| UniProt ID | HSF_YEAST | |
|---|---|---|
| UniProt AC | P10961 | |
| Protein Name | Heat shock factor protein | |
| Gene Name | HSF1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 833 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. Also required for growth at normal temperatures.. | |
| Protein Sequence | MNNAANTGTTNESNVSDAPRIEPLPSLNDDDIEKILQPNDIFTTDRTDASTTSSTAIEDIINPSLDPQSAASPVPSSSFFHDSRKPSTSTHLVRRGTPLGIYQTNLYGHNSRENTNPNSTLLSSKLLAHPPVPYGQNPDLLQHAVYRAQPSSGTTNAQPRQTTRRYQSHKSRPAFVNKLWSMLNDDSNTKLIQWAEDGKSFIVTNREEFVHQILPKYFKHSNFASFVRQLNMYGWHKVQDVKSGSIQSSSDDKWQFENENFIRGREDLLEKIIRQKGSSNNHNSPSGNGNPANGSNIPLDNAAGSNNSNNNISSSNSFFNNGHLLQGKTLRLMNEANLGDKNDVTAILGELEQIKYNQIAISKDLLRINKDNELLWQENMMARERHRTQQQALEKMFRFLTSIVPHLDPKMIMDGLGDPKVNNEKLNSANNIGLNRDNTGTIDELKSNDSFINDDRNSFTNATTNARNNMSPNNDDNSIDTASTNTTNRKKNIDENIKNNNDIINDIIFNTNLANNLSNYNSNNNAGSPIRPYKQRYLLKNRANSSTSSENPSLTPFDIESNNDRKISEIPFDDEEEEETDFRPFTSRDPNNQTSENTFDPNRFTMLSDDDLKKDSHTNDNKHNESDLFWDNVHRNIDEQDARLQNLENMVHILSPGYPNKSFNNKTSSTNTNSNMESAVNVNSPGFNLQDYLTGESNSPNSVHSVPSNGSGSTPLPMPNDNDTEHASTSVNQGENGSGLTPFLTVDDHTLNDNNTSEGSTRVSPDIKFSATENTKVSDNLPSFNDHSYSTQADTAPENAKKRFVEEIPEPAIVEIQDPTEYNDHRLPKRAKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MNNAANTG -------CCCCCCCC | 8.66 | 22814378 | |
| 26 | Phosphorylation | PRIEPLPSLNDDDIE CCCCCCCCCCHHHHH | 47.70 | 28889911 | |
| 72 | Phosphorylation | LDPQSAASPVPSSSF CCHHHCCCCCCCHHH | 26.58 | 28889911 | |
| 78 | Phosphorylation | ASPVPSSSFFHDSRK CCCCCCHHHCCCCCC | 35.95 | 27017623 | |
| 87 | Phosphorylation | FHDSRKPSTSTHLVR CCCCCCCCCCCCCHH | 37.72 | 19779198 | |
| 90 | Phosphorylation | SRKPSTSTHLVRRGT CCCCCCCCCCHHCCC | 21.22 | 21551504 | |
| 97 | Phosphorylation | THLVRRGTPLGIYQT CCCHHCCCCCEEEEC | 17.33 | 22369663 | |
| 111 | Phosphorylation | TNLYGHNSRENTNPN CCCCCCCCCCCCCCC | 34.98 | 28889911 | |
| 115 | Phosphorylation | GHNSRENTNPNSTLL CCCCCCCCCCCCCCC | 47.50 | 28889911 | |
| 219 | Acetylation | QILPKYFKHSNFASF HHHHHHHCCCCHHHH | 42.93 | 24489116 | |
| 243 | Phosphorylation | HKVQDVKSGSIQSSS EECEECCCCCCCCCC | 37.31 | 28889911 | |
| 363 | Ubiquitination | YNQIAISKDLLRINK HHEEEECHHHHHHCC | 46.40 | 24961812 | |
| 395 | Ubiquitination | TQQQALEKMFRFLTS HHHHHHHHHHHHHHH | 44.16 | 17644757 | |
| 410 | Ubiquitination | IVPHLDPKMIMDGLG HHCCCCHHHHHCCCC | 40.50 | 17644757 | |
| 428 | Phosphorylation | VNNEKLNSANNIGLN CCHHHCCCCCCCCCC | 42.69 | 30377154 | |
| 439 | Phosphorylation | IGLNRDNTGTIDELK CCCCCCCCCCHHHHH | 39.74 | 25752575 | |
| 447 | Phosphorylation | GTIDELKSNDSFIND CCHHHHHHCCCCCCC | 59.50 | 21551504 | |
| 450 | Phosphorylation | DELKSNDSFINDDRN HHHHHCCCCCCCCCC | 32.07 | 22369663 | |
| 458 | Phosphorylation | FINDDRNSFTNATTN CCCCCCCCHHHHCCC | 34.05 | 22369663 | |
| 460 | Phosphorylation | NDDRNSFTNATTNAR CCCCCCHHHHCCCCC | 24.62 | 22369663 | |
