MHP1_YEAST - dbPTM
MHP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MHP1_YEAST
UniProt AC P43638
Protein Name MAP-homologous protein 1
Gene Name MHP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1398
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic microtubules and mitotic spindles.
Protein Description Essential for the formation and/or stabilization of microtubules. Binds to microtubules in vitro..
Protein Sequence MDSKDTQKLLKEHRIPCIDVGWLVRPSASTSKSSRPGKSESKANSVAPDIQMDTARPPVFETSVDSSSSILSSNDKGRRHSVAASLLMDNQRANAGSTSVPTNIPPPRGRSKSVVETNLSNVEADSGHHHHHRHHHHTEDAPAPKKVGFFKSLFGHRKKDQEQQEKERERKERSPSPTHVDRGAAIRRERTATISAESPPPLQYNAPPSYNDTVVPLTRSKTESEVYYENHPQSYYHGRMRTYHSPEEGKVDGTSPADDHNYGGSRPDPRLMDFLRYYKSKDYKLAAFKEGNFIKSSASPTTKKNRRASFSLHNDKPQPAKSLAHQKFDAKGRPIPPHPDAPKLPSAFRKKHPSNASIVDTVDSNSDVSSSAQNNNQTPSSHKFGAFLRKVTSYGNNNNNSTNASSLSANVNNPDTSSTSLWSSSSMEFDPSKITTVPGLENIRPLKHVSFATNTYFNDPPQQICSKNPRKGEVEVKPNGSVVIHRLTPQERKKIMESTSLGVVVGGTGQLKLLNPEEDDANAKSKEEMAPQKQNEVEAHDEEDNNSQRRNIVMAAAEAAAEARAKEAPNELKRIVTNNEEEVTVSKTASHLTIDKPMISRRGASTSSLASMVSSDTNGTNADDEGEILPPPSLKIPHDIVYTRCCHLREILPIPATLKQLKKGSTDPIPILQLRNPRPSMVEIWSFSDFLSIAPVLCLSLDGVQLTVQMLRIILSSLVYKQHFQKLSLRNTPLDEEGWKVLCYFVSKAKSLHSIDLTMVPSIKTNVQKPSKSSLKSKILRMQCNLENRSDMNWDLLTASIALMGGLEEIVISGAKMNSAQFKNFILVACIATERLGLAYNGLSKSQCDDLAKWMVQSKVTGLDVGFNDLNGKLSSFTDAVLGKIQKANEKNVFKFLSLNGTNLRVNEHDTFENNEVLKLISVLCYLENLKFLDISNNPAIFPHCVPTLIDFLPVFVNLVRLHIDYNNLSSTSVVMLAEILPMCSRLNYFSMLGTELDLASSKALAEAVRKSSSLMTLDVDYVYMPENIKEKISLYALRNIQGELKRVNSDDKDIKDSQFSSLQDQLSLLLTEKADNSEHYNKMVENFMAKIALARIKISKVVHDLFDLKLNGQLNLEGKEALIRLCFIEASLERGCDLLKQRHNNTLKSPEAVSKSRKGGNQAQPNSESCQRMLLSSSILQNSDHIALMPFGSAIVEKSSPDAEDAVEFREGDDSNVNHEDVPANDQQFRDEVDIKNKYSIIKRELEHEKLVGGGDLPVDKEILNRAAQSLDSDQIKEFLLKNDVSTILGVIDELHSQGYHLHHIFKKQGNQEETAFRTKDEQQSSQSNDSSANASPTTDPISTGSNTSRTNDNAHIPPTDAPGFDKFMNNAEENAIDAAYDDVLDKIQDARNSSTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDSKDTQK
-------CCHHHHHH		51.8022814378
27PhosphorylationVGWLVRPSASTSKSS
ECEEECCCCCCCCCC		25.0423749301
45PhosphorylationKSESKANSVAPDIQM
CCHHHHCCCCCCCCC		25.2322369663
54PhosphorylationAPDIQMDTARPPVFE
CCCCCCCCCCCCCEE		21.1523749301
62PhosphorylationARPPVFETSVDSSSS
CCCCCEEECCCCCCC		23.6820377248
63PhosphorylationRPPVFETSVDSSSSI
CCCCEEECCCCCCCC		19.4122369663
66PhosphorylationVFETSVDSSSSILSS
CEEECCCCCCCCCCC		29.9322369663
67PhosphorylationFETSVDSSSSILSSN
EEECCCCCCCCCCCC		24.5222369663
68PhosphorylationETSVDSSSSILSSND
EECCCCCCCCCCCCC		25.9120377248
69PhosphorylationTSVDSSSSILSSNDK
ECCCCCCCCCCCCCC		29.5120377248
72PhosphorylationDSSSSILSSNDKGRR
CCCCCCCCCCCCCCC		25.9822369663
73PhosphorylationSSSSILSSNDKGRRH
CCCCCCCCCCCCCCH		45.6723749301
76UbiquitinationSILSSNDKGRRHSVA
CCCCCCCCCCCHHHH		59.5822817900
81PhosphorylationNDKGRRHSVAASLLM
