GFA1_YEAST - dbPTM
GFA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GFA1_YEAST
UniProt AC P14742
Protein Name Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene Name GFA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 717
Subcellular Localization
Protein Description Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins)..
Protein Sequence MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MCGIFGYCNYLVER
-CCCCCHHHHHHHHH		2.6930377154
10PhosphorylationGIFGYCNYLVERSRG
CCCHHHHHHHHHCCC		14.4630377154
15PhosphorylationCNYLVERSRGEIIDT
HHHHHHHCCCCHHHH		31.0030377154
49PhosphorylationIDGDEADSTFIYKQI
ECCCCCCCEEEHHHH		32.0627214570
54UbiquitinationADSTFIYKQIGKVSA
CCCEEEHHHHCCHHH		30.5317644757
58UbiquitinationFIYKQIGKVSALKEE
EEHHHHCCHHHHHHH		34.3517644757
63UbiquitinationIGKVSALKEEITKQN
HCCHHHHHHHHHHHC		53.6817644757
63AcetylationIGKVSALKEEITKQN
HCCHHHHHHHHHHHC		53.6822865919
63SuccinylationIGKVSALKEEITKQN
HCCHHHHHHHHHHHC		53.6823954790
68UbiquitinationALKEEITKQNPNRDV
HHHHHHHHHCCCCCE		54.4617644757
1252-HydroxyisobutyrylationITNFRELKTLLINKG
ECCHHHHHHHHHCCC		32.16-
131AcetylationLKTLLINKGYKFESD
HHHHHHCCCCCCCCC		57.5322865919
134UbiquitinationLLINKGYKFESDTDT
HHHCCCCCCCCCCCH		51.8523749301
134AcetylationLLINKGYKFESDTDT
HHHCCCCCCCCCCCH		51.8524489116
146UbiquitinationTDTECIAKLYLHLYN
CCHHHHHHHHHHHHH		20.1117644757
169UbiquitinationLDFHELTKLVLLELE
CCHHHHHHHHHHCCC		49.5817644757
184UbiquitinationGSYGLLCKSCHYPNE
CCCEEEEHHCCCCCC		56.9617644757
197UbiquitinationNEVIATRKGSPLLIG
CCEEEECCCCCEEEE		60.4317644757
199PhosphorylationVIATRKGSPLLIGVK
EEEECCCCCEEEEEC		18.5322369663
206UbiquitinationSPLLIGVKSEKKLKV
CCEEEEECCCCCEEE		47.9217644757
206AcetylationSPLLIGVKSEKKLKV
CCEEEEECCCCCEEE		47.9222865919
209UbiquitinationLIGVKSEKKLKVDFV
EEEECCCCCEEECEE		71.1817644757
210UbiquitinationIGVKSEKKLKVDFVD
EEECCCCCEEECEEE		49.8717644757
212UbiquitinationVKSEKKLKVDFVDVE
ECCCCCEEECEEECC		48.9517644757
233UbiquitinationGQPEIPLKSNNKSFG
CCCCCCCCCCCCCCC		45.8717644757
237UbiquitinationIPLKSNNKSFGLGPK
CCCCCCCCCCCCCHH		51.9523749301
237AcetylationIPLKSNNKSFGLGPK
CCCCCCCCCCCCCHH		51.9525381059
238PhosphorylationPLKSNNKSFGLGPKK
CCCCCCCCCCCCHHH		27.0322369663
245UbiquitinationSFGLGPKKAREFEAG
CCCCCHHHHHCCCCC		56.6717644757
253PhosphorylationAREFEAGSQNANLLP
HHCCCCCCCCCCCCC		27.5822369663
271PhosphorylationNEFNLRHSQSRAFLS
CCHHCCCCCCCEEEC		24.3422369663
273PhosphorylationFNLRHSQSRAFLSED
HHCCCCCCCEEECCC		28.7021440633
278PhosphorylationSQSRAFLSEDGSPTP
CCCCEEECCCCCCCC		27.4722369663
282PhosphorylationAFLSEDGSPTPVEFF
EEECCCCCCCCEEEE		37.6122369663
284PhosphorylationLSEDGSPTPVEFFVS
ECCCCCCCCEEEEEC		41.4822369663
291PhosphorylationTPVEFFVSSDAASVV
CCEEEEECCCHHHHH		19.8322369663
292PhosphorylationPVEFFVSSDAASVVK
CEEEEECCCHHHHHH		26.4322369663
296PhosphorylationFVSSDAASVVKHTKK
EECCCHHHHHHHCCE		29.2122369663
299UbiquitinationSDAASVVKHTKKVLF
CCHHHHHHHCCEEEE		43.3217644757
302UbiquitinationASVVKHTKKVLFLED
HHHHHHCCEEEEECC		40.3717644757
303UbiquitinationSVVKHTKKVLFLEDD
HHHHHCCEEEEECCC		45.3817644757
332PhosphorylationSRREVGASMTRSIQT
CHHHHHCHHHHHHHH		18.1122369663
334PhosphorylationREVGASMTRSIQTLE
HHHHCHHHHHHHHHH		20.8322369663
336PhosphorylationVGASMTRSIQTLEME
HHCHHHHHHHHHHHH		15.1922369663
339PhosphorylationSMTRSIQTLEMELAQ
HHHHHHHHHHHHHHH		24.0222369663
358UbiquitinationPYDHFMQKEIYEQPE
CCHHHHHHHHHHCCH		34.0017644757
358AcetylationPYDHFMQKEIYEQPE
CCHHHHHHHHHHCCH		34.0024489116
381UbiquitinationRIDYENNKVILGGLK
EEECCCCEEEECHHH		42.0823749301
381AcetylationRIDYENNKVILGGLK
EEECCCCEEEECHHH		42.0824489116
507UbiquitinationEIGVASTKAYTSQYI
CCCCCCCHHHHHHHH		36.5817644757
542AcetylationIEIIQGLKLIPGQIK
HHHHHHCCCCCCHHH		51.7124489116
542UbiquitinationIEIIQGLKLIPGQIK
