SYYC_YEAST - dbPTM
SYYC_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYYC_YEAST
UniProt AC P36421
Protein Name Tyrosine--tRNA ligase, cytoplasmic
Gene Name TYS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 394
Subcellular Localization Cytoplasm. Nucleus. Predominantly cytoplasmic, only a small fraction (about 1.5%) found in the nucleus.
Protein Description Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two-step reaction: L-tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36. Also involved in nuclear tRNA export. Also attaches D-Tyr to tRNA(Tyr), this reaction is about 150-fold less efficient than attachment of L-Tyr. [PubMed: 10766779]
Protein Sequence MSSAATVDPNEAFGLITKNLQEVLNPQIIKDVLEVQKRHLKLYWGTAPTGRPHCGYFVPMTKLADFLKAGCEVTVLLADLHAFLDNMKAPLEVVNYRAKYYELTIKAILRSINVPIEKLKFVVGSSYQLTPDYTMDIFRLSNIVSQNDAKRAGADVVKQVANPLLSGLIYPLMQALDEQFLDVDCQFGGVDQRKIFVLAEENLPSLGYKKRAHLMNPMVPGLAQGGKMSASDPNSKIDLLEEPKQVKKKINSAFCSPGNVEENGLLSFVQYVIAPIQELKFGTNHFEFFIDRPEKFGGPITYKSFEEMKLAFKEEKLSPPDLKIGVADAINELLEPIRQEFANNKEFQEASEKGYPVATPQKSKKAKKPKNKGTKYPGATKTNEIATKLEETKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSAATVDP
------CCCCCCCCH		28.7828152593
2Acetylation------MSSAATVDP
------CCCCCCCCH		28.78-
3Phosphorylation-----MSSAATVDPN
-----CCCCCCCCHH		22.1819823750
6Phosphorylation--MSSAATVDPNEAF
--CCCCCCCCHHHHH		25.7619823750
30AcetylationVLNPQIIKDVLEVQK
HHCHHHHHHHHHHHH		43.3324489116
37AcetylationKDVLEVQKRHLKLYW
HHHHHHHHHHHEEEE		47.1424489116
99AcetylationEVVNYRAKYYELTIK
HHHHHHHHHHHHHHH		39.0924489116
1182-HydroxyisobutyrylationSINVPIEKLKFVVGS
HCCCCHHHCEEEECC		58.66-
118AcetylationSINVPIEKLKFVVGS
HCCCCHHHCEEEECC		58.6624489116
150AcetylationIVSQNDAKRAGADVV
CCCHHHHHHHCHHHH		45.7225381059
150UbiquitinationIVSQNDAKRAGADVV
CCCHHHHHHHCHHHH		45.7223749301
150SuccinylationIVSQNDAKRAGADVV
CCCHHHHHHHCHHHH		45.7223954790
194UbiquitinationFGGVDQRKIFVLAEE
CCCCCHHHEEEEEEC		34.5623749301
209SuccinylationNLPSLGYKKRAHLMN
CCCCCCCCCCHHHCC		33.7023954790
209AcetylationNLPSLGYKKRAHLMN
CCCCCCCCCCHHHCC		33.7024489116
229PhosphorylationLAQGGKMSASDPNSK
HHHCCCCCCCCCCCC		28.2721440633
231PhosphorylationQGGKMSASDPNSKID
HCCCCCCCCCCCCCC		46.4222369663
235PhosphorylationMSASDPNSKIDLLEE
CCCCCCCCCCCCCCC		36.0522369663
236SuccinylationSASDPNSKIDLLEEP
CCCCCCCCCCCCCCH		47.0523954790
236AcetylationSASDPNSKIDLLEEP
CCCCCCCCCCCCCCH		47.0524489116
244AcetylationIDLLEEPKQVKKKIN
CCCCCCHHHHHHHHH		71.6324489116
247AcetylationLEEPKQVKKKINSAF
CCCHHHHHHHHHHCC		45.9424489116
295AcetylationFFIDRPEKFGGPITY
EECCCHHHHCCCCEE		52.5824489116
295UbiquitinationFFIDRPEKFGGPITY
EECCCHHHHCCCCEE		52.5823749301
303AcetylationFGGPITYKSFEEMKL
HCCCCEECCHHHHHH		39.7624489116
303SuccinylationFGGPITYKSFEEMKL
HCCCCEECCHHHHHH		39.7623954790
309AcetylationYKSFEEMKLAFKEEK
ECCHHHHHHHHHHHH		39.6924489116
313UbiquitinationEEMKLAFKEEKLSPP
