| UniProt ID | ERO1_YEAST | |
|---|---|---|
| UniProt AC | Q03103 | |
| Protein Name | Endoplasmic oxidoreductin-1 | |
| Gene Name | ERO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 563 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Peripheral membrane protein Lumenal side . |
|
| Protein Description | Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Also able to oxidize directly the PDI related protein MPD2. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI1 and related proteins. Reoxidation of ERO1 probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress.. | |
| Protein Sequence | MRLRTAIATLCLTAFTSATSNNSYIATDQTQNAFNDTHFCKVDRNDHVSPSCNVTFNELNAINENIRDDLSALLKSDFFKYFRLDLYKQCSFWDANDGLCLNRACSVDVVEDWDTLPEYWQPEILGSFNNDTMKEADDSDDECKFLDQLCQTSKKPVDIEDTINYCDVNDFNGKNAVLIDLTANPERFTGYGGKQAGQIWSTIYQDNCFTIGETGESLAKDAFYRLVSGFHASIGTHLSKEYLNTKTGKWEPNLDLFMARIGNFPDRVTNMYFNYAVVAKALWKIQPYLPEFSFCDLVNKEIKNKMDNVISQLDTKIFNEDLVFANDLSLTLKDEFRSRFKNVTKIMDCVQCDRCRLWGKIQTTGYATALKILFEINDADEFTKQHIVGKLTKYELIALLQTFGRLSESIESVNMFEKMYGKRLNGSENRLSSFFQNNFFNILKEAGKSIRYTIENINSTKEGKKKTNNSQSHVFDDLKMPKAEIVPRPSNGTVNKWKKAWNTEVNNVLEAFRFIYRSYLDLPRNIWELSLMKVYKFWNKFIGVADYVSEETREPISYKLDIQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | N-linked_Glycosylation | AFTSATSNNSYIATD HHHHCCCCCCEEECC | 36.79 | - | |
| 35 | N-linked_Glycosylation | DQTQNAFNDTHFCKV CCCCCCCCCCCEEEC | 51.35 | - | |
| 53 | N-linked_Glycosylation | DHVSPSCNVTFNELN CCCCCCCCEEHHHHH | 39.95 | - | |
| 130 | N-linked_Glycosylation | EILGSFNNDTMKEAD HHHHCCCCCCCCCCC | 44.08 | - | |
| 139 | Phosphorylation | TMKEADDSDDECKFL CCCCCCCCCHHHHHH | 47.73 | 27717283 | |
| 249 | Acetylation | YLNTKTGKWEPNLDL HHCCCCCCCCCCHHH | 54.32 | 24489116 | |
| 303 | Ubiquitination | DLVNKEIKNKMDNVI HHCCHHHHHHHHHHH | 52.16 | 17644757 | |
| 305 | Ubiquitination | VNKEIKNKMDNVISQ CCHHHHHHHHHHHHH | 42.50 | 17644757 | |
| 316 | Ubiquitination | VISQLDTKIFNEDLV HHHHHHHHHCCCCCE | 44.99 | 17644757 | |
| 342 | N-linked_Glycosylation | EFRSRFKNVTKIMDC HHHHHCCCHHHHHHH | 43.93 | - | |
| 425 | N-linked_Glycosylation | KMYGKRLNGSENRLS HHHCCCCCCCCCHHH | 56.85 | - | |
| 444 | Ubiquitination | NNFFNILKEAGKSIR HCHHHHHHHHCHHHH | 41.54 | 17644757 | |
| 444 | Acetylation | NNFFNILKEAGKSIR HCHHHHHHHHCHHHH | 41.54 | 24489116 | |
| 458 | N-linked_Glycosylation | RYTIENINSTKEGKK HHHHHCCCCCCCCCC | 56.03 | - | |
| 468 | N-linked_Glycosylation | KEGKKKTNNSQSHVF CCCCCCCCCCCCCCC | 55.85 | - | |
| 479 | Acetylation | SHVFDDLKMPKAEIV CCCCCCCCCCCCEEE | 61.22 | 24489116 | |
| 491 | N-linked_Glycosylation | EIVPRPSNGTVNKWK EEECCCCCCCCCHHH | 53.49 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ERO1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERO1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERO1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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