SUR2_YEAST - dbPTM
SUR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SUR2_YEAST
UniProt AC P38992
Protein Name Sphingolipid C4-hydroxylase SUR2
Gene Name SUR2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 349
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin..
Protein Sequence MNVTSNATAAGSFPLAFGLKTSFGFMHYAKAPAINLRPKESLLPEMSDGVLALVAPVVAYWALSGIFHVIDTFHLAEKYRIHPSEEVAKRNKASRMHVFLEVILQHIIQTIVGLIFMHFEPIYMTGFEENAMWKLRADLPRIIPDAAIYYGYMYGMSALKIFAGFLFVDTWQYFLHRLMHMNKTLYKWFHSVHHELYVPYAYGALFNNPVEGFLLDTLGTGIAMTLTHLTHREQIILFTFATMKTVDDHCGYALPLDPFQWLFPNNAVYHDIHHQQFGIKTNFAQPFFTFWDNLFQTNFKGFEEYQKKQRRVTIDKYKEFLQERELEKKEKLKNFKAMNAAENEVKKEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20AcetylationFPLAFGLKTSFGFMH
CCCEECEEEECCCHH		42.3725381059
30AcetylationFGFMHYAKAPAINLR
CCCHHHCCCCCCCCC		47.9725381059
316AcetylationQRRVTIDKYKEFLQE
HHCCCHHHHHHHHHH		55.1424489116
318AcetylationRVTIDKYKEFLQERE
CCCHHHHHHHHHHHH		47.9724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SUR2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SUR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SUR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DS1P1_YEASTLCB3genetic
17057230
LCB4_YEASTLCB4genetic
17057230
ERG6_YEASTERG6genetic
16269340
SSO2_YEASTSSO2genetic
16269340
LCB4_YEASTLCB4genetic
16269340
ERG2_YEASTERG2genetic
16269340
ATC1_YEASTPMR1genetic
16269340
RUD3_YEASTRUD3genetic
16269340
DS1P1_YEASTLCB3genetic
16269340
SSH1_YEASTSSH1genetic
16269340
SEC66_YEASTSEC66genetic
16269340
ATC6_YEASTSPF1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
VPS21_YEASTVPS21genetic
16269340
SAC1_YEASTSAC1genetic
16269340
COG6_YEASTCOG6genetic
16269340
ALG8_YEASTALG8genetic
16269340
KEX2_YEASTKEX2genetic
16269340
COG5_YEASTCOG5genetic
16269340
MTC4_YEASTMTC4genetic
16269340
SYS1_YEASTSYS1genetic
16269340
SHR3_YEASTSHR3genetic
16269340
LAC1_YEASTLAC1genetic
16269340
EMC2_YEASTEMC2genetic
16269340
VAB2_YEASTVAB2genetic
16269340
GET2_YEASTGET2genetic
16269340
YEA4_YEASTYEA4genetic
16269340
TRS20_YEASTTRS20genetic
16269340
IRE1_YEASTIRE1genetic
16269340
YJR1_YEASTYJL171Cgenetic
16269340
PMT2_YEASTPMT2genetic
16269340
SOP4_YEASTSOP4genetic
16269340
GET1_YEASTGET1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
ORM2_YEASTORM2genetic
16269340
SCS7_YEASTSCS7genetic
16269340
PPZ1_YEASTPPZ1physical
18467557
TMEDA_YEASTERV25physical
18467557
ORM2_YEASTORM2physical
18467557
CP51_YEASTERG11physical
18467557
CAB3_YEASTCAB3physical
18467557
FAT1_YEASTFAT1genetic
20093466
RV161_YEASTRVS161genetic
20093466
RIM1_YEASTRIM1genetic
20093466
CSM1_YEASTCSM1genetic
20093466
PP2C1_YEASTPTC1genetic
20093466
MAF1_YEASTMAF1genetic
