GLYC_YEAST - dbPTM
GLYC_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLYC_YEAST
UniProt AC P37291
Protein Name Serine hydroxymethyltransferase, cytosolic
Gene Name SHM2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 469
Subcellular Localization Cytoplasm.
Protein Description Interconversion of serine and glycine..
Protein Sequence MPYTLSDAHHKLITSHLVDTDPEVDSIIKDEIERQKHSIDLIASENFTSTSVFDALGTPLSNKYSEGYPGARYYGGNEHIDRMEILCQQRALKAFHVTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLYLPDGGHLSHGYATENRKISAVSTYFESFPYRVNPETGIIDYDTLEKNAILYRPKVLVAGTSAYCRLIDYKRMREIADKCGAYLMVDMAHISGLIAAGVIPSPFEYADIVTTTTHKSLRGPRGAMIFFRRGVRSINPKTGKEVLYDLENPINFSVFPGHQGGPHNHTIAALATALKQAATPEFKEYQTQVLKNAKALESEFKNLGYRLVSNGTDSHMVLVSLREKGVDGARVEYICEKINIALNKNSIPGDKSALVPGGVRIGAPAMTTRGMGEEDFHRIVQYINKAVEFAQQVQQSLPKDACRLKDFKAKVDEGSDVLNTWKKEIYDWAGEYPLAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MPYTLSDAHHK
----CCCCCHHHCHH		17.5728889911
14PhosphorylationDAHHKLITSHLVDTD
HHCHHHHHHCCCCCC		22.1121440633
15PhosphorylationAHHKLITSHLVDTDP
HCHHHHHHCCCCCCH		14.0822369663
20PhosphorylationITSHLVDTDPEVDSI
HHHCCCCCCHHHHHH		46.0722369663
26PhosphorylationDTDPEVDSIIKDEIE
CCCHHHHHHHHHHHH		31.2422369663
29AcetylationPEVDSIIKDEIERQK
HHHHHHHHHHHHHHH		47.8724489116
29SuccinylationPEVDSIIKDEIERQK
HHHHHHHHHHHHHHH		47.8723954790
29UbiquitinationPEVDSIIKDEIERQK
HHHHHHHHHHHHHHH		47.8722817900
44PhosphorylationHSIDLIASENFTSTS
CCEEEEECCCCCCCC		26.5327017623
48PhosphorylationLIASENFTSTSVFDA
EEECCCCCCCCHHHC		42.5527017623
49PhosphorylationIASENFTSTSVFDAL
EECCCCCCCCHHHCC		17.9727017623
50PhosphorylationASENFTSTSVFDALG
ECCCCCCCCHHHCCC		26.3327017623
61PhosphorylationDALGTPLSNKYSEGY
HCCCCCCCCCCCCCC		32.2627017623
93AcetylationLCQQRALKAFHVTPD
HHHHHHHHHHCCCCC		48.2824489116
101AcetylationAFHVTPDKWGVNVQT
HHCCCCCCCCEEEEE		47.2324489116
124AcetylationQVYQAIMKPHERLMG
HHHHHHCCHHHHHCC		36.7924489116
150UbiquitinationGYATENRKISAVSTY
CEECCCCCCCEEEEH		53.2324961812
152PhosphorylationATENRKISAVSTYFE
ECCCCCCCEEEEHHH		26.1728889911
155PhosphorylationNRKISAVSTYFESFP
CCCCCEEEEHHHCCC		19.6721440633
156PhosphorylationRKISAVSTYFESFPY
CCCCEEEEHHHCCCC		26.1528889911
179AcetylationIDYDTLEKNAILYRP
CCHHHHCCCEEEECC		55.5824489116
179UbiquitinationIDYDTLEKNAILYRP
CCHHHHCCCEEEECC		55.5823749301
187UbiquitinationNAILYRPKVLVAGTS
CEEEECCEEEEECCH		38.9223749301
187AcetylationNAILYRPKVLVAGTS
CEEEECCEEEEECCH		38.9224489116
193PhosphorylationPKVLVAGTSAYCRLI
CEEEEECCHHHHHHH		10.6330377154
194PhosphorylationKVLVAGTSAYCRLID
EEEEECCHHHHHHHC		19.1421440633
203AcetylationYCRLIDYKRMREIAD
HHHHHCHHHHHHHHH		35.6522865919
248OtherIVTTTTHKSLRGPRG
EEEECCCHHHCCCCC		49.44-
248N6-(pyridoxal phosphate)lysineIVTTTTHKSLRGPRG
EEEECCCHHHCCCCC		49.44-
273AcetylationSINPKTGKEVLYDLE
CCCCCCCCCEEEECC		50.2924489116
316SuccinylationQAATPEFKEYQTQVL
HHCCHHHHHHHHHHH		54.5823954790
316AcetylationQAATPEFKEYQTQVL
HHCCHHHHHHHHHHH		54.5824489116
316UbiquitinationQAATPEFKEYQTQVL
HHCCHHHHHHHHHHH		54.5823749301
324SuccinylationEYQTQVLKNAKALES
HHHHHHHHHHHHHHH		56.8823954790
324AcetylationEYQTQVLKNAKALES
HHHHHHHHHHHHHHH		56.8822865919
327SuccinylationTQVLKNAKALESEFK
HHHHHHHHHHHHHHH		64.0023954790
331PhosphorylationKNAKALESEFKNLGY
HHHHHHHHHHHHHCE		49.5428889911
334AcetylationKALESEFKNLGYRLV
HHHHHHHHHHCEEEE		47.4124489116
