HAP1_YEAST - dbPTM
HAP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HAP1_YEAST
UniProt AC P0CE41
Protein Name Heme-responsive zinc finger transcription factor HAP1
Gene Name HAP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1502
Subcellular Localization Nucleus .
Protein Description Regulation of oxygen dependent gene expression. It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c. In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes. Binds to the sequence 5'-CGGNNNTNNCGG-3' (By similarity). Is non-functional in terms of iso-1 cytochrome c expression in strain S288c and its derivatives..
Protein Sequence MSNTPYNSSVPSIASMTQSSVSRSPNMHTATTPGANTSSNSPPLHMSSDSSKIKRKRNRIPLSCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYMEQTWAEEAEKELLKDNELKKLRERVKSLEKTLSKVHSSPSSNSLKSYNTPESSNLFMGSDEHTTLVNANTGSASSASHMHQQQQQQQQQEQQQDFSRSANANANSSSLSISNKYDNDELDLTKDFDLLHIKSNGTIHLGATHWLSIMKGDPYLKLLWGHIFAMREKLNEWYYQKNSYSKLKSSKCPINHAQAPPSAAAAATRKCPVDHSAFSSGMVAPKEETPLPRKCPVDHTMFSSGMIPPREDTSSQKRCPVDHTMYSAGMMPPKDETPSPFSTKAMIDHNKHTMNPPQSKCPVDHRNYMKDYPSDMANSSSNPASRCPIDHSSMKNTAALPASTHNTIPHHQPQSGSHARSHPAQSRKHDSYMTESEVLATLCEMLPPKRVIALFIEKFFKHLYPAIPILDEQNFKNHVNQMLSLSSMNPTVNNFGMSMPSSSTLENQPITQINLPKLSDSCNLGILIIILRLTWLSIPSNSCEVDLGEESGSFLVPNESSNMSASALTSMAKEESLLLKHETPVEALELCQKYLIKFDELSSISNNNVNLTTVQFAIFYNFYMKSASNDLTTLTNTNNTGMANPGHDSESHQILLSNITQMAFSCGLHRDPDNFPQLNATIPATSQDVSNNGSKKANPSTNPTLNNNMSAATTNSSSRSGSADSRSGSNPVNKKENQVSIERFKHTWRKIWYYIVSMDVNQSLSLGSPRLLRNLRDFSDTKLPSASRIDYVRDIKELIIVKNFTLFFQIDLCIIAVLNHILNVSLARSVRKFELDSLINLLKNLTYGTENVNDVVSSLINKGLLPTSEGGSVDSNNDEIYGLPKLPDILNHGQHNQNLYADGRNTSSSDIDKKLDLPHESTTRALFFSKHMTIRMLLYLLNYILFTHYEPMGSEDPGTNILAKEYAQEALNFAMDGYRNCMIFFNNIRNTNSLFDYMNVILSYPCLDIGHRSLQFIVCLILRAKCGPLTGMRESSIITNGTSSGFNSSVEDEDVKVKQESSDELKKDDFMKDVNLDSGDSLAEILMSRMLLFQKLTKQLSKKYNYAIRMNKSTGFFVSLLDTPSKKSDSKSGGSSFMLGNWKHPKVSNMSGFLAGDKDQLQKCPVYQDALGFVSPTGANEGSAPMQGMSLQGSTARMGGTQLPPIRSYKPITYTSSNLRRMNETGEAEAKRRRFNDGYIDNNSNNDIPRGISPKPSNGLSSVQPLLSSFSMNQLNGGTIPTVPSLTNITSQMGALPSLDRITTNQINLPDPSRDEAFDNSIKQMTPMTSAFMNANTTIPSSTLNGNMNMNGAGTANTDTSANGSALSTLTSPQGSDLASNSATQYKPDLEDFLMQNSNFNGLMINPSSLVEVVGGYNDPNNLGRNDAVDFLPVDNVEIDGVGIKINYHLLTSIYVTSILSYTVLEDDANDEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MSNTPYNSSVPSI
--CCCCCCCCCCCCH		26.1528889911
8PhosphorylationMSNTPYNSSVPSIAS
CCCCCCCCCCCCHHH		27.2028889911
9PhosphorylationSNTPYNSSVPSIASM
CCCCCCCCCCCHHHH		34.1228889911
12PhosphorylationPYNSSVPSIASMTQS
CCCCCCCCHHHHCCC		28.7328889911
24PhosphorylationTQSSVSRSPNMHTAT
CCCCCCCCCCCCCCC		17.0823749301
32PhosphorylationPNMHTATTPGANTSS
CCCCCCCCCCCCCCC		19.7723749301
38PhosphorylationTTPGANTSSNSPPLH
CCCCCCCCCCCCCCC		27.5923749301
