UBP12_YEAST - dbPTM
UBP12_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBP12_YEAST
UniProt AC P39538
Protein Name Ubiquitin carboxyl-terminal hydrolase 12
Gene Name UBP12
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1254
Subcellular Localization
Protein Description Ubiquitin carboxyl-terminal hydrolase that recognizes ubiquitin chains that stabilize FZO1 and promote mitochondrial fusion. UBP12 deubiquitylates FZO1 only after oligomerization..
Protein Sequence MGSSDVSSRECSLVYNEDPDFTDGTTPCDRLGVDLMNVLDDKDEIKQESVPVSDREIEDTESDASAVSSFASANELIAEPHAASETNLGTNGQDGRNVLEQQRDVVARLIEENKETQKEGDKVCIVPKVWYDKFFDPDVTDPEDIGPINTRMICRDFENFVLEDYNRCPYLSIAEPVFNFLSEIYGMTSGSYPVVTNLVINQTTGELETEYNKWFFRLHYLTEKQDGRKRRHGQDDSIMYLSMSALNLVRDLVEKSMNLFFEKADHLDVNAVDFKIWFVSEGSDIATDSNVSTFLNSSYEITPLQFLELPIKKLLIPDMFENRLDKITSNPSDLVIEIKPIEGNHHWPSNYFAYNKLEPASGTTGLVNLGNTCYMNSALQCLVHIPQLRDYFLYDGYEDEINEENPLGYHGYVARAFSDLVQKLFQNRMSIMQRNAAFPPSMFKSTIGHFNSMFSGYMQQDSQEFLAFLLDSLHEDLNRIIKKEYTEKPSLSPGDDVNDWNVVKKLADDTWEMHLKRNCSVITDLFVGMYKSTLYCPECQNVSITFDPYNDVTLPLPVDTVWDKTIKIFPMNSPPLLLEVELSKSSTYMDLKNYVGKMSGLDPNTLFGCEIFSNQIYVNYESTESNAQFLTLQELIKPADDVIFYELPVTNDNEVIVPVLNTRIEKGYKNAMLFGVPFFITLKEDELNNPGAIRMKLQNRFVHLSGGYIPFPEPVGNRTDFADAFPLLVEKYPDVEFEQYKDILQYTSIKVTDKDKSFFSIKILSVEKEQQFASNNRTGPNFWTPISQLNLDKATDIDDKLEDVVKDIYNYSSLVDCAEGVLMQVDDEGDTEGSEAKNFSKPFQSGDDEENKETVTNNENVNNTNDRDEDMELTDDVEEDASTEPELTDKPEALDKIKDSLTSTPFAILSMNDIIVCEWSELGSNEAFSDDKIYNWENPATLPNKELENAKLERSNAKERTITLDDCLQLFSKPEILGLTDSWYCPTCKEHRQATKQIQLWNTPDILLIHLKRFESQRSFSDKIDATVNFPITDLDLSRYVVYKDDPRGLIYDLYAVDNHYGGLGGGHYTAYVKNFADNKWYYFDDSRVTETAPENSIAGSAYLLFYIRRHKDGNGLGSSKLQEIIQKSRHGYDERIKKIYDEQMKLYEFNKTDEEEDVSDDMIECNEDVQAPEYSNRSLEVGHIETQDCNDEDDNDDGERTNSGRRKLRLLKKVYKNNSGLGSSSTSEISEGCPENEVADLNLKNGVTLESPE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MGSSDVSSRE
-----CCCCCCCCCC		34.9127017623
12PhosphorylationDVSSRECSLVYNEDP
CCCCCCCCEEECCCC		19.0028889911
26PhosphorylationPDFTDGTTPCDRLGV
CCCCCCCCCCHHHCC		27.7023749301
49PhosphorylationKDEIKQESVPVSDRE
HHHHHHHCCCCCHHC		29.2728889911
53PhosphorylationKQESVPVSDREIEDT
HHHCCCCCHHCCCCC		25.5328889911
84PhosphorylationIAEPHAASETNLGTN
HCCCCCCCCCCCCCC		45.8228889911
86PhosphorylationEPHAASETNLGTNGQ
CCCCCCCCCCCCCCC		32.9928889911
430PhosphorylationKLFQNRMSIMQRNAA
HHHHHHHHHHHHHCC		16.2128889911
445PhosphorylationFPPSMFKSTIGHFNS
CCHHHHHHHHHHHHH		17.6227017623
446PhosphorylationPPSMFKSTIGHFNSM
CHHHHHHHHHHHHHH		31.4127017623
520PhosphorylationMHLKRNCSVITDLFV
HHHHHCCHHHHHHHH		21.8025704821
756AcetylationIKVTDKDKSFFSIKI
EEEECCCCCCEEEEE		55.7024489116
845PhosphorylationNFSKPFQSGDDEENK
CCCCCCCCCCCCCCC		44.5621440633
854PhosphorylationDDEENKETVTNNENV
CCCCCCCCCCCCCCC		33.9519823750
856PhosphorylationEENKETVTNNENVNN
CCCCCCCCCCCCCCC		39.4819823750
864PhosphorylationNNENVNNTNDRDEDM
