| UniProt ID | TIP20_YEAST | |
|---|---|---|
| UniProt AC | P33891 | |
| Protein Name | Protein transport protein TIP20 | |
| Gene Name | TIP20 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 701 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Peripheral membrane protein . |
|
| Protein Description | Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex.. | |
| Protein Sequence | MNGIDDLLNINDRIKQVQNERNELASKLQNLKQSLASNDTEVALSEVIAQDIIEVGASVEGLEQLRAKYGDLQILNKLEKVAVQQTQMQAGVDKLDSFERQLDELAEQPPDQFTLDDVKALHSKLTSVFATVPQINNIDSQYAAYNKLKSKVTGKYNDVIIQRLATNWSNTFDQKLLEAQWDTQKFASTSVGLVKCLRENSTKLYQLSLLYLPLEEETQNGDSERPLSRSNNNQEPVLWNFKSLANNFNVRFTYHFHATSSSSKIETYFQFLNDYLAENLYKCINIFHDDCNGLTKPVIHEQFINYVLQPIRDKVRSTLFQNDLKTLIVLISQILATDKNLLNSFHYHGLGLVSLISDEVWEKWINYEVEMANRQFINITKNPEDFPKSSQNFVKLINKIYDYLEPFYDLDFDLLVRYKLMTCSLIFMNLTSSYLDYILTVDSLNETRTKEQELYQTMAKLQHVNFVYRKIKSLSSNFIFIQLTDIVNSTESKKYNSLFQNVENDYEKAMSTDMQNSIVHRIQKLLKETLRNYFKISTWSTLEMSVDENIGPSSVPSAELVNSINVLRRLINKLDSMDIPLAISLKVKNELLNVIVNYFTESILKLNKFNQNGLNQFLHDFKSLSSILSLPSHATNYKCMSLHELVKILKLKYDPNNQQFLNPEYIKTGNFTSLKEAYSIKYLKDTKIQDALYRIIYGNIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 86 | Phosphorylation | EKVAVQQTQMQAGVD HHHHHHHHHHHHCHH | 14.66 | 29650682 | |
| 94 | Acetylation | QMQAGVDKLDSFERQ HHHHCHHHHHHHHHH | 52.35 | 24489116 | |
| 175 | Acetylation | WSNTFDQKLLEAQWD CCCCCCHHHHHHHHC | 57.81 | 24489116 | |
| 388 | Ubiquitination | KNPEDFPKSSQNFVK CCHHHCCHHHHHHHH | 63.83 | 17644757 | |
| 395 | Ubiquitination | KSSQNFVKLINKIYD HHHHHHHHHHHHHHH | 39.24 | 17644757 | |
| 576 | Phosphorylation | RLINKLDSMDIPLAI HHHHHHHCCCCCEEE | 28.88 | 19823750 | |
| 584 | Phosphorylation | MDIPLAISLKVKNEL CCCCEEEEHHHHHHH | 19.27 | 19795423 | |
| 687 | Acetylation | IKYLKDTKIQDALYR CHHCCCCCHHHHHHH | 48.80 | 24489116 | |
| 693 | Phosphorylation | TKIQDALYRIIYGNI CCHHHHHHHHHHCCC | 11.07 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TIP20_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TIP20_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TIP20_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-693, AND MASSSPECTROMETRY. | |