CCCCCCHHHHHHHHH		16.1923749301
85PhosphorylationRRHSVAASLLMDNQR
CCHHHHHHHHHCCCC		16.5823749301
111PhosphorylationIPPPRGRSKSVVETN
CCCCCCCCCCCEEEE		31.9123749301
113PhosphorylationPPRGRSKSVVETNLS
CCCCCCCCCEEEECC		32.4223749301
126PhosphorylationLSNVEADSGHHHHHR
CCCCCCCCCCCCCCC		47.2623749301
174PhosphorylationERERKERSPSPTHVD
HHHHHHHCCCCCCHH		30.7121082442
176PhosphorylationERKERSPSPTHVDRG
HHHHHCCCCCCHHHH		43.6121082442
178PhosphorylationKERSPSPTHVDRGAA
HHHCCCCCCHHHHHH		38.5822890988
191PhosphorylationAAIRRERTATISAES
HHHCCEEEEEECCCC		24.3319779198
193PhosphorylationIRRERTATISAESPP
HCCEEEEEECCCCCC		18.1723749301
195PhosphorylationRERTATISAESPPPL
CEEEEEECCCCCCCC		22.9429734811
198PhosphorylationTATISAESPPPLQYN
EEEECCCCCCCCCCC		42.2825752575
220PhosphorylationTVVPLTRSKTESEVY
CEEECCCCCCCCCEE		38.4023749301
221UbiquitinationVVPLTRSKTESEVYY
EEECCCCCCCCCEEE		53.6823749301
222PhosphorylationVPLTRSKTESEVYYE
EECCCCCCCCCEEEC		46.0922369663
224PhosphorylationLTRSKTESEVYYENH
CCCCCCCCCEEECCC		37.2822890988
228PhosphorylationKTESEVYYENHPQSY
CCCCCEEECCCCCCE		18.5422890988
235PhosphorylationYENHPQSYYHGRMRT
ECCCCCCEECCCCCE		8.3422890988
245PhosphorylationGRMRTYHSPEEGKVD
CCCCEECCCCCCCCC		24.4823749301
250AcetylationYHSPEEGKVDGTSPA
ECCCCCCCCCCCCCC		40.1924489116
250UbiquitinationYHSPEEGKVDGTSPA
ECCCCCCCCCCCCCC		40.1922817900
299PhosphorylationNFIKSSASPTTKKNR
CEECCCCCCCCCCCC		25.4028889911
309PhosphorylationTKKNRRASFSLHNDK
CCCCCCCCEECCCCC		17.3522369663
311PhosphorylationKNRRASFSLHNDKPQ
CCCCCCEECCCCCCC		26.6522369663
354PhosphorylationAFRKKHPSNASIVDT
HHHHHCCCCCCCEEE		44.7629136822
357PhosphorylationKKHPSNASIVDTVDS
HHCCCCCCCEEECCC		27.6520377248
361PhosphorylationSNASIVDTVDSNSDV
CCCCCEEECCCCCCC		18.4729136822
364PhosphorylationSIVDTVDSNSDVSSS
CCEEECCCCCCCCCC		33.6220377248
366PhosphorylationVDTVDSNSDVSSSAQ
EEECCCCCCCCCCCC		43.2629136822
369PhosphorylationVDSNSDVSSSAQNNN
CCCCCCCCCCCCCCC		24.4620377248
370PhosphorylationDSNSDVSSSAQNNNQ
CCCCCCCCCCCCCCC		29.5529136822
371PhosphorylationSNSDVSSSAQNNNQT
CCCCCCCCCCCCCCC		26.7721440633
378PhosphorylationSAQNNNQTPSSHKFG
CCCCCCCCCCHHHHH		27.5423749301
380PhosphorylationQNNNQTPSSHKFGAF
CCCCCCCCHHHHHHH		48.7629136822
381PhosphorylationNNNQTPSSHKFGAFL
CCCCCCCHHHHHHHH		31.7220377248
402PhosphorylationGNNNNNSTNASSLSA
CCCCCCCCCHHHCEE		36.6123749301
526UbiquitinationDDANAKSKEEMAPQK
CCCCCCCHHHHCCHH		57.9223749301
577PhosphorylationNELKRIVTNNEEEVT
HHHHHHHHCCCCEEE		29.9225521595
584PhosphorylationTNNEEEVTVSKTASH
HCCCCEEEEEEECCC		23.4922890988
586PhosphorylationNEEEVTVSKTASHLT
CCCEEEEEEECCCCE		18.2222890988
588PhosphorylationEEVTVSKTASHLTID
CEEEEEEECCCCEEC		26.3628889911
590PhosphorylationVTVSKTASHLTIDKP
EEEEEECCCCEECCC		25.0223749301