HHHHHHCCCCCCHHH		51.7115699485
549AcetylationKLIPGQIKQVLKLEP
CCCCCHHHHHHHCCH		26.8524489116
553AcetylationGQIKQVLKLEPRIKK
CHHHHHHHCCHHHHH		52.5322865919
559UbiquitinationLKLEPRIKKLCATEL
HHCCHHHHHHHHHHH		40.7617644757
560UbiquitinationKLEPRIKKLCATELK
HCCHHHHHHHHHHHC		46.5623749301
567UbiquitinationKLCATELKDQKSLLL
HHHHHHHCCCHHHHH		52.4617644757
567AcetylationKLCATELKDQKSLLL
HHHHHHHCCCHHHHH		52.4625381059
570UbiquitinationATELKDQKSLLLLGR
HHHHCCCHHHHHHHC		53.8817644757
570AcetylationATELKDQKSLLLLGR
HHHHCCCHHHHHHHC		53.8824489116
608UbiquitinationGVLAGELKHGVLALV
CCCCHHCCCCEEEEE		33.7317644757
633AcetylationTRDSLFPKVVSSIEQ
CCHHHCHHHHHCHHH		48.1924489116
645UbiquitinationIEQVTARKGHPIIIC
HHHHHCCCCCCEEEE		60.1417644757
662UbiquitinationNDEVWAQKSKSIDLQ
CCCHHHHCCCCCCCC		52.7017644757
700UbiquitinationSYWLAVNKGIDVDFP
HHHHHHHCCCCCCCC		51.1215699485
712UbiquitinationDFPRNLAKSVTVE--
CCCCCHHCCCCCC--		48.9323749301
713PhosphorylationFPRNLAKSVTVE---
CCCCHHCCCCCC---		19.8821440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GFA1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GFA1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GFA1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDC2_YEASTPDC2physical
16554755
CLC1_YEASTCLC1physical
16554755
CEF1_YEASTCEF1physical
16554755
3HAO_YEASTBNA1genetic
21623372
ELO3_YEASTELO3genetic
21623372
THDH_YEASTILV1genetic
21623372
ERG2_YEASTERG2genetic
21623372
MET5_YEASTMET5genetic
21623372
ADK_YEASTADO1genetic
21623372
PDX3_YEASTPDX3genetic
21623372
CSG2_YEASTCSG2genetic
21623372
RBSK_YEASTRBK1genetic
21623372
KAD2_YEASTADK1genetic
21623372
ATC3_YEASTDRS2genetic
27708008
TPS1_YEASTTPS1genetic
27708008
PYC2_YEASTPYC2genetic
27708008
RER1_YEASTRER1genetic
27708008
SAC3_YEASTSAC3genetic
27708008
ALLA_YEASTDAL3genetic
27708008
VPS53_YEASTVPS53genetic
27708008
CDC24_YEASTCDC24genetic
27708008
KPC1_YEASTPKC1genetic
27708008
IPYR_YEASTIPP1genetic
27708008
ALG14_YEASTALG14genetic
27708008
UAP1_YEASTQRI1genetic
27708008
RPN5_YEASTRPN5genetic
27708008
GLE1_YEASTGLE1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
ERF3_YEASTSUP35genetic
27708008
GPI19_YEASTGPI19genetic
27708008
ACT_YEASTACT1genetic
27708008
DBF2_YEASTDBF2genetic
27708008
SYFB_YEASTFRS1genetic
27708008
RNA1_YEASTRNA1genetic
27708008
ARPC2_YEASTARC35genetic
27708008
PROF_YEASTPFY1genetic
27708008
GPI2_YEASTGPI2genetic
27708008
DEP1_YEASTDEP1genetic
27708008
H2A2_YEASTHTA2genetic
27708008
PFF1_YEASTPFF1genetic
27708008
MIC12_YEASTMIC12genetic
27708008
YB9Z_YEASTYBR284Wgenetic
27708008
SNF5_YEASTSNF5genetic
27708008
KCC4_YEASTKCC4genetic
27708008
SNT1_YEASTSNT1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
CYK3_YEASTCYK3genetic
27708008
FADH_YEASTSFA1genetic
27708008
PAR32_YEASTPAR32genetic
27708008
ARO1_YEASTARO1genetic
27708008
IRC4_YEASTIRC4genetic
27708008
YEW7_YEASTYER137Cgenetic
27708008
BEM2_YEASTBEM2genetic
27708008
MSP1_YEASTMSP1genetic
27708008
SLT2_YEASTSLT2genetic
27708008
BCK1_YEASTBCK1genetic
27708008
YJS1_YEASTYJL181Wgenetic
27708008
UBP12_YEASTUBP12genetic
27708008
YJ24_YEASTKCH1genetic
27708008
RL43A_YEASTRPL43Bgenetic
27708008
RL43B_YEASTRPL43Bgenetic
27708008
SPA2_YEASTSPA2genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
RCF1_YEASTRCF1genetic
27708008
PALI_YEASTRIM9genetic
27708008
SIW14_YEASTSIW14genetic
27708008
MKS1_YEASTMKS1genetic
27708008
YNM2_YEASTYNL122Cgenetic
27708008
PDE2_YEASTPDE2genetic
27708008
FUMH_YEASTFUM1genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GFA1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199; SER-238; SER-253;SER-332 AND THR-334, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332, AND MASSSPECTROMETRY.

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