MET3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MET3_YEAST
• UniProt AC: P08536
• Protein Name: Sulfate adenylyltransferase {ECO:0000255|HAMAP-Rule:MF_03106}
• Gene Name: MET3 {ECO:0000255|HAMAP-Rule:MF_03106}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 511
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids..
• Protein Sequence: MPAPHGGILQDLIARDALKKNELLSEAQSSDILVWNLTPRQLCDIELILNGGFSPLTGFLNENDYSSVVTDSRLADGTLWTIPITLDVDEAFANQIKPDTRIALFQDDEIPIAILTVQDVYKPNKTIEAEKVFRGDPEHPAISYLFNVAGDYYVGGSLEAIQLPQHYDYPGLRKTPAQLRLEFQSRQWDRVVAFQTRNPMHRAHRELTVRAAREANAKVLIHPVVGLTKPGDIDHHTRVRVYQEIIKRYPNGIAFLSLLPLAMRMSGDREAVWHAIIRKNYGASHFIVGRDHAGPGKNSKGVDFYGPYDAQELVESYKHELDIEVVPFRMVTYLPDEDRYAPIDQIDTTKTRTLNISGTELRRRLRVGGEIPEWFSYPEVVKILRESNPPRPKQGFSIVLGNSLTVSREQLSIALLSTFLQFGGGRYYKIFEHNNKTELLSLIQDFIGSGSGLIIPNQWEDDKDSVVGKQNVYLLDTSSSADIQLESADEPISHIVQKVVLFLEDNGFFVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
126	Phosphorylation	DVYKPNKTIEAEKVF CCCCCCCEEEEEEEC	30.59	15665377
357	Phosphorylation	KTRTLNISGTELRRR CCEEEECCHHHHHHH	38.29	28889911
359	Phosphorylation	RTLNISGTELRRRLR EEEECCHHHHHHHHC	25.67	28152593

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MET3_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MET3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MET3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MET3_YEAST	MET3	physical	11283351
MET3_YEAST	MET3	physical	14983089
THDH_YEAST	ILV1	genetic	21623372
FOLE_YEAST	MET7	genetic	21623372
ARGJ_YEAST	ARG7	genetic	21623372
MET3_YEAST	MET3	physical	22615397
TRS20_YEAST	TRS20	genetic	27708008
APC11_YEAST	APC11	genetic	27708008
SNU23_YEAST	SNU23	genetic	27708008
UAP1_YEAST	QRI1	genetic	27708008
RPB1_YEAST	RPO21	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
TRS23_YEAST	TRS23	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
CDC20_YEAST	CDC20	genetic	27708008
DBF2_YEAST	DBF2	genetic	27708008
PRP21_YEAST	PRP21	genetic	27708008
UGPA1_YEAST	UGP1	genetic	27708008
PRS7_YEAST	RPT1	genetic	27708008
BOS1_YEAST	BOS1	genetic	27708008
AFG2_YEAST	AFG2	genetic	27708008
VTI1_YEAST	VTI1	genetic	27708008
DCP2_YEAST	DCP2	genetic	27708008
PRP2_YEAST	PRP2	genetic	27708008
RPB2_YEAST	RPB2	genetic	27708008
GRPE_YEAST	MGE1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-359, AND MASSSPECTROMETRY.
PubMed: 18407956

"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-126, AND MASSSPECTROMETRY.
PubMed: 15665377