SSY5_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSY5_YEAST
• UniProt AC: P47002
• Protein Name: SPS-sensor serine protease component SSY5
• Gene Name: SSY5
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 699
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1..
• Protein Sequence: MVRFFGLNKKKNEEKENTDLPADNEQNAAETSSSNVSGNEERIDPNSHDTNPENANNDDASTTFGSSIQSSSIFSRGRMTYGTGASSSMATSEMRSHSSGHSGSKNSKNLQGFKDVGKPLRAVSFLSPVKEEESQDTQNTLDVSSSTSSTLATSENARENSFTSRRSITLEYIHKSLSELEENLVDIMDDIHQDVISISKAVIEAIEYFKEFLPTTRDRIPYRISLEKSSSLRKINKIVLHFLDNLLVSDAFSNSRSILLRRFYFFLKKLNLITDDDLISESGVLPCLSVFCIGSHCNLPSMDKLGMILDELTKMDSSIISDQEGAFIAPILRGITPKSSILTIMFGLPNLQHEHYEMIKVLYSLFPDVHMYCVKDYIKKAASAVGSIPSHTAATIDTIAPTKFQFSPPYAVSENPLELPISMSLSTETSAKITGTLGGYLFPQTGSDKKFSQFASCSFAITCAHVVLSEKQDYPNVMVPSNVLQTSYKKVLTKESDRYPDGSVEKTAFLEEVQRIDQNLNWQKSNKFGQVVWGERAIVDHRLSDFAIIKVNSSFKCQNTLGNGLKSFPDPTLRFQNLHVKRKIFKMKPGMKVFKIGASTGYTSGELNSTKLVYWADGKLQSSEFVVASPTPLFASAGDSGAWILTKLEDRLGLGLVGMLHSYDGEQRQFGLFTPIGDILERLHAVTKIQWDIDPQLDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	IFSRGRMTYGTGASS CCCCCEEECCCCCCC	19.89	28889911
86	Phosphorylation	MTYGTGASSSMATSE EECCCCCCCCCCCHH	25.04	27017623
91	Phosphorylation	GASSSMATSEMRSHS CCCCCCCCHHHHHCC	19.31	27017623
102	Phosphorylation	RSHSSGHSGSKNSKN HHCCCCCCCCCCCCC	48.57	27017623
104	Phosphorylation	HSSGHSGSKNSKNLQ CCCCCCCCCCCCCCC	31.51	27017623
105	Ubiquitination	SSGHSGSKNSKNLQG CCCCCCCCCCCCCCC	69.62	22817900
108	Ubiquitination	HSGSKNSKNLQGFKD CCCCCCCCCCCCCCC	71.69	23749301
114	Ubiquitination	SKNLQGFKDVGKPLR CCCCCCCCCCCCCEE	59.33	22817900
118	Ubiquitination	QGFKDVGKPLRAVSF CCCCCCCCCEEEEEC	40.50	22817900
200	Ubiquitination	QDVISISKAVIEAIE HHHHHHHHHHHHHHH	45.03	17644757
210	Ubiquitination	IEAIEYFKEFLPTTR HHHHHHHHHHCCCCC	46.81	23749301
228	Ubiquitination	PYRISLEKSSSLRKI CEEEEECCCCHHHHH	62.01	23749301
449	Ubiquitination	FPQTGSDKKFSQFAS ECCCCCCCCHHHHHH	58.37	22817900
450	Ubiquitination	PQTGSDKKFSQFASC CCCCCCCCHHHHHHC	56.06	22817900
493	Phosphorylation	TSYKKVLTKESDRYP CCHHHHHCCCHHCCC	35.44	28889911
496	Phosphorylation	KKVLTKESDRYPDGS HHHHCCCHHCCCCCC	29.01	28889911
506	Ubiquitination	YPDGSVEKTAFLEEV CCCCCHHHHHHHHHH	42.89	15699485
524	Ubiquitination	DQNLNWQKSNKFGQV HHHCCHHHCCCCCCC	47.84	15699485
527	Ubiquitination	LNWQKSNKFGQVVWG CCHHHCCCCCCCEEE	58.94	15699485
550	Ubiquitination	LSDFAIIKVNSSFKC CCCEEEEEECCCCCC	29.29	15699485
566	Ubiquitination	NTLGNGLKSFPDPTL CCCCCCHHCCCCCCH	51.99	23749301
595	Ubiquitination	KPGMKVFKIGASTGY CCCCEEEEEECCCCC	43.12	15699485
611	Ubiquitination	SGELNSTKLVYWADG CCCCCCCEEEEEECC	35.46	15699485

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SSY5_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSY5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSY5_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MET4_YEAST	MET4	genetic	16977312
MET3_YEAST	MET3	genetic	16977312
UBR1_YEAST	UBR1	genetic	20421414
CDC25_YEAST	CDC25	genetic	25825491
MAOM_YEAST	MAE1	genetic	25825491
OAC1_YEAST	OAC1	genetic	25825491
PPB_YEAST	PHO8	genetic	25825491

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.