CCCCCCCCCCCHHHC		33.0419823750
874PhosphorylationRDEDMELTDDVEEDA
CHHHCCCCCCHHHCC		19.4919823750
882PhosphorylationDDVEEDASTEPELTD
CCHHHCCCCCCHHCC		45.7019823750
883PhosphorylationDVEEDASTEPELTDK
CHHHCCCCCCHHCCC		58.2319823750
888PhosphorylationASTEPELTDKPEALD
CCCCCHHCCCHHHHH		40.0719823750
896AcetylationDKPEALDKIKDSLTS
CCHHHHHHHHHHCCC		53.1324489116
1016PhosphorylationIHLKRFESQRSFSDK
EEHHHHCCCCCCCCC		28.3419823750
1019PhosphorylationKRFESQRSFSDKIDA
HHHCCCCCCCCCCCE		22.8219823750
1021PhosphorylationFESQRSFSDKIDATV
HCCCCCCCCCCCEEE		38.9619823750
1141PhosphorylationDERIKKIYDEQMKLY
HHHHHHHHHHHHHHE		23.4721440633
1148PhosphorylationYDEQMKLYEFNKTDE
HHHHHHHEECCCCCC		16.9821440633
1153PhosphorylationKLYEFNKTDEEEDVS
HHEECCCCCCCCCCC		50.1528152593
1160PhosphorylationTDEEEDVSDDMIECN
CCCCCCCCCCCEECC		39.9728152593
1179PhosphorylationAPEYSNRSLEVGHIE
CCCCCCCCEEECCEE		32.8823749301
1202PhosphorylationDNDDGERTNSGRRKL
CCCCCCCCHHHHHHH		29.4521440633
1204PhosphorylationDDGERTNSGRRKLRL
CCCCCCHHHHHHHHH		32.8219779198
1220PhosphorylationKKVYKNNSGLGSSST
HHHHHCCCCCCCCCH		44.8028889911
1224PhosphorylationKNNSGLGSSSTSEIS
HCCCCCCCCCHHHHC		26.5921440633
1225PhosphorylationNNSGLGSSSTSEISE
CCCCCCCCCHHHHCC		35.5220377248
1226PhosphorylationNSGLGSSSTSEISEG
CCCCCCCCHHHHCCC		37.3428889911
1227PhosphorylationSGLGSSSTSEISEGC
CCCCCCCHHHHCCCC		32.1221440633
1228PhosphorylationGLGSSSTSEISEGCP
CCCCCCHHHHCCCCC		34.5820377248
1231PhosphorylationSSSTSEISEGCPENE
CCCHHHHCCCCCCCC		24.7221551504
1249PhosphorylationLNLKNGVTLESPE--
CCCCCCCEECCCC--		26.6319823750
1252PhosphorylationKNGVTLESPE-----
CCCCEECCCC-----		37.1222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBP12_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBP12_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBP12_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GPA1_YEASTGPA1physical
15519996
GEA1_YEASTGEA1physical
16554755
SEC66_YEASTSEC66genetic
17314980
SUS1_YEASTSUS1genetic
17314980
RGP1_YEASTRGP1genetic
17314980
NUP84_YEASTNUP84genetic
17314980
RSC6_YEASTRSC6genetic
17314980
FZO1_YEASTFZO1physical
23317502
SECU_YEASTPDS1physical
22072716
APC11_YEASTAPC11genetic
27708008
RPN6_YEASTRPN6genetic
27708008
CDC48_YEASTCDC48genetic
27708008
FAL1_YEASTFAL1genetic
27708008
NCS1_YEASTFRQ1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
SAD1_YEASTSAD1genetic
27708008
DAM1_YEASTDAM1genetic
27708008
RPN1_YEASTRPN1genetic
27708008
ATC7_YEASTNEO1genetic
27708008
MCM10_YEASTMCM10genetic
27708008
SSL1_YEASTSSL1genetic
27708008
NOG2_YEASTNOG2genetic
27708008
SGT1_YEASTSGT1genetic
27708008
OST2_YEASTOST2genetic
27708008
NAB3_YEASTNAB3genetic
27708008
RPN7_YEASTRPN7genetic
27708008
CDC48_YEASTCDC48physical
28966167
RAD23_YEASTRAD23physical
28966167
MUP3_YEASTMUP3genetic
