| UniProt ID | TMEDA_YEAST | |
|---|---|---|
| UniProt AC | P54837 | |
| Protein Name | Endoplasmic reticulum vesicle protein 25 | |
| Gene Name | ERV25 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 211 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein. Golgi apparatus membrane Single-pass type I membrane protein. Recycles between endoplasmic reticulum and Golgi. |
|
| Protein Description | Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Possesses a C-terminal dilysine motif that interacts with COPI coat subunits. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum.. | |
| Protein Sequence | MQVLQLWLTTLISLVVAVQGLHFDIAASTDPEQVCIRDFVTEGQLVVADIHSDGSVGDGQKLNLFVRDSVGNEYRRKRDFAGDVRVAFTAPSSTAFDVCFENQAQYRGRSLSRAIELDIESGAEARDWNKISANEKLKPIEVELRRVEEITDEIVDELTYLKNREERLRDTNESTNRRVRNFSILVIIVLSSLGVWQVNYLKNYFKTKHII | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 69 | Phosphorylation | LNLFVRDSVGNEYRR EEEEEECCCCCHHHC | 22.74 | 19779198 | |
| 136 | Acetylation | NKISANEKLKPIEVE HCCCCCCCCCCEEEE | 62.71 | 24489116 | |
| 138 | Acetylation | ISANEKLKPIEVELR CCCCCCCCCEEEEEE | 55.83 | 24489116 | |
| 162 | Ubiquitination | VDELTYLKNREERLR HHHHHHHHCHHHHHH | 43.47 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TMEDA_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TMEDA_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TMEDA_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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