| UniProt ID | SIZ1_YEAST | |
|---|---|---|
| UniProt AC | Q04195 | |
| Protein Name | E3 SUMO-protein ligase SIZ1 | |
| Gene Name | SIZ1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 904 | |
| Subcellular Localization | Cytoplasm . Nucleus . Bud neck . Present at the bud neck in early M-phase. | |
| Protein Description | Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA. May be involved in chromosome maintenance.. | |
| Protein Sequence | MINLEDYWEDETPGPDREPTNELRNEVEETITLMELLKVSELKDICRSVSFPVSGRKAVLQDLIRNFLQNALVVGKSDPYRVQAVKFLIERIRKNEPLPVYKDLWNALRKGTPLSAITVRSMEGPPTVQQQSPSVIRQSPTQRRKTSTTSSTSRAPPPTNPDASSSSSSFAVPTIHFKESPFYKIQRLIPELVMNVEVTGGRGMCSAKFKLSKADYNLLSNPNSKHRLYLFSGMINPLGSRGNEPIQFPFPNELRCNNVQIKDNIRGFKSKPGTAKPADLTPHLKPYTQQNNVELIYAFTTKEYKLFGYIVEMITPEQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQCPISYTRMKYPSKSINCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISEFVDDILQNCQKNVEQVELTSDGKWTAILEDDDDSDSDSNDGSRSPEKGTSVSDHHCSSSHPSEPIIINLDSDDDEPNGNNPHVTNNHDDSNRHSNDNNNNSIKNNDSHNKNNNNNNNNNNNNNDNNNSIENNDSNSNNKHDHGSRSNTPSHNHTKNLMNDNDDDDDDRLMAEITSNHLKSTNTDILTEKGSSAPSRTLDPKSYNIVASETTTPVTNRVIPEYLGNSSSYIGKQLPNILGKTPLNVTAVDNSSHLISPDVSVSSPTPRNTASNASSSALSTPPLIRMSSLDPRGSTVPDKTIRPPINSNSYTASISDSFVQPQESSVFPPREQNMDMSFPSTVNSRFNDPRLNTTRFPDSTLRGATILSNNGLDQRNNSLPTTEAITRNDVGRQNSTPVLPTLPQNVPIRTNSNKSGLPLINNENSVPNPPNTATIPLQKSRLIVNPFIPRRPYSNVLPQKRQLSNTSSTSPIMGTWKTQDYGKKYNSG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 127 | Phosphorylation | RSMEGPPTVQQQSPS EECCCCCCCCCCCCC | 33.80 | 22369663 | |
| 132 | Phosphorylation | PPTVQQQSPSVIRQS CCCCCCCCCCHHCCC | 18.14 | 22369663 | |
| 134 | Phosphorylation | TVQQQSPSVIRQSPT CCCCCCCCHHCCCCC | 35.11 | 22369663 | |
| 139 | Phosphorylation | SPSVIRQSPTQRRKT CCCHHCCCCCCCCCC | 21.77 | 22369663 | |
| 141 | Phosphorylation | SVIRQSPTQRRKTST CHHCCCCCCCCCCCC | 39.70 | 21440633 | |
| 147 | Phosphorylation | PTQRRKTSTTSSTSR CCCCCCCCCCCCCCC | 32.49 | 21551504 | |
| 151 | Phosphorylation | RKTSTTSSTSRAPPP CCCCCCCCCCCCCCC | 28.45 | 21551504 | |
| 164 | Phosphorylation | PPTNPDASSSSSSFA CCCCCCCCCCCCCCC | 37.83 | 23749301 | |
| 213 | Ubiquitination | SAKFKLSKADYNLLS EEEEEECHHHHCCCC | 56.57 | 23749301 | |
| 353 | Phosphorylation | EEMGLTTTSTIMSLQ HHCCCCCHHHHHEEE | 20.73 | 27017623 | |
| 436 | Phosphorylation | VEQVELTSDGKWTAI CEEEEECCCCCEEEE | 57.92 | 21440633 | |
| 441 | Phosphorylation | LTSDGKWTAILEDDD ECCCCCEEEEEECCC | 13.80 | 19795423 | |
| 450 | Phosphorylation | ILEDDDDSDSDSNDG EEECCCCCCCCCCCC | 46.11 | 19795423 | |
| 452 | Phosphorylation | EDDDDSDSDSNDGSR ECCCCCCCCCCCCCC | 47.06 | 19795423 | |
| 454 | Phosphorylation | DDDSDSDSNDGSRSP CCCCCCCCCCCCCCC | 40.55 | 19795423 | |
| 458 | Phosphorylation | DSDSNDGSRSPEKGT CCCCCCCCCCCCCCC | 32.23 | 19795423 | |
| 460 | Phosphorylation | DSNDGSRSPEKGTSV CCCCCCCCCCCCCCC | 38.82 | 19795423 | |
| 560 | Phosphorylation | NNKHDHGSRSNTPSH CCCCCCCCCCCCCCC | 29.17 | 27717283 | |
| 562 | Phosphorylation | KHDHGSRSNTPSHNH CCCCCCCCCCCCCCC | 46.91 | 27717283 | |
| 564 | Phosphorylation | DHGSRSNTPSHNHTK CCCCCCCCCCCCCCC | 27.67 | 28889911 | |
