| UniProt ID | PMT1_YEAST | |
|---|---|---|
| UniProt AC | P33775 | |
| Protein Name | Dolichyl-phosphate-mannose--protein mannosyltransferase 1 {ECO:0000305} | |
| Gene Name | PMT1 {ECO:0000303|PubMed:8367478} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 817 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT3 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export. Required for incorporation of proteins in the cell wall.. | |
| Protein Sequence | MSEEKTYKRVEQDDPVPELDIKQGPVRPFIVTDPSAELASLRTMVTLKEKLLVACLAVFTAVIRLHGLAWPDSVVFDEVHFGGFASQYIRGTYFMDVHPPLAKMLYAGVASLGGFQGDFDFENIGDSFPSTTPYVLMRFFSASLGALTVILMYMTLRYSGVRMWVALMSAICFAVENSYVTISRYILLDAPLMFFIAAAVYSFKKYEMYPANSLNAYKSLLATGIALGMASSSKWVGLFTVTWVGLLCIWRLWFMIGDLTKSSKSIFKVAFAKLAFLLGVPFALYLVFFYIHFQSLTLDGDGASFFSPEFRSTLKNNKIPQNVVADVGIGSIISLRHLSTMGGYLHSHSHNYPAGSEQQQSTLYPHMDANNDWLLELYNAPGESLTTFQNLTDGTKVRLFHTVTRCRLHSHDHKPPVSESSDWQKEVSCYGYSGFDGDANDDWVVEIDKKNSAPGVAQERVIALDTKFRLRHAMTGCYLFSHEVKLPAWGFEQQEVTCASSGRHDLTLWYVENNSNPLLPEDTKRISYKPASFISKFIESHKKMWHINKNLVEPHVYESQPTSWPFLLRGISYWGENNRNVYLLGNAIVWWAVTAFIGIFGLIVITELFSWQLGKPILKDSKVVNFHVQVIHYLLGFAVHYAPSFLMQRQMFLHHYLPAYYFGILALGHALDIIVSYVFRSKRQMGYAVVITFLAASVYFFKSFSPIIYGTPWTQELCQKSQWLSGWDYNCNTYFSSLEEYKNQTLTKRESQPAATSTVEEITIEGDGPSYEDLMNEDGKKIFKDTEGNELDPEVVKKMLEEEGANILKVEKRAVLE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSEEKTYKR ------CCCHHHHCC | 55.23 | 22814378 | |
| 8 | Ubiquitination | MSEEKTYKRVEQDDP CCCHHHHCCCCCCCC | 56.02 | 17644757 | |
| 22 | Ubiquitination | PVPELDIKQGPVRPF CCCCCCCCCCCCCCE | 49.20 | 17644757 | |
| 390 | N-linked_Glycosylation | ESLTTFQNLTDGTKV CCCCEEECCCCCCEE | 40.49 | - | |
| 414 | Acetylation | RLHSHDHKPPVSESS CCCCCCCCCCCCCCC | 58.01 | 22865919 | |
| 467 | Succinylation | RVIALDTKFRLRHAM HEEEECCHHHHHHHH | 28.31 | 23954790 | |
| 467 | Acetylation | RVIALDTKFRLRHAM HEEEECCHHHHHHHH | 28.31 | 24489116 | |
| 475 | Phosphorylation | FRLRHAMTGCYLFSH HHHHHHHHCCEEEEC | 25.53 | 30377154 | |
| 513 | N-linked_Glycosylation | LTLWYVENNSNPLLP EEEEEEECCCCCCCC | 47.38 | - | |
| 524 | Acetylation | PLLPEDTKRISYKPA CCCCCCCCCCCCCCH | 61.12 | 24489116 | |
| 536 | Acetylation | KPASFISKFIESHKK CCHHHHHHHHHHHHH | 45.61 | 24489116 | |
| 549 | Acetylation | KKMWHINKNLVEPHV HHHEEECCCCCCCCC | 51.56 | 24489116 | |
| 549 | Ubiquitination | KKMWHINKNLVEPHV HHHEEECCCCCCCCC | 51.56 | 17644757 | |
| 743 | N-linked_Glycosylation | SSLEEYKNQTLTKRE HCHHHHHCCCCCCCC | 38.88 | - | |
| 751 | Phosphorylation | QTLTKRESQPAATST CCCCCCCCCCCCCCC | 45.56 | 27017623 | |
| 756 | Phosphorylation | RESQPAATSTVEEIT CCCCCCCCCCEEEEE | 27.34 | 27017623 | |
| 758 | Phosphorylation | SQPAATSTVEEITIE CCCCCCCCEEEEEEE | 27.81 | 27017623 | |
| 763 | Phosphorylation | TSTVEEITIEGDGPS CCCEEEEEEECCCCC | 19.09 | 27017623 | |
| 784 | Acetylation | EDGKKIFKDTEGNEL CCCCCEECCCCCCCC | 68.18 | 24489116 | |
| 797 | Acetylation | ELDPEVVKKMLEEEG CCCHHHHHHHHHHHC | 37.33 | 24489116 | |
| 809 | Acetylation | EEGANILKVEKRAVL HHCCCEEEEEECHHC | 44.55 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PMT1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PMT1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PMT1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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