600PhosphorylationTIDKPMISRRGASTS
EECCCHHCCCCCCHH		15.0720377248
605PhosphorylationMISRRGASTSSLASM
HHCCCCCCHHHHHHH		31.4823749301
607PhosphorylationSRRGASTSSLASMVS
CCCCCCHHHHHHHHC		22.3623749301
608PhosphorylationRRGASTSSLASMVSS
CCCCCHHHHHHHHCC		28.2223749301
611PhosphorylationASTSSLASMVSSDTN
CCHHHHHHHHCCCCC		25.6323749301
614PhosphorylationSSLASMVSSDTNGTN
HHHHHHHCCCCCCCC		17.5423749301
617PhosphorylationASMVSSDTNGTNADD
HHHHCCCCCCCCCCC		37.1823749301
620PhosphorylationVSSDTNGTNADDEGE
HCCCCCCCCCCCCCC		29.3323749301
771PhosphorylationKTNVQKPSKSSLKSK
CCCCCCCCHHHHHHH		52.8123749301
773PhosphorylationNVQKPSKSSLKSKIL
CCCCCCHHHHHHHHH		45.2823749301
774PhosphorylationVQKPSKSSLKSKILR
CCCCCHHHHHHHHHH		43.4826447709
777PhosphorylationPSKSSLKSKILRMQC
CCHHHHHHHHHHHHC		30.1626447709
895AcetylationANEKNVFKFLSLNGT
CCCCCCEEEEECCCC		40.9024489116
1012PhosphorylationLAEAVRKSSSLMTLD
HHHHHHHCCCCCEEC		18.0030377154
1014PhosphorylationEAVRKSSSLMTLDVD
HHHHHCCCCCEECCC		29.2919779198
1017PhosphorylationRKSSSLMTLDVDYVY
HHCCCCCEECCCEEE		25.7119779198
1022PhosphorylationLMTLDVDYVYMPENI
CCEECCCEEECCCCH		8.0430377154
1024PhosphorylationTLDVDYVYMPENIKE
EECCCEEECCCCHHH		10.7530377154
1050PhosphorylationGELKRVNSDDKDIKD
HHHHHCCCCCCCCCH		44.3128889911
1150PhosphorylationRHNNTLKSPEAVSKS
HCCCCCCCHHHHHHC		30.9625704821
1170PhosphorylationQAQPNSESCQRMLLS
CCCCCCHHHHHHHHH		18.5128889911
1178PhosphorylationCQRMLLSSSILQNSD
HHHHHHHHHHHHCCC		22.7423749301
1200PhosphorylationGSAIVEKSSPDAEDA
CCEEECCCCCCHHHH		33.3329136822
1201PhosphorylationSAIVEKSSPDAEDAV
CEEECCCCCCHHHHE		37.5629136822
1251AcetylationKRELEHEKLVGGGDL
HHHHHCCCCCCCCCC		50.8324489116
1262AcetylationGGDLPVDKEILNRAA
CCCCCCCHHHHHHHH		47.0624489116
1271PhosphorylationILNRAAQSLDSDQIK
HHHHHHHHCCHHHHH		29.4430377154
1320PhosphorylationQEETAFRTKDEQQSS
HHHCEEECHHHHHHH		36.0719779198
1321UbiquitinationEETAFRTKDEQQSSQ
HHCEEECHHHHHHHC		55.8223749301
1326PhosphorylationRTKDEQQSSQSNDSS
ECHHHHHHHCCCCCC		30.0019779198
1327PhosphorylationTKDEQQSSQSNDSSA
CHHHHHHHCCCCCCC		33.0319795423
1329PhosphorylationDEQQSSQSNDSSANA
HHHHHHCCCCCCCCC		44.5519795423
1332PhosphorylationQSSQSNDSSANASPT
HHHCCCCCCCCCCCC		35.2823749301
1333PhosphorylationSSQSNDSSANASPTT
HHCCCCCCCCCCCCC		28.5323749301
1337PhosphorylationNDSSANASPTTDPIS
CCCCCCCCCCCCCCC		23.6823749301
1339PhosphorylationSSANASPTTDPISTG
CCCCCCCCCCCCCCC		41.1419779198
1340PhosphorylationSANASPTTDPISTGS
CCCCCCCCCCCCCCC		43.0719779198
1344PhosphorylationSPTTDPISTGSNTSR
CCCCCCCCCCCCCCC		31.9119795423
1345PhosphorylationPTTDPISTGSNTSRT
CCCCCCCCCCCCCCC		45.4019795423
1347PhosphorylationTDPISTGSNTSRTND
CCCCCCCCCCCCCCC		36.7019795423
1349PhosphorylationPISTGSNTSRTNDNA
CCCCCCCCCCCCCCC		22.6819795423
1350PhosphorylationISTGSNTSRTNDNAH