HHHHHHHHHHHCCCC		60.4023749301
313AcetylationEEMKLAFKEEKLSPP
HHHHHHHHHHHCCCC		60.4025381059
316AcetylationKLAFKEEKLSPPDLK
HHHHHHHHCCCCCHH		56.1924489116
318PhosphorylationAFKEEKLSPPDLKIG
HHHHHHCCCCCHHHH		45.5121440633
353AcetylationEFQEASEKGYPVATP
HHHHHHHCCCCCCCC		62.3424489116
353UbiquitinationEFQEASEKGYPVATP
HHHHHHHCCCCCCCC		62.3423749301
353SuccinylationEFQEASEKGYPVATP
HHHHHHHCCCCCCCC		62.3423954790
359PhosphorylationEKGYPVATPQKSKKA
HCCCCCCCCCCCCCC		26.8722369663
363PhosphorylationPVATPQKSKKAKKPK
CCCCCCCCCCCCCCC		33.8521440633
372AcetylationKAKKPKNKGTKYPGA
CCCCCCCCCCCCCCC		74.2625381059
375AcetylationKPKNKGTKYPGATKT
CCCCCCCCCCCCCHH		59.1024489116
381AcetylationTKYPGATKTNEIATK
CCCCCCCHHHHHHHH		49.1425381059
388AcetylationKTNEIATKLEETKL-
HHHHHHHHHHHHCC-		44.9024489116
392PhosphorylationIATKLEETKL-----
HHHHHHHHCC-----		28.4224909858
393AcetylationATKLEETKL------
HHHHHHHCC------		56.3224489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYYC_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYYC_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYYC_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SMI1_YEASTSMI1physical
11410349
MVD1_YEASTMVD1physical
16554755
PLPHP_YEASTYBL036Cphysical
16554755
RT10_YEASTRSM10physical
16554755
TSA2_YEASTTSA2physical
16554755
FRA1_YEASTFRA1physical
16554755
RT08_YEASTMRPS8physical
16554755
SYC_YEASTYNL247Wphysical
16554755
RT18_YEASTMRPS18physical
16554755
RT16_YEASTMRPS16physical
11283351
UTP8_YEASTUTP8physical
17634288
MDM10_YEASTMDM10genetic
20093466
YAJ9_YEASTYAR029Wgenetic
20093466
MUM2_YEASTMUM2genetic
20093466
STE50_YEASTSTE50genetic
20093466
ELO2_YEASTELO2genetic
20093466
THRC_YEASTTHR4genetic
20093466
ABP1_YEASTABP1genetic
20093466
FIG2_YEASTFIG2genetic
20093466
CRD1_YEASTCRD1genetic
20093466
RPN4_YEASTRPN4genetic
20093466
RAD57_YEASTRAD57genetic
20093466
OCA6_YEASTOCA6genetic
20093466
DOS2_YEASTDOS2genetic
20093466
ARO1_YEASTARO1genetic
20093466
SAC3_YEASTSAC3genetic
20093466
DHSD_YEASTSDH4genetic
20093466
UME6_YEASTUME6genetic
20093466
PEX10_YEASTPEX10genetic
20093466
STP1_YEASTSTP1genetic
20093466
EMI1_YEASTEMI1genetic
20093466
GET2_YEASTGET2genetic
20093466
IES1_YEASTIES1genetic
20093466
RTF1_YEASTRTF1genetic
20093466
PEX14_YEASTPEX14genetic
20093466
AROC_YEASTARO2genetic
20093466
AAKG_YEASTSNF4genetic
20093466
SSBP1_YEASTSBP1genetic
20093466
NPR3_YEASTNPR3genetic
20093466
SODM_YEASTSOD2genetic
20093466
RRM3_YEASTRRM3genetic
20093466
RPN10_YEASTRPN10genetic
20093466
FLX1_YEASTFLX1genetic
20093466
SDP1_YEASTSDP1genetic
20093466
VID28_YEASTVID28genetic
20093466
URM1_YEASTURM1genetic
20093466
ASF1_YEASTASF1genetic
20093466
SNX4_YEASTSNX4genetic
20093466
DPOD3_YEASTPOL32genetic
20093466
PLMT_YEASTOPI3genetic
20093466
SAC1_YEASTSAC1genetic
20093466
XPOT_YEASTLOS1genetic
20093466
PEX1_YEASTPEX1genetic
20093466
DCOR_YEASTSPE1genetic
20093466
