| UniProt ID | AVO1_YEAST | |
|---|---|---|
| UniProt AC | Q08236 | |
| Protein Name | Target of rapamycin complex 2 subunit AVO1 | |
| Gene Name | AVO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1176 | |
| Subcellular Localization |
Cell membrane Peripheral membrane protein Cytoplasmic side . Vacuole membrane Peripheral membrane protein Cytoplasmic side . |
|
| Protein Description | Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.. | |
| Protein Sequence | MDTVTVLNELRAQFLRVCPEKDQMKRIIKPYIPVDEFNTEQCLDSSIRELYMNSDGVSLLPELESPPVSKDFMENYASLGKMRIMRENEGQKGKANQNLIGAEKTERDEEETRNLQDKSAKNTLIVEENGTLRYNPLNSSASNSLLNDDDHTSGKHHKTSSKEDSYLNSSMEMQKKSSKRSSLPFVRIFKSRRDHSNTSGNKNVMNTTNTRAKSSTLHPPGARHNKKGSKFDMNFDFDENLEEEDDDDDDDEEGDDIHSQFFQLDDDFDAKGSGASPAHKGINGMSNNKNNTYTNNRNSISILDDRESSNGNIGSASRLKSHFPTSQKGKIFLTDNKNDGQKSDSLNANKGIHGDGSSASGNGSVSRDGLTETESNNISDMESYINEKDLDDLNFDTVTSNINKTVSDLGGHESTNDGTAVMNRDSKDSRSNSNEFNAQNRDRITPGSSYGKSLLGSEYSEERYSNNDSSTMESGEMSLDSDMQTNTIPSHSIPMSMQKYGIYHGDDDSTLNNVFDKAVLTMNSSRHPKERRDTVISGKEPTSLTSSNRKFSVSSNLTSTRSPLLRGHGRTSSTASSEHMKAPKVSDSVLHRARKSTLTLKQDHSQPSVPSSVHKSSKEGNILIEKTTDYLVSKPKASQLSNMFNKKKKRTNTNSVDVLEYFSFVCGDKVPNYESMGLEIYIQASKKYKRNSFTTKVRKSSTIFEVIGFALFLYSTEKKPDNFEEDGLTVEDISNPNNFSLKIVDEDGEPFEDNFGKLDRKSTIQSISDSEVVLCKVDDAEKSQNEIETPLPFETGGGLMDASTLDANSSHDTTDGTINQLSFYKPIIGNEDDIDKTNGSKIIDVTVYLYPNVNPKFNYTTISVLVTSHINDILVKYCKMKNMDPNEYALKVLGKNYILDLNDTVLRLDGINKVELISKKDARELHLEKMKPDLKKPVLPTIQSNDLTPLTLEPLNSYLKADAGGAVAAIPENTKVTSKAKKISTKYKLGLAKQHSSSSVASGSVSTAGGLANGNGFFKNKNSSKSSLHGTLQFHNINRSQSTMEHTPDTPNGVGDNFQDLFTGAYHKYKVWRRQQMSFINKHERTLAIDGDYIYIVPPEGRIHWHDNVKTKSLHISQVVLVKKSKRVPEHFKIFVRREGQDDIKRYYFEAVSGQECTEIVTRLQNLLSAYRMNHK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDTVTVLN -------CCHHHHHH | 42.54 | 22814378 | |
| 46 | Phosphorylation | TEQCLDSSIRELYMN HHHHHCHHHHHHHHC | 25.90 | 28889911 | |
| 65 | Phosphorylation | SLLPELESPPVSKDF CCCCCCCCCCCCHHH | 47.32 | 28152593 | |
| 69 | Phosphorylation | ELESPPVSKDFMENY CCCCCCCCHHHHHHH | 32.08 | 30377154 | |
| 78 | Phosphorylation | DFMENYASLGKMRIM HHHHHHHHHHHHHHH | 27.56 | 21440633 | |
| 139 | Phosphorylation | LRYNPLNSSASNSLL EEECCCCCCCCCCCC | 34.66 | 22369663 | |
| 140 | Phosphorylation | RYNPLNSSASNSLLN EECCCCCCCCCCCCC | 34.34 | 22369663 | |
| 142 | Phosphorylation | NPLNSSASNSLLNDD CCCCCCCCCCCCCCC | 28.97 | 22369663 | |
| 144 | Phosphorylation | LNSSASNSLLNDDDH CCCCCCCCCCCCCCC | 31.57 | 22369663 | |
| 152 | Phosphorylation | LLNDDDHTSGKHHKT CCCCCCCCCCCCCCC | 46.28 | 22369663 | |
| 153 | Phosphorylation | LNDDDHTSGKHHKTS CCCCCCCCCCCCCCC | 42.28 | 22369663 | |