20093466
ATC1_YEASTPMR1genetic
20093466
MNN11_YEASTMNN11genetic
20093466
DS1P1_YEASTLCB3genetic
20093466
PLMT_YEASTOPI3genetic
20093466
HOC1_YEASTHOC1genetic
20093466
DHOM_YEASTHOM6genetic
20093466
VRP1_YEASTVRP1genetic
20093466
ERG6_YEASTERG6genetic
20093466
SSO2_YEASTSSO2genetic
20093466
VPS27_YEASTVPS27genetic
20093466
PHO80_YEASTPHO80genetic
20093466
BUB3_YEASTBUB3genetic
20093466
SGPL_YEASTDPL1genetic
11102354
PHO88_YEASTPHO88physical
16093310
MKAR_YEASTIFA38physical
16093310
ELO2_YEASTELO2physical
16093310
PSS_YEASTCHO1physical
16093310
YG35_YEASTYGR125Wphysical
16093310
SNL1_YEASTSNL1physical
16093310
YET1_YEASTYET1physical
16093310
SRPB_YEASTSRP102physical
16093310
ELO3_YEASTELO3physical
16093310
GSF2_YEASTGSF2physical
16093310
PFA4_YEASTPFA4physical
16093310
ERP4_YEASTERP4physical
16093310
YP264_YEASTYPL264Cphysical
16093310
TOR2_YEASTTOR2genetic
20526336
SYSM_YEASTDIA4genetic
21623372
ERG2_YEASTERG2genetic
21623372
DS1P1_YEASTLCB3genetic
21623372
CSG2_YEASTCSG2genetic
21623372
KCS1_YEASTKCS1genetic
21623372
ETR1_YEASTETR1genetic
21623372
ERG6_YEASTERG6genetic
21623372
LCB4_YEASTLCB4genetic
22166213
SCS7_YEASTSCS7genetic
9368039
DS1P1_YEASTLCB3genetic
23891562
LIP1_YEASTLIP1genetic
23891562
LEM3_YEASTLEM3genetic
23891562
PMA1_YEASTPMA1genetic
23891562
SLA1_YEASTSLA1genetic
23891562
MNN11_YEASTMNN11genetic
23891562
GUP1_YEASTGUP1genetic
23891562
GAS1_YEASTGAS1genetic
23891562
KRE1_YEASTKRE1genetic
23891562
VAM3_YEASTVAM3genetic
23891562
PLMT_YEASTOPI3genetic
23891562
PSD1_YEASTPSD1genetic
23891562
GET2_YEASTGET2genetic
23891562
RGP1_YEASTRGP1genetic
23891562
RIC1_YEASTRIC1genetic
23891562
VPS1_YEASTVPS1genetic
23891562
VPS17_YEASTVPS17genetic
23891562
SRO7_YEASTSRO7genetic
23891562
ERG26_YEASTERG26genetic
23891562
MSMO_YEASTERG25genetic
23891562
CSG2_YEASTCSG2genetic
23891562
SSO2_YEASTSSO2genetic
23891562
FUI1_YEASTFUI1genetic
23891562
SCS7_YEASTSCS7genetic
24875539
LCB1_YEASTLCB1genetic
25040056
RV161_YEASTRVS161genetic
27708008
DPH7_YEASTRRT2genetic
27708008
RIM1_YEASTRIM1genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
MAF1_YEASTMAF1genetic
27708008
SNF1_YEASTSNF1genetic
27708008
CEM1_YEASTCEM1genetic
27708008
AAKG_YEASTSNF4genetic
27708008
HUR1_YEASTHUR1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
DS1P1_YEASTLCB3genetic
27708008
VID22_YEASTVID22genetic
27708008
ERG6_YEASTERG6genetic
27708008
SSO2_YEASTSSO2genetic
27708008
PHO80_YEASTPHO80genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SUR2_YEAST

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Related Literatures of Post-Translational Modification

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