334SuccinylationKALESEFKNLGYRLV
HHHHHHHHHHCEEEE		47.4123954790
342PhosphorylationNLGYRLVSNGTDSHM
HHCEEEECCCCCCCE		33.8522369663
345PhosphorylationYRLVSNGTDSHMVLV
EEEECCCCCCCEEEE		38.2822369663
347PhosphorylationLVSNGTDSHMVLVSL
EECCCCCCCEEEEEH		17.2022369663
353PhosphorylationDSHMVLVSLREKGVD
CCCEEEEEHHHHCCC		19.9722369663
357AcetylationVLVSLREKGVDGARV
EEEEHHHHCCCCCHH		58.7724489116
370UbiquitinationRVEYICEKINIALNK
HHHHHHHHHHHHCCC		36.3222817900
377AcetylationKINIALNKNSIPGDK
HHHHHCCCCCCCCCH		53.5824489116
377UbiquitinationKINIALNKNSIPGDK
HHHHHCCCCCCCCCH		53.5823749301
384AcetylationKNSIPGDKSALVPGG
CCCCCCCHHHCCCCC		43.4724489116
385PhosphorylationNSIPGDKSALVPGGV
CCCCCCHHHCCCCCE		31.4128889911
400PhosphorylationRIGAPAMTTRGMGEE
EECCCCCCCCCCCHH		18.5627017623
418UbiquitinationRIVQYINKAVEFAQQ
HHHHHHHHHHHHHHH		44.2223749301
429PhosphorylationFAQQVQQSLPKDACR
HHHHHHHHCCCCHHC		29.5521551504
432AcetylationQVQQSLPKDACRLKD
HHHHHCCCCHHCHHH		64.3524489116
432UbiquitinationQVQQSLPKDACRLKD
HHHHHCCCCHHCHHH		64.3523749301
441AcetylationACRLKDFKAKVDEGS
HHCHHHHHHHHCCCC		58.3925381059
455AcetylationSDVLNTWKKEIYDWA
CHHHHHHHHHHHHHH		38.1924489116
455SuccinylationSDVLNTWKKEIYDWA
CHHHHHHHHHHHHHH		38.1923954790
455UbiquitinationSDVLNTWKKEIYDWA
CHHHHHHHHHHHHHH		38.1922817900
456UbiquitinationDVLNTWKKEIYDWAG
HHHHHHHHHHHHHHC		40.6923749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GLYC_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLYC_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLYC_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCN20_YEASTGCN20physical
11805826
GFA1_YEASTGFA1physical
11805826
C1TC_YEASTADE3genetic
11788966
C1TM_YEASTMIS1genetic
8852837
PSH1_YEASTPSH1physical
16554755
BAS1_YEASTBAS1physical
18719252
I23O_YEASTBNA2genetic
16941010
KYNU_YEASTBNA5genetic
16941010
TBS1_YEASTTBS1genetic
20093466
BCS1_YEASTBCS1genetic
20093466
HPRT_YEASTHPT1genetic
20093466
FCY2_YEASTFCY2genetic
20093466
PT122_YEASTPET122genetic
20093466
YEY6_YEASTYER156Cgenetic
20093466
KIP3_YEASTKIP3genetic
20093466
HTD2_YEASTHTD2genetic
20093466
COA4_YEASTCOA4genetic
20093466
MSS11_YEASTMSS11genetic
20093466
SWS2_YEASTSWS2genetic
20093466
QCR2_YEASTQCR2genetic
20093466
HPRT_YEASTHPT1genetic
21623372
FOLE_YEASTMET7genetic
21623372
FCY2_YEASTFCY2genetic
21623372
ATPO_YEASTATP5genetic
21623372
ADH3_YEASTADH3genetic
21623372
TBS1_YEASTTBS1genetic
27708008
BCS1_YEASTBCS1genetic
27708008
HPRT_YEASTHPT1genetic
27708008
FCY2_YEASTFCY2genetic
27708008
PT122_YEASTPET122genetic
27708008
YEY6_YEASTYER156Cgenetic
27708008
SDS3_YEASTSDS3genetic
27708008
LPLA_YEASTAIM22genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
PTK2_YEASTPTK2genetic
27708008
MRT4_YEASTMRT4genetic
27708008
HAP4_YEASTHAP4genetic
27708008
COXM1_YEASTCMC1genetic
27708008
PEX1_YEASTPEX1genetic
27708008
FPS1_YEASTFPS1genetic
27708008
LIPB_YEASTLIP2genetic
27708008
PKR1_YEASTPKR1genetic
27708008
HFA1_YEASTHFA1genetic
27708008
NGL2_YEASTNGL2genetic
27708008
SWS2_YEASTSWS2genetic
27708008
QCR2_YEASTQCR2genetic
27708008
MSH6_YEASTMSH6genetic
28416670
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLYC_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20; SER-26; THR-156;SER-194 AND SER-429, AND MASS SPECTROMETRY.

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