| UniProt ID | SEC18_YEAST | |
|---|---|---|
| UniProt AC | P18759 | |
| Protein Name | Vesicular-fusion protein SEC18 | |
| Gene Name | SEC18 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 758 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.. | |
| Protein Sequence | MFKIPGFGKAAANHTPPDMTNMDTRTRHLKVSNCPNNSYALANVAAVSPNDFPNNIYIIIDNLFVFTTRHSNDIPPGTIGFNGNQRTWGGWSLNQDVQAKAFDLFKYSGKQSYLGSIDIDISFRARGKAVSTVFDQDELAKQFVRCYESQIFSPTQYLIMEFQGHFFDLKIRNVQAIDLGDIEPTSAVATGIETKGILTKQTQINFFKGRDGLVNLKSSNSLRPRSNAVIRPDFKFEDLGVGGLDKEFTKIFRRAFASRIFPPSVIEKLGISHVKGLLLYGPPGTGKTLIARKIGTMLNAKEPKIVNGPEILSKYVGSSEENIRNLFKDAEAEYRAKGEESSLHIIIFDELDSVFKQRGSRGDGTGVGDNVVNQLLAKMDGVDQLNNILVIGMTNRKDLIDSALLRPGRFEVQVEIHLPDEKGRLQIFDIQTKKMRENNMMSDDVNLAELAALTKNFSGAEIEGLVKSASSFAINKTVNIGKGATKLNTKDIAKLKVTREDFLNALNDVTPAFGISEEDLKTCVEGGMMLYSERVNSILKNGARYVRQVRESDKSRLVSLLIHGPAGSGKTALAAEIALKSGFPFIRLISPNELSGMSESAKIAYIDNTFRDAYKSPLNILVIDSLETLVDWVPIGPRFSNNILQMLKVALKRKPPQDRRLLIMTTTSAYSVLQQMDILSCFDNEIAVPNMTNLDELNNVMIESNFLDDAGRVKVINELSRSCPNFNVGIKKTLTNIETARHDEDPVNELVELMTQSA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | GKAAANHTPPDMTNM CHHHCCCCCCCCCCC | 36.00 | 22369663 | |
| 20 | Phosphorylation | NHTPPDMTNMDTRTR CCCCCCCCCCCCCCC | 34.47 | 27017623 | |
| 24 | Phosphorylation | PDMTNMDTRTRHLKV CCCCCCCCCCCEEEE | 24.15 | 27017623 | |
| 106 | Acetylation | AKAFDLFKYSGKQSY HHHHHHHEECCCCCC | 45.89 | 24489116 | |
| 128 | Acetylation | ISFRARGKAVSTVFD EEEECCCCEEEEECC | 39.81 | 24489116 | |
| 131 | Phosphorylation | RARGKAVSTVFDQDE ECCCCEEEEECCHHH | 24.58 | 28152593 | |
| 132 | Phosphorylation | ARGKAVSTVFDQDEL CCCCEEEEECCHHHH | 20.70 | 24961812 | |
| 141 | Acetylation | FDQDELAKQFVRCYE CCHHHHHHHHHHHHH | 57.82 | 24489116 | |
| 185 | Phosphorylation | DLGDIEPTSAVATGI ECCCCCCCCHHCCCC | 19.27 | 24961812 | |
| 186 | Phosphorylation | LGDIEPTSAVATGIE CCCCCCCCHHCCCCE | 31.31 | 24961812 | |
| 195 | Ubiquitination | VATGIETKGILTKQT HCCCCEECCEECCCC | 31.03 | 22817900 | |
| 200 | Ubiquitination | ETKGILTKQTQINFF EECCEECCCCEEEEE | 48.15 | 23749301 | |
| 218 | Phosphorylation | DGLVNLKSSNSLRPR CCCEECCCCCCCCCC | 37.61 | 28889911 | |
| 219 | Phosphorylation | GLVNLKSSNSLRPRS CCEECCCCCCCCCCC | 28.93 | 24961812 | |
| 221 | Phosphorylation | VNLKSSNSLRPRSNA EECCCCCCCCCCCCC | 27.92 | 24961812 | |
| 226 | Phosphorylation | SNSLRPRSNAVIRPD CCCCCCCCCCEECCC | 31.65 | 22369663 | |
| 235 | Ubiquitination | AVIRPDFKFEDLGVG CEECCCCCHHHCCCC | 56.05 | 17644757 | |
| 246 | Acetylation | LGVGGLDKEFTKIFR CCCCCCCHHHHHHHH | 60.82 | 24489116 | |
| 246 | Ubiquitination | LGVGGLDKEFTKIFR CCCCCCCHHHHHHHH | 60.82 | 17644757 | |
| 250 | Ubiquitination | GLDKEFTKIFRRAFA CCCHHHHHHHHHHHH | 45.21 | 17644757 | |
| 268 | Acetylation | FPPSVIEKLGISHVK CCHHHHHHHCCCEEE | 40.67 | 24489116 | |
| 275 | Acetylation | KLGISHVKGLLLYGP HHCCCEEEEEEEECC | 38.12 | 24489116 | |
| 275 | Ubiquitination | KLGISHVKGLLLYGP HHCCCEEEEEEEECC | 38.12 | 17644757 | |
| 287 | Ubiquitination | YGPPGTGKTLIARKI ECCCCCCHHHHHHHH | 39.74 | 17644757 | |
| 296 | Phosphorylation | LIARKIGTMLNAKEP HHHHHHHHCCCCCCC | 23.20 | 21126336 | |
| 314 | Acetylation | NGPEILSKYVGSSEE CCHHHHHHHCCCCHH | 40.27 | 24489116 | |
| 319 | Phosphorylation | LSKYVGSSEENIRNL HHHHCCCCHHHHHHH | 42.89 | 27214570 | |
| 328 | Acetylation | ENIRNLFKDAEAEYR HHHHHHHHHHHHHHH | 60.23 | 24489116 | |
| 432 | Phosphorylation | LQIFDIQTKKMRENN EEEEECCCHHHHHCC | 32.73 | 19795423 | |
| 470 | Phosphorylation | EGLVKSASSFAINKT HHHHHHHHHCEEECE | 32.83 | 21440633 | |
| 521 | Ubiquitination | GISEEDLKTCVEGGM CCCHHHHHHHHHHCE | 52.80 | 17644757 | |
| 552 | Phosphorylation | YVRQVRESDKSRLVS HHHHHHHCCHHHEEE | 39.51 | 28889911 | |
| 648 | Acetylation | NNILQMLKVALKRKP HHHHHHHHHHHHCCC | 21.81 | 24489116 | |
| 714 | Ubiquitination | LDDAGRVKVINELSR CCCCCHHHHHHHHHH | 35.72 | 23749301 | |
| 720 | Phosphorylation | VKVINELSRSCPNFN HHHHHHHHHCCCCCC | 18.90 | 22369663 | |
| 732 | Ubiquitination | NFNVGIKKTLTNIET CCCCCEEHHHHCHHH | 47.01 | 23749301 | |
| 735 | Phosphorylation | VGIKKTLTNIETARH CCEEHHHHCHHHHCC | 39.11 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEC18_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEC18_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEC18_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15; SER-131 AND SER-226,AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15, AND MASSSPECTROMETRY. | |