41PhosphorylationGANTSSNSPPLHMSS
CCCCCCCCCCCCCCC		29.8221440633
48PhosphorylationSPPLHMSSDSSKIKR
CCCCCCCCCCHHHHH		33.6628889911
133PhosphorylationKTLSKVHSSPSSNSL
HHHHHHHCCCCCCCC		47.1028132839
134PhosphorylationTLSKVHSSPSSNSLK
HHHHHHCCCCCCCCC		17.5822369663
136PhosphorylationSKVHSSPSSNSLKSY
HHHHCCCCCCCCCCC		44.0622369663
137PhosphorylationKVHSSPSSNSLKSYN
HHHCCCCCCCCCCCC		33.5522369663
139PhosphorylationHSSPSSNSLKSYNTP
HCCCCCCCCCCCCCC		38.8422369663
201PhosphorylationSANANANSSSLSISN
HHHHCCCCCCCEECC		20.9219779198
202PhosphorylationANANANSSSLSISNK
HHHCCCCCCCEECCC		34.8027017623
203PhosphorylationNANANSSSLSISNKY
HHCCCCCCCEECCCC		26.4219779198
205PhosphorylationNANSSSLSISNKYDN
CCCCCCCEECCCCCC		26.3928889911
280UbiquitinationYSKLKSSKCPINHAQ
HHHHCCCCCCCCCCC		51.6323749301
318PhosphorylationMVAPKEETPLPRKCP
CCCCCCCCCCCCCCC		31.0828889911
366PhosphorylationMMPPKDETPSPFSTK
CCCCCCCCCCCCCCC		38.9227717283
368PhosphorylationPPKDETPSPFSTKAM
CCCCCCCCCCCCCHH		46.1027717283
371PhosphorylationDETPSPFSTKAMIDH
CCCCCCCCCCHHCCC		32.1727717283
372PhosphorylationETPSPFSTKAMIDHN
CCCCCCCCCHHCCCC		24.1727717283
382PhosphorylationMIDHNKHTMNPPQSK
HCCCCCCCCCCCCCC		21.9127017623
399UbiquitinationVDHRNYMKDYPSDMA
CCCCHHHCCCCHHHC		43.6923749301
409PhosphorylationPSDMANSSSNPASRC
CHHHCCCCCCCHHHC		33.6627017623
421PhosphorylationSRCPIDHSSMKNTAA
HHCCCCHHHCCCCCC		28.5127017623
422PhosphorylationRCPIDHSSMKNTAAL
HCCCCHHHCCCCCCC		30.2927017623
487UbiquitinationVIALFIEKFFKHLYP
HHHHHHHHHHHHHCC		51.8123749301
725UbiquitinationVSNNGSKKANPSTNP
CCCCCCCCCCCCCCC		55.9123749301
733PhosphorylationANPSTNPTLNNNMSA
CCCCCCCCCCCCCCC		44.1621551504
739PhosphorylationPTLNNNMSAATTNSS
CCCCCCCCCCCCCCC		19.5121551504
742PhosphorylationNNNMSAATTNSSSRS
CCCCCCCCCCCCCCC		26.6521551504
743PhosphorylationNNMSAATTNSSSRSG
CCCCCCCCCCCCCCC		28.5128889911
745PhosphorylationMSAATTNSSSRSGSA
CCCCCCCCCCCCCCC		27.8328889911
746PhosphorylationSAATTNSSSRSGSAD
CCCCCCCCCCCCCCC		31.6627017623
749PhosphorylationTTNSSSRSGSADSRS
CCCCCCCCCCCCCCC		38.7621551504
756PhosphorylationSGSADSRSGSNPVNK
CCCCCCCCCCCCCCC		50.9928889911
758PhosphorylationSADSRSGSNPVNKKE
CCCCCCCCCCCCCCC		38.9321440633
810PhosphorylationNLRDFSDTKLPSASR
HCCCCCCCCCCCCCC		33.0327017623
811UbiquitinationLRDFSDTKLPSASRI
CCCCCCCCCCCCCCC		64.4923749301
936PhosphorylationYADGRNTSSSDIDKK
CCCCCCCCHHHHHHH		31.2427214570
1072PhosphorylationSIITNGTSSGFNSSV
CEEECCCCCCCCCCC		29.8427017623
1073PhosphorylationIITNGTSSGFNSSVE
EEECCCCCCCCCCCC		47.4427214570
1077PhosphorylationGTSSGFNSSVEDEDV
CCCCCCCCCCCCCCC		33.2419779198
1078PhosphorylationTSSGFNSSVEDEDVK
CCCCCCCCCCCCCCC		30.5419779198
1110PhosphorylationVNLDSGDSLAEILMS
CCCCCCCHHHHHHHH		32.7627017623
