| UniProt ID | LEU3_YEAST | |
|---|---|---|
| UniProt AC | P04173 | |
| Protein Name | 3-isopropylmalate dehydrogenase | |
| Gene Name | LEU2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 364 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.. | |
| Protein Sequence | MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLPKNKVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEVKKILA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Ubiquitination | ---MSAPKKIVVLPG ---CCCCCEEEECCC | 55.65 | 17644757 | |
| 6 | Ubiquitination | --MSAPKKIVVLPGD --CCCCCEEEECCCC | 39.41 | 17644757 | |
| 25 | Ubiquitination | EITAEAIKVLKAISD HHHHHHHHHHHHHHH | 48.87 | 17644757 | |
| 54 | Phosphorylation | GGAAIDATGVPLPDE CCEEEECCCCCCCHH | 34.66 | 28889911 | |
| 66 | Phosphorylation | PDEALEASKKADAVL CHHHHHHHHHCCEEE | 25.88 | 28889911 | |
| 67 | Ubiquitination | DEALEASKKADAVLL HHHHHHHHHCCEEEE | 60.06 | 17644757 | |
| 68 | Ubiquitination | EALEASKKADAVLLG HHHHHHHHCCEEEEC | 49.34 | 17644757 | |
| 81 | Ubiquitination | LGAVGGPKWGTGSVR ECCCCCCCCCCCCCC | 62.62 | 17644757 | |
| 84 | Phosphorylation | VGGPKWGTGSVRPEQ CCCCCCCCCCCCHHH | 25.76 | 21082442 | |
| 98 | Ubiquitination | QGLLKIRKELQLYAN HCHHHHHHHHHHHHC | 67.27 | 17644757 | |
| 123 | Ubiquitination | LLDLSPIKPQFAKGT CCCCCCCCCCCCCCC | 35.83 | 17644757 | |
| 128 | Ubiquitination | PIKPQFAKGTDFVVV CCCCCCCCCCCEEEE | 64.73 | 17644757 | |
| 226 | Phosphorylation | VQHQLIDSAAMILVK HHHHHHHCCEEECCC | 15.78 | 28889911 | |
| 277 | Ubiquitination | SLASLPDKNTAFGLY HHHHCCCCCCCCCCC | 55.01 | 17644757 | |
| 290 | Phosphorylation | LYEPCHGSAPDLPKN CCCCCCCCCCCCCCC | 16.98 | 28889911 | |
| 296 | Ubiquitination | GSAPDLPKNKVNPIA CCCCCCCCCCCCHHH | 76.36 | 17644757 | |
| 347 | Phosphorylation | GDLGGSNSTTEVGDA CCCCCCCCCCHHHHH | 38.10 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LEU3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LEU3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LEU3_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SSY1_YEAST | SSY1 | genetic | 11788966 | |
| GAP1_YEAST | GAP1 | genetic | 21526172 | |
| LEUC_YEAST | LEU1 | genetic | 21926174 | |
| IF2A_YEAST | SUI2 | genetic | 21919885 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, AND MASSSPECTROMETRY. | |
