| UniProt ID | MNL2_YEAST | |
|---|---|---|
| UniProt AC | Q12205 | |
| Protein Name | Putative endoplasmic reticulum mannosidase MNL2 | |
| Gene Name | MNL2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 849 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type II membrane protein . |
|
| Protein Description | Putative mannosidase involved in glycoprotein quality control since it is involved in the targeting of misfolded glycoproteins for ER-associated protein degradation (ERAD).. | |
| Protein Sequence | MSIARLVYSLFRRVRSVLLLFITISLLFYYTFQNEIDILNSYALNDSLPSINNYEHNTEGSSKLDPPDLSSTGSDRIATDKENGNVAVDLSDPATLREKNKYFPLLLKGSSHQIGSNLPISSLLTYKEKYPVLFEYSSPSLTSISQNDVHKIQPAMQLPPDVDMIKQIKDIFMKSWNQEQLLLKSNLRRESTWPIDLIDSLDTLYLCGETKLFQDSVNIIEDFDFRVPPLAMEVIDIPDITTRVLEGLLSAYELSMDKRLLNKAKHVADFILRSFDTPNRIPILKYFWKSDLRNRFPDRTVPSGQLTTMALAFIRLSQLTRLNKYFDAVERVFTTIRQSYNEFDMEFMLPDVVDASGCQLLTQEEIENGAHLKGSSIMKSINENFKFVHCQQLGKFLNPPIDDNSLQEQSQYQAYRINEKTVPILENLFKINDLFQSSYDILDGSSKNANAATMDPSIGSEVEAVDEIIEKRNFKDGTKKDSTKNTVGDKSLIDSQTFLTNSISNIFKFMTFRPMLPKQTENKKFNFLNSILTKSQFMPTTNELDVTIRKSYDVSLYSCRLGGILGLSSRVPHRGGVNTKYILPSSLLEMSEIITESCFMLMEEFDGLLPQKFELDPCTDETNGNCEFNGETKSRMIANGEYETFENDLDVGIKVSNYGKGGNDQKAKRNVLSKDGITETQNIKGDTVGSSKSIAEIDGDEVTQIRRVFTLGKDIKPHITTDDTMGSQWKNHPDWPFWVNKVESRRLLDSNIIESIFYMYRISGEQKWRSMGKQSFGILMQELMELNSGAKGLWQIKEFYENGEKVNNDLPSYWFSRTLKYYLLLFSDGDKVSLDKHILTQGGHIIKKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MSIARLVYSLFRRVR CCHHHHHHHHHHHHH | 28889911 | ||
| 9 | Phosphorylation | SIARLVYSLFRRVRS CHHHHHHHHHHHHHH | 28889911 | ||
| 45 | N-linked_Glycosylation | ILNSYALNDSLPSIN HHHHHHCCCCCCCCC | - | ||
| 79 | Phosphorylation | TGSDRIATDKENGNV CCCCCEEECCCCCCE | 27017623 | ||
| 91 | Phosphorylation | GNVAVDLSDPATLRE CCEEEECCCHHHHHH | 27017623 | ||
| 486 | Phosphorylation | KKDSTKNTVGDKSLI CCCCCCCCCCCHHHH | 27017623 | ||
| 497 | Phosphorylation | KSLIDSQTFLTNSIS HHHHHCHHHHHHHHH | 28889911 | ||
| 500 | Phosphorylation | IDSQTFLTNSISNIF HHCHHHHHHHHHHHH | 28889911 | ||
| 673 | Phosphorylation | KAKRNVLSKDGITET HHHHHHCCCCCCCCC | 15665377 | ||
| 693 | Phosphorylation | DTVGSSKSIAEIDGD CCCCCCCCEEECCCC | 25533186 | ||
| 720 | Phosphorylation | KDIKPHITTDDTMGS CCCCCCCCCCCCCCC | 27017623 | ||
| 724 | Phosphorylation | PHITTDDTMGSQWKN CCCCCCCCCCCCCCC | 27017623 | ||
| 727 | Phosphorylation | TTDDTMGSQWKNHPD CCCCCCCCCCCCCCC | 27017623 | ||
| 800 | Phosphorylation | LWQIKEFYENGEKVN CHHHHHHHHCCCCCC | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MNL2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MNL2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MNL2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