| 159 | Phosphorylation | TSGKHHKTSSKEDSY CCCCCCCCCCHHHHH | 33.60 | 21440633 | |
| 160 | Phosphorylation | SGKHHKTSSKEDSYL CCCCCCCCCHHHHHH | 44.19 | 22369663 | |
| 161 | Phosphorylation | GKHHKTSSKEDSYLN CCCCCCCCHHHHHHH | 45.34 | 22369663 | |
| 165 | Phosphorylation | KTSSKEDSYLNSSME CCCCHHHHHHHHHHH | 32.39 | 22369663 | |
| 166 | Phosphorylation | TSSKEDSYLNSSMEM CCCHHHHHHHHHHHH | 23.40 | 22369663 | |
| 169 | Phosphorylation | KEDSYLNSSMEMQKK HHHHHHHHHHHHHHH | 28.59 | 28889911 | |
| 276 | Phosphorylation | DAKGSGASPAHKGIN CCCCCCCCCCCCCCC | 26.58 | 28889911 | |
| 286 | Phosphorylation | HKGINGMSNNKNNTY CCCCCCCCCCCCCCC | 38.35 | 23749301 | |
| 292 | Phosphorylation | MSNNKNNTYTNNRNS CCCCCCCCCCCCCCC | 40.91 | 23749301 | |
| 301 | Phosphorylation | TNNRNSISILDDRES CCCCCCEEEECCCCC | 19.54 | 24961812 | |
| 308 | Phosphorylation | SILDDRESSNGNIGS EEECCCCCCCCCCCC | 29.96 | 22369663 | |
| 309 | Phosphorylation | ILDDRESSNGNIGSA EECCCCCCCCCCCCH | 43.96 | 22369663 | |
| 315 | Phosphorylation | SSNGNIGSASRLKSH CCCCCCCCHHHHHHH | 21.19 | 22369663 | |
| 317 | Phosphorylation | NGNIGSASRLKSHFP CCCCCCHHHHHHHCC | 39.58 | 22369663 | |
| 325 | Phosphorylation | RLKSHFPTSQKGKIF HHHHHCCCCCCCCEE | 42.73 | 24961812 | |
| 326 | Phosphorylation | LKSHFPTSQKGKIFL HHHHCCCCCCCCEEE | 30.08 | 28889911 | |
| 343 | Phosphorylation | NKNDGQKSDSLNANK CCCCCCCCCCCCCCC | 25.25 | 21440633 | |
| 345 | Phosphorylation | NDGQKSDSLNANKGI CCCCCCCCCCCCCCC | 30.52 | 25521595 | |
| 357 | Phosphorylation | KGIHGDGSSASGNGS CCCCCCCCCCCCCCC | 27.72 | 22369663 | |
| 358 | Phosphorylation | GIHGDGSSASGNGSV CCCCCCCCCCCCCCC | 31.80 | 22369663 | |
| 360 | Phosphorylation | HGDGSSASGNGSVSR CCCCCCCCCCCCCCC | 34.44 | 22369663 | |
| 364 | Phosphorylation | SSASGNGSVSRDGLT CCCCCCCCCCCCCCC | 22.40 | 22369663 | |
| 366 | Phosphorylation | ASGNGSVSRDGLTET CCCCCCCCCCCCCCC | 26.76 | 22369663 | |
| 373 | Phosphorylation | SRDGLTETESNNISD CCCCCCCCCCCCHHH | 39.21 | 28889911 | |
| 375 | Phosphorylation | DGLTETESNNISDME CCCCCCCCCCHHHHH | 42.47 | 24961812 | |
| 379 | Phosphorylation | ETESNNISDMESYIN CCCCCCHHHHHHHHC | 32.78 | 28889911 | |
| 383 | Phosphorylation | NNISDMESYINEKDL CCHHHHHHHHCHHHH | 25.36 | 24961812 | |
| 384 | Phosphorylation | NISDMESYINEKDLD CHHHHHHHHCHHHHH | 8.41 | 24961812 | |
| 397 | Phosphorylation | LDDLNFDTVTSNINK HHHCCCCHHHHHCCC | 22.88 | 24961812 | |
| 399 | Phosphorylation | DLNFDTVTSNINKTV HCCCCHHHHHCCCCH | 20.39 | 22369663 | |
| 400 | Phosphorylation | LNFDTVTSNINKTVS CCCCHHHHHCCCCHH | 31.23 | 22369663 | |
| 407 | Phosphorylation | SNINKTVSDLGGHES HHCCCCHHHCCCCCC | 32.14 | 23749301 | |
