OPT1_YEAST - dbPTM
OPT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPT1_YEAST
UniProt AC P40897
Protein Name Oligopeptide transporter 1
Gene Name OPT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 799
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description High affinity transporter for glutathione. Also transports tetra- and pentapeptides like the opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr-Gly-Gly_Phe-Met) across the cell membrane..
Protein Sequence MSTIYRESDSLESEPSPTPTTIPIQINMEEEKKDAFVKNIDEDVNNLTATTDEEDRDPESQKFDRHSIQEEGLVWKGDPTYLPNSPYPEVRSAVSIEDDPTIRLNHWRTWFLTTVFVVVFAGVNQFFSLRYPSLEINFLVAQVVCYPIGRILALLPDWKCSKVPFFDLNPGPFTKKEHAVVTIAVALTSSTAYAMYILNAQGSFYNMKLNVGYQFLLVWTSQMIGYGAAGLTRRWVVNPASSIWPQTLISVSLFDSLHSRKVEKTVANGWTMPRYRFFLIVLIGSFIWYWVPGFLFTGLSYFNVILWGSKTRHNFIANTIFGTQSGLGALPITFDYTQVSQAMSGSVFATPFYVSANTYASVLIFFVIVLPCLYFTNTWYAKYMPVISGSTYDNTQNKYNVTKILNEDYSINLEKYKEYSPVFVPFSYLLSYALNFAAVIAVFVHCILYHGKDIVAKFKDRKNGGTDIHMRIYSKNYKDCPDWWYLLLQIVMIGLGFVAVCCFDTKFPAWAFVIAILISLVNFIPQGILEAMTNQHVGLNIITELICGYMLPLRPMANLLFKLYGFIVMRQGLNLSRDLKLAMYMKVSPRLIFAVQIYATIISGMVNVGVQEWMMHNIDGLCTTDQPNGFTCANGRTVFNASIIWSLPKYLFSSGRIYNPLMWFFLIGLLFPLAVYAVQWKFPKFKFAKHIHTPVFFTGPGNIPPSTPYNYSLFFAMSFCLNLIRKRWRAWFNKYNFVMGAGVEAGVAISVVIIFLCVQYPGGKLSWWGNNVWKRTYDNDYKKFYTLKKGETFGYDKWW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSTIYRESD
------CCCCCCCCC		24.4219823750
3Phosphorylation-----MSTIYRESDS
-----CCCCCCCCCC		22.2619823750
5Phosphorylation---MSTIYRESDSLE
---CCCCCCCCCCCC		14.3919823750
8PhosphorylationMSTIYRESDSLESEP
CCCCCCCCCCCCCCC		24.4119779198
10PhosphorylationTIYRESDSLESEPSP
CCCCCCCCCCCCCCC		43.2319823750
13PhosphorylationRESDSLESEPSPTPT
CCCCCCCCCCCCCCC		61.1619795423
16PhosphorylationDSLESEPSPTPTTIP
CCCCCCCCCCCCCEE		37.0419823750
18PhosphorylationLESEPSPTPTTIPIQ
CCCCCCCCCCCEEEE		37.2919823750
20PhosphorylationSEPSPTPTTIPIQIN
CCCCCCCCCEEEEEC		39.5719823750
21PhosphorylationEPSPTPTTIPIQINM
CCCCCCCCEEEEECC		26.4219823750
46N-linked_GlycosylationNIDEDVNNLTATTDE
CCCHHHHHHCCCCCC		38.32-
48PhosphorylationDEDVNNLTATTDEED
CHHHHHHCCCCCCCC		24.8719823750
50PhosphorylationDVNNLTATTDEEDRD
HHHHHCCCCCCCCCC		29.5519823750
51PhosphorylationVNNLTATTDEEDRDP
HHHHCCCCCCCCCCC		38.6619823750
60PhosphorylationEEDRDPESQKFDRHS
CCCCCCCCCCCCCHH		44.0219795423
67PhosphorylationSQKFDRHSIQEEGLV
CCCCCCHHCCCCCCE		27.1920377248
584PhosphorylationRDLKLAMYMKVSPRL
HHHHHHHHCCCCHHH		6.5428889911
640N-linked_GlycosylationANGRTVFNASIIWSL
CCCCEEEEEEHHHHH		28.57-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OPT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OPT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GSH1_YEASTGSH1genetic
10788431
ATG27_YEASTATG27genetic
16269340
COPE_YEASTSEC28genetic
16269340
DYN3_YEASTDYN3genetic
16269340
GUP1_YEASTGUP1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
ATC1_YEASTPMR1genetic
16269340
CHO2_YEASTCHO2genetic
16269340
PTR2_YEASTPTR2genetic
17179087
DUG1_YEASTDUG1genetic
19346245
RSC2_YEASTRSC2genetic
20093466
GSHB_YEASTGSH2genetic
20093466
IRE1_YEASTIRE1genetic
21478822
GSHB_YEASTGSH2genetic
21623372
EF1A_YEASTTEF2physical
22940862
HSP71_YEASTSSA1physical
22940862
DED1_YEASTDED1physical
22940862
RL4A_YEASTRPL4Aphysical
22940862
SSB1_YEASTSSB1physical
22940862
HSP72_YEASTSSA2physical
22940862
G3P3_YEASTTDH3physical
22940862
GSH1_YEASTGSH1genetic
25130273
SEF1_YEASTSEF1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
H4_YEASTHHF1genetic
27708008
GAL10_YEASTGAL10genetic
27708008
GSHB_YEASTGSH2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPT1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-50 AND THR-51, AND MASSSPECTROMETRY.

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