ULS1_YEAST - dbPTM
ULS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ULS1_YEAST
UniProt AC Q08562
Protein Name ATP-dependent helicase ULS1
Gene Name ULS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1619
Subcellular Localization Nucleus .
Protein Description ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates..
Protein Sequence MAAVPTIDLTLADSDNEDIFHSFSSSTSVDKIDIRKENGKLRMAGLEVAQSNDDAARQAFHVFKTNISNNETFDTILSKSKTITDSTFNNEKSSNEVKQQQVLKEETMGSSNDEKKTQESSPSAEMIKLFYENDDVPLSDSFKQKEEGKRINQDEQVKENICGISSSYVSKDYDGVEDDFEPNTCQDSNLDFQEEKLNLNNKPSQQQFSDPETKDNSLKSENKDQIKGVTTTSYRDLPIESSAFQDSETQNNSKNTIPNIVNEKRTPALPSNLSSVESSLKNETAKVEGKTTVRLPGLQNNVALLEQEQSELFKHFSEQPVDISDFGRKIKRKHSGDFADNKILKRPILPSKNMDHTTHNSHDSEQKNSSIIILSDEDESGAGINDIESPLKVSEPNTADALRSSVPEVISLLDLPNIDLNNSVIKEASGSNSIPTSETDAQSSSSSVLQGTIMTEQATQSSQHECNSSLDTLKKNHQKLLKDLNSRESELRNALSCCKTNSEILRRKLSRREKEVSDAEKHWQLLLTSMARGGRTISSTQQILVDEAENQLNKLKEKRQLTKSKLDSINLKMYNYNEQWKSFVHSKNINLQKSLAALERSARDSKASATVNKRNECLAEKEKLDQMLKEGTLSFSTYKQLTGEIQQKLNDLKLGDQRTTDINSVLPIVRQPLAKRDLFIKSIDTAKDLLAKNTSRTEMTKRILYRHLDNLVSYKNFFEDGRSLIDINRRHVAHESAQILFTNGVKMPIVFETLQDYGIKFSNPAIVNPDRRAQYFKSIEVARDLISKSTRSEDAKRKITRFLNIIEEFRKDIDTGFPPTPLKREGVGKAVVGLRQQGLKMDRLYENLRRYKIPITSEELLQQSYLFPVNADQRPPSNWNIVENTEDTSSTANDLSMQDEFHISNMHAAEDQEQIRALLENVKQSESIIDGEALTPEDMTVNLLKHQRLGLHWLLQVENSAKKGGLLADDMGLGKTIQAIALMLANRSEESKCKTNLIVAPVSVLRVWKGELETKVKKRAKFTTFIFGGSGNGKVKHWRDLARYDAVLVSYQTLANEFKKHWPKKLDGEQNQLPAVPHIQALNRLKTSNEYYSPFFCNDSTFYRILLDEGQNIKNKNTRASKACCTINGMYRWVLSGTPIQNSMDELYSLIRFLRIPPYHKEQRFKLDIGRFFQRNKQYQYDNEDRKNALRKVRVLLNAIMLRRSKADKIDGKPLLELPPKIVEVDESRLKGEELKFYTALESKNQALAKKLLNNSTRGSYSSVLTLLLRLRQACCHSELVVMGEKKAEGTKVANGKSFEDDWLRLYYKITHMSGEAQAQVITSMNSMTCFWCMEQLEPEAMSVLTGCGHLICDTCIEPFIEESSMLPQAKKTKGGAFAIPCKDCQRLTNEKDIVSHKLYDQVINQGFTEEDLHAEYLSEMEKQKIQQKNVYVPNFESLEPSTKIEQCIQVIQRVFDESATEKIIIFSQFTTFFEILEHFLKNKLNFPYLKYIGSMNAQRRSDVINEFYRDPEKRILLISMKAGNSGLTLTCANHVVIVDPFWNPYVEEQAQDRCYRISQTKKVQVHKLFIKDSVEDRISELQKRKKEMVDSAMDPGKIKEVNSLGRRELGFLFGLNAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
111PhosphorylationKEETMGSSNDEKKTQ
HHHHCCCCCCHHHHH		42.4428889911
117PhosphorylationSSNDEKKTQESSPSA
CCCCHHHHHCCCCCH		48.9521440633
120PhosphorylationDEKKTQESSPSAEMI
CHHHHHCCCCCHHHH		37.4222369663
121PhosphorylationEKKTQESSPSAEMIK
HHHHHCCCCCHHHHH		23.3222369663
123PhosphorylationKTQESSPSAEMIKLF
HHHCCCCCHHHHHHH		38.5222369663
139PhosphorylationENDDVPLSDSFKQKE
HCCCCCCCHHHCCHH		25.7428152593
141PhosphorylationDDVPLSDSFKQKEEG
CCCCCCHHHCCHHHC		30.8528152593
204PhosphorylationLNLNNKPSQQQFSDP
HCCCCCCCCCCCCCC		42.0822369663
209PhosphorylationKPSQQQFSDPETKDN
CCCCCCCCCCCCCCC		48.1722369663
213PhosphorylationQQFSDPETKDNSLKS
CCCCCCCCCCCCCCC		49.4322369663
217PhosphorylationDPETKDNSLKSENKD
CCCCCCCCCCCCCHH		47.5128889911
231PhosphorylationDQIKGVTTTSYRDLP
HHCCCCEECEECCCC		16.0230377154
317PhosphorylationSELFKHFSEQPVDIS
HHHHHHHHCCCCCHH		34.7321440633
335PhosphorylationRKIKRKHSGDFADNK
HHHHHHCCCCCCCCC		42.9919795423
370PhosphorylationDSEQKNSSIIILSDE
CCCCCCCEEEEEECC		27.4819779198
375PhosphorylationNSSIIILSDEDESGA
CCEEEEEECCCCCCC		28.6628889911
380PhosphorylationILSDEDESGAGINDI
EEECCCCCCCCCCCC		46.3930377154
634PhosphorylationMLKEGTLSFSTYKQL
HHHHCCCCHHHHHHH		19.5927214570
778PhosphorylationRRAQYFKSIEVARDL
