SSY1_YEAST - dbPTM
SSY1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SSY1_YEAST
UniProt AC Q03770
Protein Name SPS-sensor component SSY1
Gene Name SSY1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 852
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Amino acid sensor component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Amino-acid permease homolog that seems to interact directly with the extracellular signaling molecules, but has no amino acid transporter activity. May recruit casein kinases YCK1 and YCK2 to hyperphosphorylate and activate downstream component PTR3 in response to amino acid stimulus..
Protein Sequence MSSVNQIYDLFPNKHNIQFTDSHSQEHDTSSSLAKNDTDGTISIPGSIDTGILKSIIEEQGWNDAELYRSSIQNQRFFLTDKYTKKKHLTMEDMLSPEEEQIYQEPIQDFQTYNKRVQREYELRERMEEFFRQNTKNDLHILNEDSLNQQYSPLGPADYVLPLDRYSRMKHIASNFFRKKLGIPRKLKRRSHYNPNAEGHTKGNSSILSSTTDVIDNASYRNIAIDENVDITHKEHAIDEINEQGASGSESVVEGGSLLHDIEKVFNRSRATRKYHIQRKLKVRHIQMLSIGACFSVGLFLTSGKAFSIAGPFGTLLGFGLTGSIILATMLSFTELSTLIPVSSGFSGLASRFVEDAFGFALGWTYWISCMLALPAQVSSSTFYLSYYNNVNISKGVTAGFITLFSAFSIVVNLLDVSIMGEIVYVAGISKVIIAILMVFTMIILNAGHGNDIHEGVGFRYWDSSKSVRNLTYGLYRPTFDLADAGEGSKKGISGPKGRFLATASVMLISTFAFSGVEMTFLASGEAINPRKTIPSATKRTFSIVLISYVFLIFSVGINIYSGDPRLLSYFPGISEKRYEAIIKGTGMDWRLRTNCRGGIDYRQISVGTGYSSPWVVALQNFGLCTFASAFNAILIFFTATAGISSLFSCSRTLYAMSVQRKAPPVFEICSKRGVPYVSVIFSSLFSVIAYIAVDQTAIENFDVLANVSSASTSIIWMGLNLSFLRFYYALKQRKDIISRNDSSYPYKSPFQPYLAIYGLVGCSLFVIFMGYPNFIHHFWSTKAFFSAYGGLMFFFISYTAYKVLGTSKIQRLDQLDMDSGRREMDRTDWTEHSQYLGTYRERAKKLVTWLI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSVNQIYD
------CCCHHHHHH		42.8928152593
82UbiquitinationQRFFLTDKYTKKKHL
HCEEECCCCCCCCCC		49.9724961812
191PhosphorylationPRKLKRRSHYNPNAE
CHHHHCCCCCCCCCC		34.0627214570
201PhosphorylationNPNAEGHTKGNSSIL
CCCCCCCCCCCCCCC		52.0527214570
398PhosphorylationVNISKGVTAGFITLF
CCCCCCCCHHHHHHH		29.7227017623
425PhosphorylationSIMGEIVYVAGISKV
HHHCCHHHHHHHHHH		7.1127017623
739PhosphorylationKQRKDIISRNDSSYP
HHHHCHHCCCCCCCC		25.9327017623
745PhosphorylationISRNDSSYPYKSPFQ
HCCCCCCCCCCCCCH		17.9627017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SSY1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SSY1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SSY1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GNP1_YEASTGNP1genetic
12073087
MUP1_YEASTMUP1genetic
12073087
PTR3_YEASTPTR3genetic
11489133
LEU3_YEASTLEU2genetic
10409731
ASI1_YEASTASI1genetic
11454748
ASI2_YEASTASI2genetic
11454748
ASI3_YEASTASI3genetic
11454748
BRO1_YEASTBRO1genetic
11454748
BUL1_YEASTBUL1genetic
11454748
UBP4_YEASTDOA4genetic
11454748
RSP5_YEASTRSP5genetic
11454748
CYC8_YEASTCYC8genetic
11454748
TUP1_YEASTTUP1genetic
11454748
UBA1_YEASTUBA1genetic
11454748
VPS20_YEASTVPS20genetic
11454748
VPS36_YEASTVPS36genetic
11454748
SSY5_YEASTSSY5genetic
15509782
PTR3_YEASTPTR3physical
17984223
KC11_YEASTYCK1physical
17984223
SSY5_YEASTSSY5physical
17984223
GPB2_YEASTGPB2genetic
