CASP_YEAST - dbPTM
CASP_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CASP_YEAST
UniProt AC P34237
Protein Name Protein CASP
Gene Name COY1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 679
Subcellular Localization Golgi apparatus membrane
Single-pass type IV membrane protein .
Protein Description May be involved in intra-Golgi transport..
Protein Sequence MDTSVYSHALDIWAKADLTNLQRELDADVIEIKDKETLSLNSRKSLATETKKFKKLEPEEKLNNVNKIIKQYQREIDNLTQRSKFSEKVLFDVYEKLSEAPDPQPLLQSSLEKLGKIDDSKELKEKISYLEDKLAKYADYETLKSRLLDLEQSSAKTLAKRLTAKTQEINSTWEEKGRNWKEREADLLKQLTNVQEQNKALEAKISKNIDIEGNGNEDGDQENNQKEVSTRIAEYNLVTQELETTQARIYQLEKRNEELSGALAKATSEAEKETELHAKELKLNQLESENALLSASYEQERKSTSHAINELKEQLNSVVAESESYKSELETVRRKLNNYSDYNKIKEELSALKKIEFGVNEDDSDNDIRSEDKNDNTFESSLLSANKKLQATLAEYRSKSTAQEEERNELKKSVDQLKQQIATLKEANEKLETDLEKVENVSPHFNETASMMSGVTRQMNNRTSHKMSPTSSIIGIPEDGELSGNQSTILPIVTKQRDRFRSRNMDLEKQLRQGNSEKGKLKLEISKLKGDNTKLYERIRYLQSYNNNNAPVNQSTERIDVESQYSRVYDESLHPMANFRQNELNHYKNKKLSALEKLFSSFAKVILQNKMTRMVFLFYCIGLHGLVFMMSMYVINISGYMTPEVGIVQSAKSSSNLNGGLGGAEKVAAGVGSVHGINR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
83PhosphorylationIDNLTQRSKFSEKVL
HHHHHHHHHHCHHHH		28.3827017623
113AcetylationLLQSSLEKLGKIDDS
HHHHHHHHHCCCCCC		68.7624489116
121UbiquitinationLGKIDDSKELKEKIS
HCCCCCCHHHHHHHH		74.2423749301
133AcetylationKISYLEDKLAKYADY
HHHHHHHHHHHHCCH		40.7524489116
176AcetylationINSTWEEKGRNWKER
HHHHHHHHCCCHHHH		52.2124489116
226UbiquitinationGDQENNQKEVSTRIA
CCCCCCHHHHHHHHH		63.3123749301
260PhosphorylationEKRNEELSGALAKAT
HHHHHHHHHHHHHHC		25.8727214570
305PhosphorylationEQERKSTSHAINELK
HHHHHHHHHHHHHHH		20.2928889911
339PhosphorylationVRRKLNNYSDYNKIK
HHHHHHCCHHHHHHH		11.2228889911
364PhosphorylationFGVNEDDSDNDIRSE
CCCCCCCCCCCCCCC		51.1122369663
370PhosphorylationDSDNDIRSEDKNDNT
CCCCCCCCCCCCCCC		50.9420377248
377PhosphorylationSEDKNDNTFESSLLS
CCCCCCCCHHHHHHH		31.4819823750
380PhosphorylationKNDNTFESSLLSANK
CCCCCHHHHHHHHHH		23.3024961812
381PhosphorylationNDNTFESSLLSANKK
CCCCHHHHHHHHHHH		26.5724961812
384PhosphorylationTFESSLLSANKKLQA
CHHHHHHHHHHHHHH		34.7819823750
388AcetylationSLLSANKKLQATLAE
HHHHHHHHHHHHHHH		45.7124489116
413PhosphorylationERNELKKSVDQLKQQ
HHHHHHHHHHHHHHH		29.3728889911
418AcetylationKKSVDQLKQQIATLK
HHHHHHHHHHHHHHH		34.2324489116
442PhosphorylationLEKVENVSPHFNETA
HHHHHHCCHHHHHHH		25.0024961812
448PhosphorylationVSPHFNETASMMSGV
CCHHHHHHHHHHHHH		25.7419779198
450PhosphorylationPHFNETASMMSGVTR
HHHHHHHHHHHHHHH		23.5717330950
453PhosphorylationNETASMMSGVTRQMN
HHHHHHHHHHHHHHC		22.8217330950
456PhosphorylationASMMSGVTRQMNNRT
HHHHHHHHHHHCCCC		20.7924961812
463PhosphorylationTRQMNNRTSHKMSPT
HHHHCCCCCCCCCCC		36.9922369663
