| UniProt ID | RQC1_YEAST | |
|---|---|---|
| UniProt AC | Q05468 | |
| Protein Name | Ribosome quality control complex subunit 1 {ECO:0000303|PubMed:23178123} | |
| Gene Name | RQC1 {ECO:0000303|PubMed:23178123} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 723 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. [PubMed: 23178123 RQC1 is essential for the recruitment of CDC48 to ribosomal subunits] | |
| Protein Sequence | MSSRALRRLQDDNALLESLLSNSNANKMTSGKSTAGNIQKRENIFSMMNNVRDSDNSTDEGQMSEQDEEAAAAGERDTQSNGQPKRITLASKSSRRKKNKKAKRKQKNHTAEAAKDKGSDDDDDDEEFDKIIQQFKKTDILKYGKTKNDDTNEEGFFTASEPEEASSQPWKSFLSLESDPGFTKFPISCLRHSCKFFQNDFKKLDPHTEFKLLFDDISPESLEDIDSMTSTPVSPQQLKQIQRLKRLIRNWGGKDHRLAPNGPGMHPQHLKFTKIRDDWIPTQRGELSMKLLSSDDLLDWQLWERPLDWKDVIQNDVSQWQKFISFYKFEPLNSDLSKKSMMDFYLSVIVHPDHEALINLISSKFPYHVPGLLQVALIFIRQGDRSNTNGLLQRALFVFDRALKANIIFDSLNCQLPYIYFFNRQFYLAIFRYIQSLAQRGVIGTASEWTKVLWSLSPLEDPLGCRYFLDHYFLLNNDYQYIIELSNSPLMNCYKQWNTLGFSLAVVLSFLRINEMSSARNALLKAFKHHPLQLSELFKEKLLGDHALTKDLSIDGHSAENLELKAYMARFPLLWNRNEEVTFLHDEMSSILQDYHRGNVTIDSNDGQDHNNINNLQSPFFIAGIPINLLRFAILSEESSVMAAIPSFIWSDNEVYEFDVLPPMPTSKESIEVVENIKTFINEKDLAVLQAERMQDEDLLNQIRQISLQQYIHENEESNENEG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSRALRRL ------CCHHHHHHH | 24961812 | ||
| 3 | Phosphorylation | -----MSSRALRRLQ -----CCHHHHHHHH | 24961812 | ||
| 54 | Phosphorylation | MMNNVRDSDNSTDEG HHHCCCCCCCCCCCC | 19795423 | ||
| 57 | Phosphorylation | NVRDSDNSTDEGQMS CCCCCCCCCCCCCCC | 19795423 | ||
| 58 | Phosphorylation | VRDSDNSTDEGQMSE CCCCCCCCCCCCCCH | 19795423 | ||
| 64 | Phosphorylation | STDEGQMSEQDEEAA CCCCCCCCHHHHHHH | 23749301 | ||
| 119 | Phosphorylation | EAAKDKGSDDDDDDE HHHHHCCCCCCCCHH | 25521595 | ||
| 143 | Phosphorylation | KKTDILKYGKTKNDD HHCCHHHCCCCCCCC | 27017623 | ||
| 146 | Phosphorylation | DILKYGKTKNDDTNE CHHHCCCCCCCCCCC | 27017623 | ||
| 151 | Phosphorylation | GKTKNDDTNEEGFFT CCCCCCCCCCCCCCC | 28889911 | ||
| 158 | Phosphorylation | TNEEGFFTASEPEEA CCCCCCCCCCCCHHH | 22369663 | ||
| 160 | Phosphorylation | EEGFFTASEPEEASS CCCCCCCCCCHHHCC | 22369663 | ||
| 166 | Phosphorylation | ASEPEEASSQPWKSF CCCCHHHCCCCCHHH | 19779198 | ||
| 167 | Phosphorylation | SEPEEASSQPWKSFL CCCHHHCCCCCHHHH | 27017623 | ||
| 172 | Phosphorylation | ASSQPWKSFLSLESD HCCCCCHHHHCCCCC | 21551504 | ||
| 218 | Phosphorylation | KLLFDDISPESLEDI EEEECCCCHHHHHHH | 19779198 | ||
| 229 | Phosphorylation | LEDIDSMTSTPVSPQ HHHHHHCCCCCCCHH | 19779198 | ||
| 230 | Phosphorylation | EDIDSMTSTPVSPQQ HHHHHCCCCCCCHHH | 24961812 | ||
| 231 | Phosphorylation | DIDSMTSTPVSPQQL HHHHCCCCCCCHHHH | 24961812 | ||
| 234 | Phosphorylation | SMTSTPVSPQQLKQI HCCCCCCCHHHHHHH | 21440633 | ||
| 472 | Phosphorylation | CRYFLDHYFLLNNDY HHHHHHEEEECCCCE | 19779198 | ||
| 558 | Phosphorylation | DLSIDGHSAENLELK CCCCCCCCHHHHHHH | 21440633 | ||
| 684 | Acetylation | IKTFINEKDLAVLQA HHHHCCHHHHHHHHH | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RQC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RQC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RQC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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