| 414 | Phosphorylation | SDLGGHESTNDGTAV HHCCCCCCCCCCCCC | 27.17 | 21440633 | |
| 415 | Phosphorylation | DLGGHESTNDGTAVM HCCCCCCCCCCCCCC | 34.05 | 25752575 | |
| 429 | Phosphorylation | MNRDSKDSRSNSNEF CCCCCCCCCCCCCCC | 41.15 | 17563356 | |
| 431 | Phosphorylation | RDSKDSRSNSNEFNA CCCCCCCCCCCCCCH | 48.87 | 22369663 | |
| 433 | Phosphorylation | SKDSRSNSNEFNAQN CCCCCCCCCCCCHHC | 38.70 | 22369663 | |
| 445 | Phosphorylation | AQNRDRITPGSSYGK HHCCCCCCCCCHHHH | 23.61 | 22369663 | |
| 448 | Phosphorylation | RDRITPGSSYGKSLL CCCCCCCCHHHHHHC | 22.91 | 22369663 | |
| 449 | Phosphorylation | DRITPGSSYGKSLLG CCCCCCCHHHHHHCC | 43.76 | 22369663 | |
| 450 | Phosphorylation | RITPGSSYGKSLLGS CCCCCCHHHHHHCCC | 30.21 | 22369663 | |
| 460 | Phosphorylation | SLLGSEYSEERYSNN HHCCCCCCHHHHCCC | 29.00 | 30377154 | |
| 503 | Phosphorylation | SMQKYGIYHGDDDST CHHHHCEECCCCCCH | 8.72 | 24961812 | |
| 509 | Phosphorylation | IYHGDDDSTLNNVFD EECCCCCCHHHHHHH | 41.61 | 21440633 | |
| 510 | Phosphorylation | YHGDDDSTLNNVFDK ECCCCCCHHHHHHHH | 40.26 | 21440633 | |
| 534 | Phosphorylation | HPKERRDTVISGKEP CCCCCCCCEECCCCC | 20.23 | 27717283 | |
| 537 | Phosphorylation | ERRDTVISGKEPTSL CCCCCEECCCCCCCC | 39.20 | 23749301 | |
| 542 | Phosphorylation | VISGKEPTSLTSSNR EECCCCCCCCCCCCC | 37.14 | 21082442 | |
| 543 | Phosphorylation | ISGKEPTSLTSSNRK ECCCCCCCCCCCCCC | 40.12 | 25752575 | |
| 546 | Phosphorylation | KEPTSLTSSNRKFSV CCCCCCCCCCCCEEE | 30.80 | 28889911 | |
| 552 | Phosphorylation | TSSNRKFSVSSNLTS CCCCCCEEECCCCCC | 24.91 | 17330950 | |
| 554 | Phosphorylation | SNRKFSVSSNLTSTR CCCCEEECCCCCCCC | 16.59 | 19684113 | |
| 555 | Phosphorylation | NRKFSVSSNLTSTRS CCCEEECCCCCCCCC | 33.43 | 17330950 | |
| 559 | Phosphorylation | SVSSNLTSTRSPLLR EECCCCCCCCCCCCC | 25.62 | 19779198 | |
| 560 | Phosphorylation | VSSNLTSTRSPLLRG ECCCCCCCCCCCCCC | 29.90 | 19684113 | |
| 572 | Phosphorylation | LRGHGRTSSTASSEH CCCCCCCCCCCCHHH | 25.08 | 28889911 | |
| 573 | Phosphorylation | RGHGRTSSTASSEHM CCCCCCCCCCCHHHC | 27.64 | 19779198 | |
| 574 | Phosphorylation | GHGRTSSTASSEHMK CCCCCCCCCCHHHCC | 30.26 | 23749301 | |
| 576 | Phosphorylation | GRTSSTASSEHMKAP CCCCCCCCHHHCCCC | 36.03 | 23749301 | |
| 577 | Phosphorylation | RTSSTASSEHMKAPK CCCCCCCHHHCCCCC | 29.11 | 30377154 | |
| 586 | Phosphorylation | HMKAPKVSDSVLHRA HCCCCCCCHHHHHHH | 30.23 | 24961812 | |
| 588 | Phosphorylation | KAPKVSDSVLHRARK CCCCCCHHHHHHHHH | 21.05 | 23749301 | |
| 596 | Phosphorylation | VLHRARKSTLTLKQD HHHHHHHCCEEECCC | 24.09 | 24961812 | |