464PhosphorylationRQMNNRTSHKMSPTS
HHHCCCCCCCCCCCC		20.2022369663
466UbiquitinationMNNRTSHKMSPTSSI
HCCCCCCCCCCCCCE		40.6223749301
468PhosphorylationNRTSHKMSPTSSIIG
CCCCCCCCCCCCEEE		29.8122369663
470PhosphorylationTSHKMSPTSSIIGIP
CCCCCCCCCCEEECC		28.0022369663
471PhosphorylationSHKMSPTSSIIGIPE
CCCCCCCCCEEECCC		23.9522890988
472PhosphorylationHKMSPTSSIIGIPED
CCCCCCCCEEECCCC		22.2422369663
483PhosphorylationIPEDGELSGNQSTIL
CCCCCCCCCCCCCEE		31.2522890988
487PhosphorylationGELSGNQSTILPIVT
CCCCCCCCCEEEEEH		22.7822890988
488PhosphorylationELSGNQSTILPIVTK
CCCCCCCCEEEEEHH		19.4422890988
494PhosphorylationSTILPIVTKQRDRFR
CCEEEEEHHHHHHHH		23.3722369663
509AcetylationSRNMDLEKQLRQGNS
HCCCCHHHHHHCCCC		63.0324489116
544PhosphorylationERIRYLQSYNNNNAP
HHHHHHHHHCCCCCC		27.5121126336
555PhosphorylationNNAPVNQSTERIDVE
CCCCCCCCCCCCCHH		27.3422369663
556PhosphorylationNAPVNQSTERIDVES
CCCCCCCCCCCCHHH		21.3722369663
563PhosphorylationTERIDVESQYSRVYD
CCCCCHHHHHHHHHC		33.9822369663
565PhosphorylationRIDVESQYSRVYDES
CCCHHHHHHHHHCCC		14.0222369663
566PhosphorylationIDVESQYSRVYDESL
CCHHHHHHHHHCCCC		13.9722369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CASP_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CASP_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CASP_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPC19_YEASTSPC19physical
11087867
RUD3_YEASTRUD3genetic
16269340
GET2_YEASTGET2genetic
16269340
SCS7_YEASTSCS7genetic
16269340
TGL1_YEASTTGL1genetic
16269340
SEC66_YEASTSEC66genetic
16269340
ATC1_YEASTPMR1genetic
16269340
MTC1_YEASTMTC1genetic
16269340
PGA3_YEASTPGA3genetic
16269340
RGP1_YEASTRGP1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
RUD3_YEASTRUD3physical
19591838
SPC19_YEASTSPC19physical
22875988
GCN20_YEASTGCN20physical
22875988
MPS2_YEASTMPS2physical
22875988
SPR3_YEASTSPR3physical
22875988
LAM4_YEASTYHR080Cphysical
22875988
SET2_YEASTSET2physical
22875988
RE107_YEASTREC107physical
22875988
LHS1_YEASTLHS1physical
22875988
SPC72_YEASTSPC72physical
22875988
AP2A_YEASTAPL3physical
22875988
HSP73_YEASTSSA3physical
22875988
SP381_YEASTSPP381physical
22875988
RGD1_YEASTRGD1physical
22875988
ARE1_YEASTARE1physical
22875988
NHP10_YEASTNHP10physical
22875988
YET3_YEASTYET3physical
22875988
ATIF_YEASTINH1physical
22875988
ASF2_YEASTASF2physical
22875988
SYSC_YEASTSES1physical
22875988
TAF12_YEASTTAF12physical
22875988
NGG1_YEASTNGG1physical
22875988
YAP6_YEASTYAP6physical
22875988
HDA2_YEASTHDA2physical
22875988
PEP7_YEASTPEP7physical
22875988
EAF1_YEASTEAF1physical
22875988
RRP17_YEASTRRP17physical
22875988
GCN4_YEASTGCN4physical
22875988
YEF3_YEASTYEL043Wphysical
22875988
