| UniProt ID | PLPHP_YEAST | |
|---|---|---|
| UniProt AC | P38197 | |
| Protein Name | Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225} | |
| Gene Name | YBL036C | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 257 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.. | |
| Protein Sequence | MSTGITYDEDRKTQLIAQYESVREVVNAEAKNVHVNENASKILLLVVSKLKPASDIQILYDHGVREFGENYVQELIEKAKLLPDDIKWHFIGGLQTNKCKDLAKVPNLYSVETIDSLKKAKKLNESRAKFQPDCNPILCNVQINTSHEDQKSGLNNEAEIFEVIDFFLSEECKYIKLNGLMTIGSWNVSHEDSKENRDFATLVEWKKKIDAKFGTSLKLSMGMSADFREAIRQGTAEVRIGTDIFGARPPKNEARII | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSTGITYDE ------CCCCCCCCC | 22814378 | ||
| 2 | Phosphorylation | ------MSTGITYDE ------CCCCCCCCC | 22369663 | ||
| 3 | Phosphorylation | -----MSTGITYDED -----CCCCCCCCCC | 22369663 | ||
| 49 | N6-(pyridoxal phosphate)lysine | ILLLVVSKLKPASDI HHHHHHHCCCCHHHC | - | ||
| 49 | Other | ILLLVVSKLKPASDI HHHHHHHCCCCHHHC | 12499548 | ||
| 80 | Acetylation | QELIEKAKLLPDDIK HHHHHHHCCCCCCCC | 24489116 | ||
| 87 | Acetylation | KLLPDDIKWHFIGGL CCCCCCCCEEECCCC | 24489116 | ||
| 104 | Acetylation | NKCKDLAKVPNLYSV CCCHHHHCCCCCEEH | 24489116 | ||
| 118 | Acetylation | VETIDSLKKAKKLNE HHHHHHHHHHHHHHH | 24489116 | ||
| 182 | Phosphorylation | IKLNGLMTIGSWNVS EEECCEEEEEEEECC | 22369663 | ||
| 185 | Phosphorylation | NGLMTIGSWNVSHED CCEEEEEEEECCCCC | 22369663 | ||
| 189 | Phosphorylation | TIGSWNVSHEDSKEN EEEEEECCCCCCCCC | 22369663 | ||
| 193 | Phosphorylation | WNVSHEDSKENRDFA EECCCCCCCCCCCCH | 22369663 | ||
| 194 | Acetylation | NVSHEDSKENRDFAT ECCCCCCCCCCCCHH | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PLPHP_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PLPHP_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PLPHP_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HXT6_YEAST | HXT6 | physical | 11805837 | |
| KAD2_YEAST | ADK1 | physical | 11805837 | |
| PDC6_YEAST | PDC6 | physical | 11805837 | |
| FET4_YEAST | FET4 | physical | 11805837 | |
| HXT7_YEAST | HXT7 | physical | 11805837 | |
| AVO1_YEAST | AVO1 | physical | 11805837 | |
| SYSC_YEAST | SES1 | physical | 11805837 | |
| STM1_YEAST | STM1 | physical | 16554755 | |
| SKI8_YEAST | SKI8 | genetic | 19547744 | |
| HIR2_YEAST | HIR2 | genetic | 19547744 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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