dbPTM

KPR4_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KPR4_YEAST
UniProt AC	P38063
Protein Name	Ribose-phosphate pyrophosphokinase 4
Gene Name	PRS4
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	326
Subcellular Localization	Cytoplasm .
Protein Description	5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)..
Protein Sequence	MNSESREDMAINSIKLLAGNSHPDLAEQISKKLGIPLSKVGVYQYSNKETSVTIGESLRDEDVYIIQTGIGEQEINDFLMELLILIHACKIASARKITTVIPNFPYARQDKKDKSRAPITAKLVANLLQTAGADHVITMDLHASQIQGFFHIPVDNLYAEPSVLNYIRTKTDFDNAILVSPDAGGAKRVAALADKLDLNFALIHKERQKANEVSKMVLVGDVTNKSCLLVDDMADTCGTLVKACDTLMEHGAKEVIAIVTHGIFSGSAREKLRNSRLSRIVCTNTVPVDLDLPIADQIDISPTFAEAIRRLHNGESVSYLFTHAPV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	REDMAINSIKLLAGN HHHHHHHHHHHHHCC	18.26	30377154
205	Acetylation	LNFALIHKERQKANE CCHHHHHHHHHHHHH	47.82	24489116
223	Phosphorylation	MVLVGDVTNKSCLLV EEEEECCCCCCEEEH	41.49	19795423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KPR4_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KPR4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KPR4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPR5_YEAST	PRS5	physical	11283351
KPR1_YEAST	PRS1	physical	18467557
KPR2_YEAST	PRS2	physical	18467557
IPK1_YEAST	IPK1	genetic	19269370
SNF1_YEAST	SNF1	genetic	19269370
VIP1_YEAST	VIP1	genetic	19269370
6PGD1_YEAST	GND1	genetic	21623372
IPK1_YEAST	IPK1	genetic	21623372
KTR5_YEAST	KTR5	genetic	21623372
OPT1_YEAST	OPT1	genetic	21623372
F16P_YEAST	FBP1	genetic	21623372
PHO84_YEAST	PHO84	genetic	21623372
PABC_YEAST	ABZ2	genetic	21623372
METX_YEAST	YML082W	genetic	21623372
ALLC_YEAST	DAL2	genetic	21623372
GPP1_YEAST	GPP1	genetic	21623372
COX8_YEAST	COX8	genetic	21623372
KPR1_YEAST	PRS1	physical	22615397
KPR5_YEAST	PRS5	physical	27744273
ACT_YEAST	ACT1	genetic	27708008
COPA_YEAST	COP1	genetic	27708008
ALG2_YEAST	ALG2	genetic	27708008
PRP18_YEAST	PRP18	genetic	27708008
CP51_YEAST	ERG11	genetic	27708008
PAN1_YEAST	PAN1	genetic	27708008
GSP1_YEAST	GSP1	genetic	27708008
GET3_YEAST	GET3	genetic	27708008
RAD9_YEAST	RAD9	genetic	27708008
IPK1_YEAST	IPK1	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
PEF1_YEAST	PEF1	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
VIP1_YEAST	VIP1	genetic	27708008
CTL1_YEAST	CTL1	genetic	27708008
VPS5_YEAST	VPS5	genetic	27708008
LCF1_YEAST	FAA1	genetic	27708008
HAP5_YEAST	HAP5	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KPR4_YEAST

Related Literatures of Post-Translational Modification