| 463 | Phosphorylation | RNSFTNATTNARNNM CCCHHHHCCCCCCCC | 23.74 | 22369663 | |
| 464 | Phosphorylation | NSFTNATTNARNNMS CCHHHHCCCCCCCCC | 25.19 | 21551504 | |
| 471 | Phosphorylation | TNARNNMSPNNDDNS CCCCCCCCCCCCCCC | 26.97 | 22369663 | |
| 478 | Phosphorylation | SPNNDDNSIDTASTN CCCCCCCCCCCCCCC | 28.92 | 22369663 | |
| 481 | Phosphorylation | NDDNSIDTASTNTTN CCCCCCCCCCCCCCC | 22.34 | 22369663 | |
| 483 | Phosphorylation | DNSIDTASTNTTNRK CCCCCCCCCCCCCHH | 25.04 | 22369663 | |
| 484 | Phosphorylation | NSIDTASTNTTNRKK CCCCCCCCCCCCHHH | 33.83 | 21440633 | |
| 486 | Phosphorylation | IDTASTNTTNRKKNI CCCCCCCCCCHHHCC | 26.07 | 22369663 | |
| 487 | Phosphorylation | DTASTNTTNRKKNID CCCCCCCCCHHHCCC | 34.79 | 22369663 | |
| 511 | Phosphorylation | INDIIFNTNLANNLS HHHHHCCCCCCCCCC | 22.36 | 22369663 | |
| 518 | Phosphorylation | TNLANNLSNYNSNNN CCCCCCCCCCCCCCC | 39.12 | 22369663 | |
| 520 | Phosphorylation | LANNLSNYNSNNNAG CCCCCCCCCCCCCCC | 19.32 | 22369663 | |
| 522 | Phosphorylation | NNLSNYNSNNNAGSP CCCCCCCCCCCCCCC | 30.49 | 19779198 | |
| 528 | Phosphorylation | NSNNNAGSPIRPYKQ CCCCCCCCCCCCHHH | 18.10 | 22369663 | |
| 533 | Phosphorylation | AGSPIRPYKQRYLLK CCCCCCCHHHHHHHH | 15.20 | 22369663 | |
| 545 | Phosphorylation | LLKNRANSSTSSENP HHHCCCCCCCCCCCC | 33.73 | 22369663 | |
| 546 | Phosphorylation | LKNRANSSTSSENPS HHCCCCCCCCCCCCC | 31.92 | 22369663 | |
| 547 | Phosphorylation | KNRANSSTSSENPSL HCCCCCCCCCCCCCC | 35.77 | 22369663 | |
| 548 | Phosphorylation | NRANSSTSSENPSLT CCCCCCCCCCCCCCC | 37.29 | 20377248 | |
| 549 | Phosphorylation | RANSSTSSENPSLTP CCCCCCCCCCCCCCC | 41.29 | 20377248 | |
| 553 | Phosphorylation | STSSENPSLTPFDIE CCCCCCCCCCCCCCC | 57.36 | 22369663 | |
| 555 | Phosphorylation | SSENPSLTPFDIESN CCCCCCCCCCCCCCC | 26.67 | 22369663 | |
| 561 | Phosphorylation | LTPFDIESNNDRKIS CCCCCCCCCCCCEEE | 41.07 | 22369663 | |
| 608 | Phosphorylation | PNRFTMLSDDDLKKD CCCCEECCHHHHCCC | 28.33 | 22369663 | |
| 655 | Phosphorylation | ENMVHILSPGYPNKS HHHHHHHCCCCCCCC | 18.71 | 22369663 | |
| 658 | Phosphorylation | VHILSPGYPNKSFNN HHHHCCCCCCCCCCC | 13.66 | 28132839 | |
| 662 | Phosphorylation | SPGYPNKSFNNKTSS CCCCCCCCCCCCCCC | 39.59 | 25752575 | |
| 783 | Phosphorylation | KVSDNLPSFNDHSYS CCCCCCCCCCCCCCC | 39.59 | 28889911 | |
| 788 | Phosphorylation | LPSFNDHSYSTQADT CCCCCCCCCCCCCCC | 24.52 | 23749301 | |
| 791 | Phosphorylation | FNDHSYSTQADTAPE CCCCCCCCCCCCCCH | 21.39 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HSF_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HSF_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HSF_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-72; THR-439;SER-450; SER-458; SER-545; SER-608; SER-662 AND SER-783, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450; THR-460 ANDSER-546, AND MASS SPECTROMETRY. | |