20093466
MDM10_YEASTMDM10genetic
20093466
UIP3_YEASTUIP3genetic
20093466
ETR1_YEASTETR1genetic
20093466
BMT2_YEASTBMT2genetic
20093466
KCC4_YEASTKCC4genetic
20093466
ATG15_YEASTATG15genetic
20093466
YCY0_YEASTYCR090Cgenetic
20093466
HOSC_YEASTLYS20genetic
20093466
DLHH_YEASTYDL086Wgenetic
20093466
NDH2_YEASTNDE2genetic
20093466
VAM6_YEASTVAM6genetic
20093466
PP2C1_YEASTPTC1genetic
20093466
NHP10_YEASTNHP10genetic
20093466
RV167_YEASTRVS167genetic
20093466
ACA1_YEASTACA1genetic
20093466
VFA1_YEASTVFA1genetic
20093466
MAG_YEASTMAG1genetic
20093466
DDI1_YEASTDDI1genetic
20093466
PEA2_YEASTPEA2genetic
20093466
GCN20_YEASTGCN20genetic
20093466
PDK2_YEASTPKP2genetic
20093466
PEF1_YEASTPEF1genetic
20093466
ASK10_YEASTASK10genetic
20093466
SNF6_YEASTSNF6genetic
20093466
SLT2_YEASTSLT2genetic
20093466
OSH3_YEASTOSH3genetic
20093466
GGA2_YEASTGGA2genetic
20093466
PEX28_YEASTPEX28genetic
20093466
HOS4_YEASTHOS4genetic
20093466
OPT1_YEASTOPT1genetic
20093466
NUC1_YEASTNUC1genetic
20093466
PHO90_YEASTPHO90genetic
20093466
SET2_YEASTSET2genetic
20093466
RPA34_YEASTRPA34genetic
20093466
BCK1_YEASTBCK1genetic
20093466
MHP1_YEASTMHP1genetic
20093466
VPS55_YEASTVPS55genetic
20093466
2NDP_YEASTYJR149Wgenetic
20093466
MDM35_YEASTMDM35genetic
20093466
RSSA2_YEASTRPS0Bgenetic
20093466
STM1_YEASTSTM1genetic
20093466
CRR1_YEASTCRR1genetic
20093466
SPH1_YEASTSPH1genetic
20093466
MID2_YEASTMID2genetic
20093466
VRP1_YEASTVRP1genetic
20093466
CDC73_YEASTCDC73genetic
20093466
GTR1_YEASTGTR1genetic
20093466
AIM34_YEASTAIM34genetic
20093466
YMP8_YEASTYMR018Wgenetic
20093466
SAM37_YEASTSAM37genetic
20093466
SPG4_YEASTSPG4genetic
20093466
GBLP_YEASTASC1genetic
20093466
TMA23_YEASTTMA23genetic
20093466
VPS27_YEASTVPS27genetic
20093466
BRE5_YEASTBRE5genetic
20093466
TRM11_YEASTTRM11genetic
20093466
EXO1_YEASTEXO1genetic
20093466
SHE4_YEASTSHE4genetic
20093466
CY1_YEASTCYT1genetic
20093466
VPS5_YEASTVPS5genetic
20093466
VAM10_YEASTVAM10genetic
20093466
VAM3_YEASTVAM3genetic
20093466
COQ7_YEASTCAT5genetic
20093466
LIPA_YEASTLIP5genetic
20093466
HRK1_YEASTHRK1genetic
20093466
PALA_YEASTRIM20genetic
20093466
SPS4_YEASTSPS4genetic
20093466
HAP5_YEASTHAP5genetic
20093466
NCBP2_YEASTCBC2genetic
20093466
COX10_YEASTCOX10genetic
20093466
SYH1_YEASTSYH1genetic
20093466
OAZ_YEASTOAZ1genetic
20093466
PMA2_YEASTPMA2genetic
20093466
OPT2_YEASTOPT2genetic
20093466
DIP5_YEASTDIP5genetic
11742997
GAP1_YEASTGAP1genetic
11742997
SSY5_YEASTSSY5genetic
20421414
UBR1_YEASTUBR1genetic
20421414
GAP1_YEASTGAP1genetic
21526172
SSY5_YEASTSSY5physical
23447701
PTR3_YEASTPTR3physical
23447701
SLT2_YEASTSLT2genetic
22282571
HRK1_YEASTHRK1genetic
22282571
BCK1_YEASTBCK1genetic
22282571
SSY5_YEASTSSY5genetic
21653827
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SSY1_YEAST

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Related Literatures of Post-Translational Modification

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