| UniProt ID | SEC17_YEAST | |
|---|---|---|
| UniProt AC | P32602 | |
| Protein Name | Alpha-soluble NSF attachment protein | |
| Gene Name | SEC17 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 292 | |
| Subcellular Localization |
Membrane Peripheral membrane protein. |
|
| Protein Description | SNARE complex protein that binds to cis-SNARE complexes on membranes and is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus and for homotypic vacuole fusion. During the priming step of membrane fusion, is released from cis-SNARE complexes by SEC18 to establish a pool of unpaired SNAREs, which are required for interactions in trans during docking and fusion steps. Can displace HOPS from SNARE complexes, which may be a prerequisite for trans-SNARE complex disassembly and subsequent rounds of priming, docking and fusion.. | |
| Protein Sequence | MSDPVELLKRAEKKGVPSSGFMKLFSGSDSYKFEEAADLCVQAATIYRLRKELNLAGDSFLKAADYQKKAGNEDEAGNTYVEAYKCFKSGGNSVNAVDSLENAIQIFTHRGQFRRGANFKFELGEILENDLHDYAKAIDCYELAGEWYAQDQSVALSNKCFIKCADLKALDGQYIEASDIYSKLIKSSMGNRLSQWSLKDYFLKKGLCQLAATDAVAAARTLQEGQSEDPNFADSRESNFLKSLIDAVNEGDSEQLSEHCKEFDNFMRLDKWKITILNKIKESIQQQEDDLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSDPVELLK ------CCCHHHHHH | 51.09 | 22814378 | |
| 19 | Phosphorylation | EKKGVPSSGFMKLFS HHCCCCCCCCHHHHC | 29.94 | 21440633 | |
| 59 | Phosphorylation | ELNLAGDSFLKAADY HHHCCCCHHHHHHHH | 31.40 | 30377154 | |
| 62 | Acetylation | LAGDSFLKAADYQKK CCCCHHHHHHHHHHH | 39.25 | 24489116 | |
| 182 | Phosphorylation | IEASDIYSKLIKSSM EEHHHHHHHHHHHHC | 22.71 | 28889911 | |
| 183 | Ubiquitination | EASDIYSKLIKSSMG EHHHHHHHHHHHHCC | 36.94 | 22817900 | |
| 183 | Acetylation | EASDIYSKLIKSSMG EHHHHHHHHHHHHCC | 36.94 | 24489116 | |
| 186 | Ubiquitination | DIYSKLIKSSMGNRL HHHHHHHHHHCCCCH | 47.08 | 23749301 | |
| 261 | Ubiquitination | EQLSEHCKEFDNFMR HHHHHHHHHHHHHHH | 64.42 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEC17_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEC17_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEC17_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182, AND MASSSPECTROMETRY. | |