APE2_YEASTAPE2genetic
20093466
MDM35_YEASTMDM35genetic
20093466
UBR2_YEASTUBR2genetic
20093466
PER33_YEASTPER33genetic
20093466
FMP25_YEASTFMP25genetic
20093466
UPS2_YEASTUPS2genetic
20093466
UPS1_YEASTUPS1genetic
20093466
FKS1_YEASTFKS1genetic
20093466
ATP10_YEASTATP10genetic
20093466
PHO84_YEASTPHO84genetic
20093466
GSF2_YEASTGSF2genetic
20093466
MUB1_YEASTMUB1genetic
20093466
TMA23_YEASTTMA23genetic
20093466
NGL2_YEASTNGL2genetic
20093466
EAF7_YEASTEAF7genetic
20093466
EOS1_YEASTEOS1genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
OCA2_YEASTOCA2genetic
20093466
SIW14_YEASTSIW14genetic
20093466
VPS27_YEASTVPS27genetic
20093466
SDHF2_YEASTSDH5genetic
20093466
GSHB_YEASTGSH2genetic
20093466
PEX15_YEASTPEX15genetic
20093466
PHO80_YEASTPHO80genetic
20093466
TOM6_YEASTTOM6genetic
20093466
PUS7_YEASTPUS7genetic
20093466
MDL2_YEASTMDL2genetic
20093466
FUMH_YEASTFUM1genetic
20093466
NEW1_YEASTNEW1genetic
20093466
RU2A_YEASTLEA1genetic
20093466
RTC6_YEASTRTC6genetic
20093466
PPQ1_YEASTPPQ1genetic
20093466
NIP80_YEASTNIP100genetic
20093466
NACB1_YEASTEGD1genetic
20093466
NAA30_YEASTMAK3genetic
20093466
CHMU_YEASTARO7genetic
20093466
UBA3_YEASTUBA3genetic
20093466
UTP22_YEASTUTP22physical
23194188
NAB3_YEASTNAB3genetic
27708008
STU1_YEASTSTU1genetic
27708008
IPYR_YEASTIPP1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
GPI19_YEASTGPI19genetic
27708008
SCC4_YEASTSCC4genetic
27708008
COPB2_YEASTSEC27genetic
27708008
FDFT_YEASTERG9genetic
27708008
KTHY_YEASTCDC8genetic
27708008
CDC91_YEASTGAB1genetic
27708008
RNA1_YEASTRNA1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
SMC5_YEASTSMC5genetic
27708008
SYA_YEASTALA1genetic
27708008
COPZ_YEASTRET3genetic
27708008
TIM50_YEASTTIM50genetic
27708008
NU170_YEASTNUP170genetic
27708008
MUM2_YEASTMUM2genetic
27708008
STE50_YEASTSTE50genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
AIM11_YEASTAIM11genetic
27708008
MRM2_YEASTMRM2genetic
27708008
RPN10_YEASTRPN10genetic
27708008
ICE2_YEASTICE2genetic
27708008
ATG32_YEASTATG32genetic
27708008
VPS53_YEASTVPS53genetic
27708008
ILM1_YEASTILM1genetic
27708008
MRT4_YEASTMRT4genetic
27708008
XPOT_YEASTLOS1genetic
27708008
SRL3_YEASTSRL3genetic
27708008
UBR2_YEASTUBR2genetic
27708008
CSF1_YEASTCSF1genetic
27708008
ELO3_YEASTELO3genetic
27708008
MUB1_YEASTMUB1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
KPR5_YEASTPRS5genetic
27708008
MSB4_YEASTMSB4genetic
27708008
PUS7_YEASTPUS7genetic
27708008
PMA2_YEASTPMA2genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
NEW1_YEASTNEW1genetic
27708008
CHMU_YEASTARO7genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYYC_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235 AND THR-359, ANDMASS SPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-359, AND MASSSPECTROMETRY.

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