| 597 | Phosphorylation | LHRARKSTLTLKQDH HHHHHHCCEEECCCC | 27.14 | 23749301 | |
| 599 | Phosphorylation | RARKSTLTLKQDHSQ HHHHCCEEECCCCCC | 31.81 | 24961812 | |
| 605 | Phosphorylation | LTLKQDHSQPSVPSS EEECCCCCCCCCCCC | 52.67 | 24961812 | |
| 608 | Phosphorylation | KQDHSQPSVPSSVHK CCCCCCCCCCCCCCC | 38.74 | 24961812 | |
| 638 | Phosphorylation | LVSKPKASQLSNMFN HHCCCCHHHHHHHHC | 37.47 | 21551504 | |
| 675 | Phosphorylation | DKVPNYESMGLEIYI CCCCCCHHCCEEEEE | 14.06 | 28889911 | |
| 700 | Phosphorylation | FTTKVRKSSTIFEVI CCCCCCCHHHHHHHH | 23.34 | 28889911 | |
| 701 | Phosphorylation | TTKVRKSSTIFEVIG CCCCCCHHHHHHHHH | 28.67 | 28889911 | |
| 714 | Phosphorylation | IGFALFLYSTEKKPD HHHHHHHHCCCCCCC | 13.25 | 28889911 | |
| 715 | Phosphorylation | GFALFLYSTEKKPDN HHHHHHHCCCCCCCC | 32.03 | 28889911 | |
| 716 | Phosphorylation | FALFLYSTEKKPDNF HHHHHHCCCCCCCCC | 37.96 | 28889911 | |
| 766 | Phosphorylation | DRKSTIQSISDSEVV CCHHHEEECCCCEEE | 21.87 | 28889911 | |
| 941 | Phosphorylation | LKKPVLPTIQSNDLT CCCCCCCCCCCCCCC | 27.73 | 21440633 | |
| 944 | Phosphorylation | PVLPTIQSNDLTPLT CCCCCCCCCCCCCCC | 28.58 | 21440633 | |
| 948 | Phosphorylation | TIQSNDLTPLTLEPL CCCCCCCCCCCCHHH | 21.08 | 20377248 | |
| 951 | Phosphorylation | SNDLTPLTLEPLNSY CCCCCCCCCHHHHHH | 30.22 | 21551504 | |
| 957 | Phosphorylation | LTLEPLNSYLKADAG CCCHHHHHHHCCCCC | 39.25 | 24961812 | |
| 1002 | Phosphorylation | HSSSSVASGSVSTAG CCCCCCCCCCCCCCC | 29.46 | 21551504 | |
| 1004 | Phosphorylation | SSSVASGSVSTAGGL CCCCCCCCCCCCCCC | 15.48 | 21551504 | |
| 1023 | Phosphorylation | GFFKNKNSSKSSLHG CCCCCCCCCCCCCCE | 40.53 | 19779198 | |
| 1024 | Phosphorylation | FFKNKNSSKSSLHGT CCCCCCCCCCCCCEE | 46.05 | 28889911 | |
| 1027 | Phosphorylation | NKNSSKSSLHGTLQF CCCCCCCCCCEEEEE | 28.28 | 19779198 | |
| 1040 | Phosphorylation | QFHNINRSQSTMEHT EEEECCCCCCEEECC | 24.80 | 19779198 | |
| 1043 | Phosphorylation | NINRSQSTMEHTPDT ECCCCCCEEECCCCC | 20.95 | 19779198 | |
| 1047 | Phosphorylation | SQSTMEHTPDTPNGV CCCEEECCCCCCCCC | 15.00 | 19779198 | |
| 1050 | Phosphorylation | TMEHTPDTPNGVGDN EEECCCCCCCCCCCC | 21.62 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AVO1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AVO1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AVO1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-161; SER-165;SER-309; SER-358; SER-429; SER-431; SER-433; SER-543 AND SER-766, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429; SER-433 ANDTHR-948, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-144 ANDSER-552, AND MASS SPECTROMETRY. | |
