	physical	21743457
RAD24_YEAST	RAD24	genetic	22377634
RAD50_YEAST	RAD50	genetic	22645309
RAD51_YEAST	RAD51	genetic	22645309
CDC13_YEAST	CDC13	physical	23177925
CDC13_YEAST	CDC13	genetic	24164896
EXO1_YEAST	EXO1	genetic	24164896
TEN1_YEAST	TEN1	genetic	24039592
PSB3_YEAST	PUP3	genetic	27708008
PSA1_YEAST	SCL1	genetic	27708008
GPI10_YEAST	GPI10	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
NMT_YEAST	NMT1	genetic	27708008
GPI15_YEAST	GPI15	genetic	27708008
NAB3_YEAST	NAB3	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008
CSK2B_YEAST	CKB1	genetic	27708008
XRN1_YEAST	XRN1	genetic	27708008
RMR1_YEAST	RMR1	genetic	27708008
UPF3_YEAST	UPF3	genetic	27708008
PSA3_YEAST	PRE9	genetic	27708008
LSM1_YEAST	LSM1	genetic	27708008
CTK1_YEAST	CTK1	genetic	27708008
NAM7_YEAST	NAM7	genetic	27708008
PFD4_YEAST	GIM3	genetic	27708008
EXO1_YEAST	EXO1	genetic	27708008
KPYK1_YEAST	CDC19	genetic	27708008
DPOA2_YEAST	POL12	genetic	27708008
CND2_YEAST	BRN1	genetic	27708008
ORC2_YEAST	ORC2	genetic	27708008
CDK1_YEAST	CDC28	genetic	27708008
MED8_YEAST	MED8	genetic	27708008
GLE1_YEAST	GLE1	genetic	27708008
CDC13_YEAST	CDC13	genetic	27708008
UTP5_YEAST	UTP5	genetic	27708008
UTP6_YEAST	UTP6	genetic	27708008
RNA15_YEAST	RNA15	genetic	27708008
HSF_YEAST	HSF1	genetic	27708008
SLD3_YEAST	SLD3	genetic	27708008
MCE1_YEAST	CEG1	genetic	27708008
SYV_YEAST	VAS1	genetic	27708008
ESP1_YEAST	ESP1	genetic	27708008
MPPA_YEAST	MAS2	genetic	27708008
DNA2_YEAST	DNA2	genetic	27708008
UTP9_YEAST	UTP9	genetic	27708008
PAN1_YEAST	PAN1	genetic	27708008
PRI1_YEAST	PRI1	genetic	27708008
STS1_YEAST	STS1	genetic	27708008
PSF2_YEAST	PSF2	genetic	27708008
CDC6_YEAST	CDC6	genetic	27708008
DPOD2_YEAST	POL31	genetic	27708008
NUP85_YEAST	NUP85	genetic	27708008
RFC2_YEAST	RFC2	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
PRI2_YEAST	PRI2	genetic	27708008
NOC3_YEAST	NOC3	genetic	27708008
SMC4_YEAST	SMC4	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
ORC1_YEAST	ORC1	genetic	27708008
UTP15_YEAST	UTP15	genetic	27708008
DPOA_YEAST	POL1	genetic	27708008
MVD1_YEAST	MVD1	genetic	27708008
RFC4_YEAST	RFC4	genetic	27708008
MED4_YEAST	MED4	genetic	27708008
LAS17_YEAST	LAS17	genetic	27708008
RPAB3_YEAST	RPB8	genetic	27708008
RPA1_YEAST	RPA190	genetic	27708008
TF2B_YEAST	SUA7	genetic	27708008
ORC4_YEAST	ORC4	genetic	27708008
VPS8_YEAST	VPS8	genetic	27708008
URA7_YEAST	URA7	genetic	27708008
PIN4_YEAST	PIN4	genetic	27708008
HSP73_YEAST	SSA3	genetic	27708008
FAT1_YEAST	FAT1	genetic	27708008
NPL4_YEAST	NPL4	genetic	27708008
CHK1_YEAST	CHK1	genetic	27708008
RIF1_YEAST	RIF1	genetic	27708008
MRC1_YEAST	MRC1	genetic	27708008
NAA38_YEAST	MAK31	genetic	27708008
DTD_YEAST	DTD1	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
DOT1_YEAST	DOT1	genetic	27708008
RAD4_YEAST	RAD4	genetic	27708008
RAD24_YEAST	RAD24	genetic	27708008
YFF1_YEAST	YFL051C	genetic	27708008
SA155_YEAST	SAP155	genetic	27708008
ERJ5_YEAST	ERJ5	genetic	27708008
DUG1_YEAST	DUG1	genetic	27708008
KXD1_YEAST	KXD1	genetic	27708008
HUR1_YEAST	HUR1	genetic	27708008
YGS6_YEAST	YGL176C	genetic	27708008
ATG1_YEAST	ATG1	genetic	27708008
MTC3_YEAST	MTC3	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
BUD9_YEAST	BUD9	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
CHO2_YEAST	CHO2	genetic	27708008
RPN10_YEAST	RPN10	genetic	27708008
RPA34_YEAST	RPA34	genetic	27708008
DPOD3_YEAST	POL32	genetic	27708008
YKH7_YEAST	YKL077W	genetic	27708008
HS104_YEAST	HSP104	genetic	27708008
UBR2_YEAST	UBR2	genetic	27708008
APTH1_YEAST	YLR118C	genetic	27708008
UPS1_YEAST	UPS1	genetic	27708008
COA4_YEAST	COA4	genetic	27708008
FKS1_YEAST	FKS1	genetic	27708008
RS3A1_YEAST	RPS1A	genetic	27708008
CSM3_YEAST	CSM3	genetic	27708008
MUB1_YEAST	MUB1	genetic	27708008
MLH1_YEAST	MLH1	genetic	27708008
OCA2_YEAST	OCA2	genetic	27708008
MAS5_YEAST	YDJ1	genetic	27708008
NST1_YEAST	NST1	genetic	27708008
RRP6_YEAST	RRP6	genetic	27708008
BUB3_YEAST	BUB3	genetic	27708008
BUD21_YEAST	BUD21	genetic	27708008
LGE1_YEAST	LGE1	genetic	27708008
RL21B_YEAST	RPL21B	genetic	27708008
PTPA2_YEAST	RRD2	genetic	27708008
NIP80_YEAST	NIP100	genetic	27708008
NAA30_YEAST	MAK3	genetic	27708008
YPR71_YEAST	YPR071W	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STN1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, AND MASSSPECTROMETRY.	18407956 [Abstract]