TSC11_YEASTTSC11physical
22875988
PEA2_YEASTPEA2physical
22875988
SP105_YEASTSPC105physical
22875988
ATG1_YEASTATG1physical
22875988
SEC9_YEASTSEC9physical
22875988
NNF2_YEASTNNF2physical
22875988
NOL10_YEASTENP2physical
22875988
TBP7_YEASTYTA7physical
22875988
TAF1_YEASTTAF1physical
22875988
KEL1_YEASTKEL1physical
22875988
SKN7_YEASTSKN7physical
22875988
YAP5_YEASTYAP5physical
22875988
GRP78_YEASTKAR2physical
22875988
SNX4_YEASTSNX4physical
22875988
NET1_YEASTNET1physical
22875988
SWE1_YEASTSWE1physical
22875988
NNF1_YEASTNNF1physical
22875988
SGM1_YEASTSGM1physical
22875988
DID4_YEASTDID4physical
22875988
STB6_YEASTSTB6physical
22875988
SMY1_YEASTSMY1physical
22875988
RT22_YEASTRSM22physical
22875988
CASP_YEASTCOY1physical
22875988
DID2_YEASTDID2physical
22875988
NOC3_YEASTNOC3physical
22875988
SNF7_YEASTSNF7physical
22875988
YL031_YEASTYLR031Wphysical
22875988
MDN1_YEASTMDN1physical
22875988
VTA1_YEASTVTA1physical
22875988
FAR10_YEASTFAR10physical
22875988
FMP27_YEASTFMP27physical
22875988
SUB1_YEASTSUB1physical
22875988
FAR3_YEASTFAR3physical
22875988
VPS20_YEASTVPS20physical
22875988
CIK1_YEASTCIK1physical
22875988
EIF3C_YEASTNIP1physical
22875988
MET4_YEASTMET4physical
22875988
PFD4_YEASTGIM3physical
22875988
IPI3_YEASTIPI3physical
22875988
CNM67_YEASTCNM67physical
22875988
JJJ1_YEASTJJJ1physical
22875988
YAP7_YEASTYAP7physical
22875988
VPS5_YEASTVPS5physical
22875988
SGO1_YEASTSGO1physical
22875988
ULS1_YEASTULS1physical
22875988
BFR1_YEASTBFR1physical
22875988
TBCA_YEASTRBL2physical
22875988
TEA1_YEASTTEA1physical
22875988
RQC2_YEASTTAE2physical
22875988
SVL3_YEASTSVL3physical
22875988
NOP53_YEASTNOP53physical
22875988
NIP80_YEASTNIP100physical
22875988
YP216_YEASTYPL216Wphysical
22875988
BMS1_YEASTBMS1physical
22875988
BBP1_YEASTBBP1physical
22875988
YAP8_YEASTARR1physical
22875988
MAD1_YEASTMAD1physical
22875988
BLI1_YEASTBLI1physical
22875988
NUF2_YEASTNUF2physical
22875988
MPC54_YEASTMPC54physical
22875988
TBP6_YEASTYTA6physical
22875988
GYP5_YEASTGYP5physical
22875988
ATG11_YEASTATG11physical
22875988
ATC1_YEASTPMR1genetic
23891562
MNN11_YEASTMNN11genetic
23891562
GET2_YEASTGET2genetic
23891562
RGP1_YEASTRGP1genetic
23891562
RIC1_YEASTRIC1genetic
23891562
MTC1_YEASTMTC1genetic
23891562
RUD3_YEASTRUD3genetic
23891562
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CASP_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364; SER-450; THR-463;SER-468; THR-470; SER-471 AND SER-555, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364 AND SER-450, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-463, AND MASSSPECTROMETRY.

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