1124UbiquitinationSRMLLFQKLTKQLSK
HHHHHHHHHHHHHHH		51.2823749301
1165PhosphorylationDSKSGGSSFMLGNWK
CCCCCCCCCCCCCCC		20.2530377154
1180PhosphorylationHPKVSNMSGFLAGDK
CCCHHCCCCCCCCCH		30.5528889911
1242PhosphorylationIRSYKPITYTSSNLR
CCCCCCCEEECCCHH		29.3128889911
1245PhosphorylationYKPITYTSSNLRRMN
CCCCEEECCCHHCCC		13.5530377154
1246PhosphorylationKPITYTSSNLRRMNE
CCCEEECCCHHCCCC		31.8927017623
1282PhosphorylationNDIPRGISPKPSNGL
CCCCCCCCCCCCCCC		29.6927214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HAP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HAP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HAP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRO9_YEASTSRO9physical
11689685
HSP71_YEASTSSA1physical
11689685
HAP1_YEASTHAP1physical
10428861
HSP82_YEASTHSP82physical
12897155
HSP82_YEASTHSP82physical
11751848
HAP1_YEASTHAP1physical
8464899
HAP2_YEASTHAP2genetic
10628845
UPC2_YEASTUPC2genetic
16702413
ECM22_YEASTECM22genetic
16702413
YND1_YEASTYND1genetic
16702413
TPA1_YEASTTPA1genetic
16702413
HDA3_YEASTHDA3genetic
16702413
RPN9_YEASTRPN9genetic
16702413
SSN2_YEASTSSN2genetic
16702413
GDA1_YEASTGDA1genetic
16702413
PUR6_YEASTADE2genetic
19160453
SWC3_YEASTSWC3genetic
27708008
SCS22_YEASTSCS22genetic
27708008
PYC2_YEASTPYC2genetic
27708008
KCC1_YEASTCMK1genetic
27708008
CDC24_YEASTCDC24genetic
27708008
SEC18_YEASTSEC18genetic
27708008
SCC1_YEASTMCD1genetic
27708008
GLE1_YEASTGLE1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
PDC2_YEASTPDC2genetic
27708008
SLU7_YEASTSLU7genetic
27708008
SEC7_YEASTSEC7genetic
27708008
CDC4_YEASTCDC4genetic
27708008
RCC1_YEASTSRM1genetic
27708008
POB3_YEASTPOB3genetic
27708008
SMP3_YEASTSMP3genetic
27708008
GPN2_YEASTGPN2genetic
27708008
SRP54_YEASTSRP54genetic
27708008
PSB5_YEASTPRE2genetic
27708008
BUR1_YEASTSGV1genetic
27708008
BUD14_YEASTBUD14genetic
27708008
PFF1_YEASTPFF1genetic
27708008
YPQ3_YEASTRTC2genetic
27708008
ATG12_YEASTATG12genetic
27708008
ATG9_YEASTATG9genetic
27708008
ADY3_YEASTADY3genetic
27708008
PSP1_YEASTPSP1genetic
27708008
YRB30_YEASTYRB30genetic
27708008
MGA1_YEASTMGA1genetic
27708008
QCR10_YEASTQCR10genetic
27708008
ADY1_YEASTPFS1genetic
27708008
AIR1_YEASTAIR1genetic
27708008
MGA2_YEASTMGA2genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
YL173_YEASTYLR173Wgenetic
27708008
GGPPS_YEASTBTS1genetic
27708008
HAP2_YEASTHAP2genetic
28830930
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HAP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136; SER-137; SER-139;SER-1180 AND SER-1282, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136, AND MASSSPECTROMETRY.

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