| UniProt ID | RQC2_YEAST | |
|---|---|---|
| UniProt AC | Q12532 | |
| Protein Name | Ribosome quality control complex subunit 2 {ECO:0000303|PubMed:25554787} | |
| Gene Name | RQC2 {ECO:0000303|PubMed:25554787} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1038 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. [PubMed: 23178123 RQC2 is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety] | |
| Protein Sequence | MKQRISALDLLLLARELKQDLEGYRLSNIYNIADSSKQFLLKFNKPDSKLNVVVDCGLRIYLTEFSRPIPPTPSGFVVKLRKHLKAKRLTALKQVDQDRILVLQFADGHFYLVLEFFSAGNVILLDENRRIMALQRVVLEHENKVGQIYEMFDESLFTTNNESADESIEKNRKAEYTSELVNEWIKAVQAKYESDITVIKQLNIQGKEGAKKKKVKVPSIHKLLLSKVPHLSSDLLSKNLKVFNIDPSESCLNLLEETDSLAELLNSTQLEYNQLLTTTDRKGYILAKRNENYISEKDTADLEFIYDTFHPFKPYINGGDTDSSCIIEVEGPYNRTLDKFFSTIESSKYALRIQNQESQAQKKIDDARAENDRKIQALLDVQELNERKGHLIIENAPLIEEVKLAVQGLIDQQMDWNTIEKLIKSEQKKGNRIAQLLNLPLNLKQNKISVKLDLSSKELNTSSDEDNESEGNTTDSSSDSDSEDMESSKERSTKSMKRKSNEKINVTIDLGLSAYANATEYFNIKKTSAQKQKKVEKNVGKAMKNIEVKIDQQLKKKLKDSHSVLKKIRTPYFFEKYSWFISSEGFLVMMGKSPAETDQIYSKYIEDDDIYMSNSFNSHVWIKNPEKTEVPPNTLMQAGILCMSSSEAWSKKISSSPWWCFAKNVSKFDGSDNSILPEGAFRLKNENDQNHLPPAQLVMGFGFLWKVKTSGNEDNGDDDEEEEEEEEEEEEEEEEEEEEEEEEKEEEEKEEEQQQDEDDSNEVNGLEKGGDSNDSTKNNSFEHDNLEKDIEKHCTISSDTDSDSGNAKAKNDNSSTQRILDEPGVPISLIENINSNVRGKRGKLKKIQKKYADQDETERLLRLEALGTLKGIEKQQQRKKEEIMKREVREDRKNKREKQRRLQALKFTKKEKARVNYDKHKSELKPSLDKGDVVDDIIPVFAPWPALLKYKYKVKIQPGSAKKTKTLTEILHYFKSRPLDGSSTDNEMDWPQEHEMIKGLKEQDLVLLLCVDKLKVTIAGQKSTKNGGNSSKKGKKKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Ubiquitination | KQRISALDLLLLARE HHHHHHHHHHHHHHH | PubMed | ||
| 37 | Acetylation | YNIADSSKQFLLKFN EECCCCCCEEHHHHC | 24489116 | ||
| 42 | Acetylation | SSKQFLLKFNKPDSK CCCEEHHHHCCCCCC | 24489116 | ||
| 339 | Acetylation | PYNRTLDKFFSTIES CCCCCHHHHHHHHHH | 24489116 | ||
| 544 | Acetylation | KNVGKAMKNIEVKID HHHHHHHHHCHHHHH | 25381059 | ||
| 561 | Phosphorylation | LKKKLKDSHSVLKKI HHHHCCCCHHHHHHC | 19779198 | ||
| 563 | Phosphorylation | KKLKDSHSVLKKIRT HHCCCCHHHHHHCCC | 28889911 | ||
| 570 | Phosphorylation | SVLKKIRTPYFFEKY HHHHHCCCCHHHHHE | 21440633 | ||
| 628 | Phosphorylation | WIKNPEKTEVPPNTL EECCCCCCCCCCCCH | 23749301 | ||
| 634 | Phosphorylation | KTEVPPNTLMQAGIL CCCCCCCCHHHCCEE | 23749301 | ||
| 644 | Phosphorylation | QAGILCMSSSEAWSK HCCEEEECCCHHHHC | 23749301 | ||
| 645 | Phosphorylation | AGILCMSSSEAWSKK CCEEEECCCHHHHCH | 23749301 | ||
| 646 | Phosphorylation | GILCMSSSEAWSKKI CEEEECCCHHHHCHH | 23749301 | ||
| 760 | Phosphorylation | QQQDEDDSNEVNGLE HHHCCCCCCCCCCCC | 28889911 | ||
| 772 | Phosphorylation | GLEKGGDSNDSTKNN CCCCCCCCCCCCCCC | 29136822 | ||
| 775 | Phosphorylation | KGGDSNDSTKNNSFE CCCCCCCCCCCCCCC | 29136822 | ||
| 776 | Phosphorylation | GGDSNDSTKNNSFEH CCCCCCCCCCCCCCC | 19779198 | ||
| 777 | Acetylation | GDSNDSTKNNSFEHD CCCCCCCCCCCCCCC | 24489116 | ||
| 780 | Phosphorylation | NDSTKNNSFEHDNLE CCCCCCCCCCCCCHH | 22369663 | ||
| 788 | Acetylation | FEHDNLEKDIEKHCT CCCCCHHHHHHHHCE | 24489116 | ||
| 795 | Phosphorylation | KDIEKHCTISSDTDS HHHHHHCEECCCCCC | 22890988 | ||
| 797 | Phosphorylation | IEKHCTISSDTDSDS HHHHCEECCCCCCCC | 19823750 | ||
| 798 | Phosphorylation | EKHCTISSDTDSDSG HHHCEECCCCCCCCC | 19823750 | ||
| 800 | Phosphorylation | HCTISSDTDSDSGNA HCEECCCCCCCCCCC | 19823750 | ||
| 802 | Phosphorylation | TISSDTDSDSGNAKA EECCCCCCCCCCCCC | 19823750 | ||
| 804 | Phosphorylation | SSDTDSDSGNAKAKN CCCCCCCCCCCCCCC | 22890988 | ||
| 815 | Phosphorylation | KAKNDNSSTQRILDE CCCCCCHHHHHHHCC | 27214570 | ||
| 816 | Phosphorylation | AKNDNSSTQRILDEP CCCCCHHHHHHHCCC | 27017623 | ||
| 850 | Acetylation | KLKKIQKKYADQDET CHHHHHHHHCCHHHH | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RQC2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RQC2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RQC2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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