| UniProt ID | ATC1_YEAST | |
|---|---|---|
| UniProt AC | P13586 | |
| Protein Name | Calcium-transporting ATPase 1 | |
| Gene Name | PMR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 950 | |
| Subcellular Localization |
Golgi apparatus membrane Multi-pass membrane protein. |
|
| Protein Description | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway.. | |
| Protein Sequence | MSDNPFNASLLDEDSNREREILDATAEALSKPSPSLEYCTLSVDEALEKLDTDKNGGLRSSNEANNRRSLYGPNEITVEDDESLFKKFLSNFIEDRMILLLIGSAVVSLFMGNIDDAVSITLAIFIVVTVGFVQEYRSEKSLEALNKLVPAECHLMRCGQESHVLASTLVPGDLVHFRIGDRIPADIRIIEAIDLSIDESNLTGENEPVHKTSQTIEKSSFNDQPNSIVPISERSCIAYMGTLVKEGHGKGIVVGTGTNTSFGAVFEMMNNIEKPKTPLQLTMDKLGKDLSLVSFIVIGMICLVGIIQGRSWLEMFQISVSLAVAAIPEGLPIIVTVTLALGVLRMAKRKAIVRRLPSVETLGSVNVICSDKTGTLTSNHMTVSKLWCLDSMSNKLNVLSLDKNKKTKNSNGNLKNYLTEDVRETLTIGNLCNNASFSQEHAIFLGNPTDVALLEQLANFEMPDIRNTVQKVQELPFNSKRKLMATKILNPVDNKCTVYVKGAFERILEYSTSYLKSKGKKTEKLTEAQKATINECANSMASEGLRVFGFAKLTLSDSSTPLTEDLIKDLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHIIMITGDSENTAVNIAKQIGIPVIDPKLSVLSGDKLDEMSDDQLANVIDHVNIFARATPEHKLNIVRALRKRGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVAKEASDMVLTDDDFSTILTAIEEGKGIFNNIQNFLTFQLSTSVAALSLVALSTAFKLPNPLNAMQILWINILMDGPPAQSLGVEPVDHEVMKKPPRKRTDKILTHDVMKRLLTTAACIIVGTVYIFVKEMAEDGKVTARDTTMTFTCFVFFDMFNALACRHNTKSIFEIGFFTNKMFNYAVGLSLLGQMCAIYIPFFQSIFKTEKLGISDILLLLLISSSVFIVDELRKLWTRKKNEEDSTYFSNV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSDNPFNAS ------CCCCCCCHH | 46.20 | 22814378 | |
| 2 | Phosphorylation | ------MSDNPFNAS ------CCCCCCCHH | 46.20 | 22369663 | |
| 9 | Phosphorylation | SDNPFNASLLDEDSN CCCCCCHHHCCCCCH | 30.48 | 22369663 | |
| 15 | Phosphorylation | ASLLDEDSNREREIL HHHCCCCCHHHHHHH | 35.42 | 22369663 | |
| 49 | Ubiquitination | SVDEALEKLDTDKNG EHHHHHHHCCCCCCC | 53.14 | 17644757 | |
| 54 | Ubiquitination | LEKLDTDKNGGLRSS HHHCCCCCCCCCCCC | 60.63 | 23749301 | |
| 86 | Acetylation | EDDESLFKKFLSNFI CCCHHHHHHHHHHHC | 48.16 | 24489116 | |
| 140 | Ubiquitination | VQEYRSEKSLEALNK HHHHCCHHHHHHHHH | 62.68 | 23749301 | |
| 147 | Ubiquitination | KSLEALNKLVPAECH HHHHHHHHHCCCCHH | 52.27 | 24961812 | |
| 218 | Acetylation | KTSQTIEKSSFNDQP CCCCCEEHHHCCCCC | 47.77 | 24489116 | |
| 218 | Ubiquitination | KTSQTIEKSSFNDQP CCCCCEEHHHCCCCC | 47.77 | 23749301 | |
| 227 | Phosphorylation | SFNDQPNSIVPISER HCCCCCCCEEEECHH | 31.48 | 25752575 | |
| 242 | Phosphorylation | SCIAYMGTLVKEGHG HHHHHHCCEEECCCC | 16.31 | 24909858 | |
| 372 | Ubiquitination | VNVICSDKTGTLTSN EEEEEECCCCCEECC | 32.34 | 17644757 | |
| 373 | Phosphorylation | NVICSDKTGTLTSNH EEEEECCCCCEECCC | 40.15 | 19823750 | |
| 375 | Phosphorylation | ICSDKTGTLTSNHMT EEECCCCCEECCCEE | 31.90 | 19823750 | |
| 377 | Phosphorylation | SDKTGTLTSNHMTVS ECCCCCEECCCEEEE | 27.59 | 19795423 | |
| 378 | Phosphorylation | DKTGTLTSNHMTVSK CCCCCEECCCEEEEE | 28.05 | 19823750 | |
| 382 | Phosphorylation | TLTSNHMTVSKLWCL CEECCCEEEEEEHHH | 17.68 | 19823750 | |
| 384 | Phosphorylation | TSNHMTVSKLWCLDS ECCCEEEEEEHHHHH | 16.92 | 19823750 | |
| 385 | Ubiquitination | SNHMTVSKLWCLDSM CCCEEEEEEHHHHHH | 41.49 | 17644757 | |
| 403 | Acetylation | LNVLSLDKNKKTKNS CCEEECCCCCCCCCC | 75.78 | 24489116 | |
| 405 | Acetylation | VLSLDKNKKTKNSNG EEECCCCCCCCCCCC | 68.51 | 24489116 | |
| 415 | Ubiquitination | KNSNGNLKNYLTEDV CCCCCCHHHHCCHHH | 47.77 | 23749301 | |
| 471 | Ubiquitination | DIRNTVQKVQELPFN CHHHHHHHHHHCCCC | 41.36 | 23749301 | |
| 480 | Succinylation | QELPFNSKRKLMATK HHCCCCCCCCCEEEE | 55.44 | 23954790 | |
| 480 | Ubiquitination | QELPFNSKRKLMATK HHCCCCCCCCCEEEE | 55.44 | 17644757 | |
| 487 | Ubiquitination | KRKLMATKILNPVDN CCCCEEEEECCCCCC | 35.34 | 23749301 | |
| 530 | Ubiquitination | EKLTEAQKATINECA HHCHHHHHHHHHHHH | 55.32 | 23749301 | |
| 539 | Phosphorylation | TINECANSMASEGLR HHHHHHHHHHHHCCE | 9.37 | 28889911 | |
| 542 | Phosphorylation | ECANSMASEGLRVFG HHHHHHHHHCCEEEE | 24.45 | 28889911 | |
| 670 | Ubiquitination | NIVRALRKRGDVVAM HHHHHHHHCCCEEEE | 62.68 | 17644757 | |
| 689 | Ubiquitination | VNDAPALKLSDIGVS CCCCCCCHHHHHCCC | 48.31 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ATC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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