| 566 | Phosphorylation | GSRSNTPSHNHTKNL CCCCCCCCCCCCCCC | 34.58 | 27717283 | |
| 590 | Phosphorylation | DRLMAEITSNHLKST HHHHHHHHHHHHHHC | 18.25 | 19779198 | |
| 591 | Phosphorylation | RLMAEITSNHLKSTN HHHHHHHHHHHHHCC | 28.10 | 30377154 | |
| 624 | Phosphorylation | KSYNIVASETTTPVT HHCEEEEECCCCCCC | 25.28 | 22369663 | |
| 626 | Phosphorylation | YNIVASETTTPVTNR CEEEEECCCCCCCCC | 33.21 | 22369663 | |
| 627 | Phosphorylation | NIVASETTTPVTNRV EEEEECCCCCCCCCC | 25.67 | 22369663 | |
| 628 | Phosphorylation | IVASETTTPVTNRVI EEEECCCCCCCCCCC | 24.15 | 22369663 | |
| 648 | Acetylation | NSSSYIGKQLPNILG CCHHHHHHHCCCCCC | 38.82 | 24489116 | |
| 672 | Phosphorylation | DNSSHLISPDVSVSS CCCCCCCCCCCEECC | 22.77 | 23749301 | |
| 676 | Phosphorylation | HLISPDVSVSSPTPR CCCCCCCEECCCCCC | 24.54 | 23749301 | |
| 678 | Phosphorylation | ISPDVSVSSPTPRNT CCCCCEECCCCCCCC | 24.08 | 21440633 | |
| 679 | Phosphorylation | SPDVSVSSPTPRNTA CCCCEECCCCCCCCC | 30.55 | 23749301 | |
| 681 | Phosphorylation | DVSVSSPTPRNTASN CCEECCCCCCCCCCC | 36.51 | 19779198 | |
| 685 | Phosphorylation | SSPTPRNTASNASSS CCCCCCCCCCCCCCC | 32.51 | 27017623 | |
| 690 | Phosphorylation | RNTASNASSSALSTP CCCCCCCCCCCCCCC | 29.13 | 23749301 | |
| 691 | Phosphorylation | NTASNASSSALSTPP CCCCCCCCCCCCCCC | 19.74 | 28889911 | |
| 692 | Phosphorylation | TASNASSSALSTPPL CCCCCCCCCCCCCCE | 30.63 | 23749301 | |
| 696 | Phosphorylation | ASSSALSTPPLIRMS CCCCCCCCCCEEECC | 29.76 | 23749301 | |
| 703 | Phosphorylation | TPPLIRMSSLDPRGS CCCEEECCCCCCCCC | 20.21 | 27017623 | |
| 704 | Phosphorylation | PPLIRMSSLDPRGST CCEEECCCCCCCCCC | 27.70 | 19779198 | |
| 794 | Phosphorylation | GLDQRNNSLPTTEAI CCCCCCCCCCCCCCH | 39.00 | 22369663 | |
| 798 | Phosphorylation | RNNSLPTTEAITRND CCCCCCCCCCHHHCC | 22.83 | 22369663 | |
| 811 | Phosphorylation | NDVGRQNSTPVLPTL CCCCCCCCCCCCCCC | 26.25 | 22369663 | |
| 812 | Phosphorylation | DVGRQNSTPVLPTLP CCCCCCCCCCCCCCC | 25.60 | 19779198 | |
| 817 | Phosphorylation | NSTPVLPTLPQNVPI CCCCCCCCCCCCCCC | 47.08 | 22369663 | |
| 826 | Phosphorylation | PQNVPIRTNSNKSGL CCCCCCCCCCCCCCC | 43.66 | 22369663 | |
| 828 | Phosphorylation | NVPIRTNSNKSGLPL CCCCCCCCCCCCCCC | 45.05 | 22369663 | |
| 880 | Phosphorylation | LPQKRQLSNTSSTSP CCCCCCCCCCCCCCC | 29.71 | 21440633 | |
| 882 | Phosphorylation | QKRQLSNTSSTSPIM CCCCCCCCCCCCCCC | 22.22 | 24961812 | |
| 883 | Phosphorylation | KRQLSNTSSTSPIMG CCCCCCCCCCCCCCC | 35.55 | 24961812 | |
| 884 | Phosphorylation | RQLSNTSSTSPIMGT CCCCCCCCCCCCCCC | 30.76 | 21551504 | |
| 885 | Phosphorylation | QLSNTSSTSPIMGTW CCCCCCCCCCCCCCE | 37.99 | 21440633 | |
| 886 | Phosphorylation | LSNTSSTSPIMGTWK CCCCCCCCCCCCCEE | 17.87 | 25752575 | |
| 891 | Phosphorylation | STSPIMGTWKTQDYG CCCCCCCCEECCCCC | 13.35 | 24961812 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SIZ1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SIZ1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SIZ1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-134; SER-691;THR-696 AND SER-794, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, AND MASSSPECTROMETRY. | |