HHHHHHHHHHHHHHH		17.6827017623
787PhosphorylationEVARDLISKSTRSED
HHHHHHHHHCCCCHH		28.0527017623
1023PhosphorylationVKKRAKFTTFIFGGS
HHHHCCEEEEEECCC		21.7919823750
1024PhosphorylationKKRAKFTTFIFGGSG
HHHCCEEEEEECCCC		20.1919823750
1030PhosphorylationTTFIFGGSGNGKVKH
EEEEECCCCCCCCCH		29.4819795423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ULS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ULS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ULS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NOP2_YEASTNOP2physical
11805837
IF6_YEASTTIF6physical
11805837
ATG7_YEASTATG7physical
11805837
SIR4_YEASTSIR4physical
9271422
HPR1_YEASTHPR1physical
16554755
MFT1_YEASTMFT1physical
16554755
THO2_YEASTTHO2physical
16554755
RAP1_YEASTRAP1genetic
17314980
BMH1_YEASTBMH1genetic
17314980
RPC10_YEASTRPC11genetic
17314980
SWC5_YEASTSWC5genetic
17314980
SLX5_YEASTSLX5genetic
17314980
SLX8_YEASTSLX8genetic
17314980
RGP1_YEASTRGP1genetic
17314980
SWR1_YEASTSWR1genetic
17314980
TAF12_YEASTTAF12genetic
17314980
AF9_YEASTYAF9genetic
17314980
SUS1_YEASTSUS1genetic
17314980
SWC3_YEASTSWC3genetic
17314980
GET1_YEASTGET1genetic
17314980
TAF13_YEASTTAF13genetic
17314980
RFC3_YEASTRFC3genetic
17314980
RFC4_YEASTRFC4genetic
17314980
RFA2_YEASTRFA2genetic
17314980
LSM6_YEASTLSM6genetic
17314980
ELP1_YEASTIKI3genetic
17314980
RAD50_YEASTRAD50genetic
17314980
TAF9_YEASTTAF9genetic
17314980
VPS72_YEASTVPS72genetic
17314980
CSM3_YEASTCSM3genetic
17314980
PFD6_YEASTYKE2genetic
17314980
VPS71_YEASTVPS71genetic
17314980
SRB8_YEASTSRB8genetic
17314980
SGF73_YEASTSGF73genetic
17314980
BEM2_YEASTBEM2genetic
17314980
SSL1_YEASTSSL1genetic
17314980
CDC73_YEASTCDC73genetic
17314980
HSP72_YEASTSSA2physical
19536198
SSB1_YEASTSSB1physical
19536198
MGA2_YEASTMGA2genetic
19547744
RAD54_YEASTRAD54genetic
20864034
RDH54_YEASTRDH54genetic
20864034
RAD51_YEASTRAD51genetic
20864034
CIN1_YEASTCIN1genetic
20959818
ARO80_YEASTARO80genetic
20959818
SET2_YEASTSET2genetic
20959818
URE2_YEASTURE2genetic
20959818
RTF1_YEASTRTF1genetic
20959818
VPS71_YEASTVPS71genetic
20959818
LSM6_YEASTLSM6genetic
20959818
WTM2_YEASTWTM2genetic
20959818
RPA34_YEASTRPA34genetic
20959818
RPA14_YEASTRPA14genetic
20959818
AF9_YEASTYAF9genetic
20959818
GLN3_YEASTGLN3genetic
20959818
LEO1_YEASTLEO1genetic
20959818
YRR1_YEASTYRR1genetic
20959818
EAF7_YEASTEAF7genetic
20959818
TFB2_YEASTTFB2genetic
20959818
YPT6_YEASTYPT6genetic
20959818
PFD3_YEASTPAC10genetic
20959818
RAD52_YEASTRAD52genetic
21764775
LIF1_YEASTLIF1genetic
23417015
SMT3_YEASTSMT3genetic
23417015
SIZ1_YEASTSIZ1genetic
23417015
RAP1_YEASTRAP1genetic
23417015
SIR4_YEASTSIR4genetic
23417015
RIF2_YEASTRIF2genetic
23417015
SLX5_YEASTSLX5physical
23550137
SLX8_YEASTSLX8physical
23550137
YEN1_YEASTYEN1genetic
25091157
SRS2_YEASTSRS2genetic
25091157
MPH1_YEASTMPH1genetic
25091157
RAD51_YEASTRAD51genetic
25091157
RAD57_YEASTRAD57genetic
25091157
RAD18_YEASTRAD18genetic
25091157
RAD5_YEASTRAD5genetic
25091157
SRS2_YEASTSRS2physical
28341648
SRS2_YEASTSRS2genetic
28341648
RAD5_YEASTRAD5genetic
28341648
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ULS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121 AND SER-209, ANDMASS SPECTROMETRY.

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