27453043
CSK2C_YEASTCKB2genetic
27453043
PMIP_YEASTOCT1genetic
27453043
PLP1_YEASTPLP1genetic
27453043
YJ66_YEASTYJR096Wgenetic
27453043
PTR2_YEASTPTR2genetic
27453043
AZF1_YEASTAZF1genetic
27453043
TPM1_YEASTTPM1genetic
27453043
APC10_YEASTDOC1genetic
27453043
RCO1_YEASTRCO1genetic
27453043
MRC1_YEASTMRC1genetic
27453043
CYPC_YEASTCPR3genetic
27453043
TSC10_YEASTTSC10genetic
27453043
PGTB2_YEASTBET2genetic
27453043
RAS2_YEASTRAS2genetic
27453043
PUT2_YEASTPUT2genetic
27453043
UBA4_YEASTUBA4genetic
27453043
H2AZ_YEASTHTZ1genetic
27453043
MRE11_YEASTMRE11genetic
27453043
PYRD_YEASTURA1genetic
27453043
EAF3_YEASTEAF3genetic
27453043
SKY1_YEASTSKY1genetic
27453043
MSH2_YEASTMSH2genetic
27453043
MLP2_YEASTMLP2genetic
27453043
VPS72_YEASTVPS72genetic
27453043
PP4R3_YEASTPSY2genetic
27453043
PTPA1_YEASTRRD1genetic
27453043
GCR2_YEASTGCR2genetic
27453043
MET32_YEASTMET32genetic
27453043
PDK1_YEASTPKP1genetic
27453043
KPR4_YEASTPRS4genetic
27453043
SODC_YEASTSOD1genetic
27453043
YIA6_YEASTYIA6genetic
27453043
RPB3_YEASTRPB3genetic
27453043
YPT32_YEASTYPT32genetic
27453043
EAR1_YEASTEAR1genetic
27453043
PDI_YEASTPDI1genetic
27453043
AIM33_YEASTAIM33genetic
27453043
SHU1_YEASTSHU1genetic
27453043
SWI4_YEASTSWI4genetic
27453043
TDA5_YEASTTDA5genetic
27453043
BUB1_YEASTBUB1genetic
27453043
PPA5_YEASTPHO5genetic
27453043
RPAC1_YEASTRPC40genetic
27453043
MLP1_YEASTMLP1genetic
27453043
HSC82_YEASTHSC82genetic
27453043
DCAM_YEASTSPE2genetic
27453043
BXI1_YEASTBXI1genetic
27453043
KC12_YEASTYCK2genetic
27453043
JHD2_YEASTJHD2genetic
27453043
ADE_YEASTAAH1genetic
27453043
HSL1_YEASTHSL1genetic
27453043
YIM1_YEASTYIM1genetic
27453043
PNPH_YEASTPNP1genetic
27453043
ERG26_YEASTERG26genetic
27453043
PP4C_YEASTPPH3genetic
27453043
VPS1_YEASTVPS1genetic
27453043
CYPB_YEASTCPR2genetic
27453043
TOP3_YEASTTOP3genetic
27453043
ARGR1_YEASTARG80genetic
27453043
KMO_YEASTBNA4genetic
27453043
G3P3_YEASTTDH3genetic
27453043
RAD52_YEASTRAD52genetic
27453043
DCC1_YEASTDCC1genetic
27453043
RAD5_YEASTRAD5genetic
27453043
ATG1_YEASTATG1genetic
27453043
SRO7_YEASTSRO7genetic
27453043
KU70_YEASTYKU70genetic
27453043
CKS1_YEASTCKS1genetic
27453043
YPT31_YEASTYPT31genetic
27453043
PHO23_YEASTPHO23genetic
27453043
ACAC_YEASTACC1genetic
27453043
PPME1_YEASTPPE1genetic
27453043
AGP3_YEASTAGP3genetic
27453043
ACE2_YEASTACE2genetic
27453043
KCC4_YEASTKCC4genetic
27453043
ABF2_YEASTABF2genetic
27453043
RAD1_YEASTRAD1genetic
27453043
UBP2_YEASTUBP2physical
29309037
UBI4P_YEASTUBI4physical
29309037
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBP12_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-84; THR-86;SER-430; THR-1153; SER-1226 AND THR-1227, AND MASS SPECTROMETRY.

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