CCCCCCCCCCCCCCC		41.1619795423
1395PhosphorylationKIQDARNSSTK----
HHHHHHHHCCC----		33.5623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MHP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MHP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MHP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PP12_YEASTGLC7physical
11805837
TBA1_YEASTTUB1genetic
9855114
TBB_YEASTTUB2genetic
9855114
GEM1_YEASTGEM1genetic
20093466
HAP3_YEASTHAP3genetic
20093466
GDT1_YEASTGDT1genetic
20093466
DER1_YEASTDER1genetic
20093466
SDS24_YEASTSDS24genetic
20093466
MTC4_YEASTMTC4genetic
20093466
DTD_YEASTDTD1genetic
20093466
ATG20_YEASTATG20genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
UBP3_YEASTUBP3genetic
20093466
PES4_YEASTPES4genetic
20093466
PHO4_YEASTPHO4genetic
20093466
SHE10_YEASTSHE10genetic
20093466
CGR1_YEASTCGR1genetic
20093466
SLH1_YEASTSLH1genetic
20093466
SPO11_YEASTSPO11genetic
20093466
YHA8_YEASTYHL008Cgenetic
20093466
SKN7_YEASTSKN7genetic
20093466
AIM21_YEASTAIM21genetic
20093466
YK58_YEASTYKR078Wgenetic
20093466
GST2_YEASTGTT2genetic
20093466
UBR2_YEASTUBR2genetic
20093466
PCD1_YEASTPCD1genetic
20093466
SMA2_YEASTSMA2genetic
20093466
YMS4_YEASTYMR034Cgenetic
20093466
AEP2_YEASTAEP2genetic
20093466
LSM7_YEASTLSM7genetic
20093466
MKT1_YEASTMKT1genetic
20093466
IRA2_YEASTIRA2genetic
20093466
PMG3_YEASTGPM3genetic
20093466
SHE4_YEASTSHE4genetic
20093466
CY1_YEASTCYT1genetic
20093466
SWT1_YEASTSWT1genetic
20093466
GSP2_YEASTGSP2genetic
20093466
TPO4_YEASTTPO4genetic
20093466
ACM1_YEASTACM1genetic
20093466
COX10_YEASTCOX10genetic
20093466
EF1G1_YEASTCAM1genetic
20093466
RAD1_YEASTRAD1genetic
20093466
CISY3_YEASTCIT3genetic
20093466
MDM36_YEASTMDM36genetic
20093466
THI22_YEASTTHI22genetic
20093466
QCR2_YEASTQCR2genetic
20093466
OPT2_YEASTOPT2genetic
20093466
RV161_YEASTRVS161genetic
23891562
CSG2_YEASTCSG2genetic
23891562
SWC4_YEASTSWC4genetic
27708008
COX7_YEASTCOX7genetic
27708008
SYIC_YEASTILS1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
PRP11_YEASTPRP11genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
RMRP_YEASTSNM1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
GEM1_YEASTGEM1genetic
27708008
CSG2_YEASTCSG2genetic
27708008
MCFS2_YEASTEHT1genetic
27708008
REI1_YEASTREI1genetic
27708008
RV161_YEASTRVS161genetic
27708008
NHP10_YEASTNHP10genetic
27708008
ATG20_YEASTATG20genetic
27708008
DTD_YEASTDTD1genetic
27708008
SAC3_YEASTSAC3genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
UBP3_YEASTUBP3genetic
27708008
ODPA_YEASTPDA1genetic
27708008
PHO4_YEASTPHO4genetic
27708008
CGR1_YEASTCGR1genetic
27708008
SHE10_YEASTSHE10genetic
27708008
ASK10_YEASTASK10genetic
27708008
SLH1_YEASTSLH1genetic
27708008
SPO11_YEASTSPO11genetic
27708008
COX23_YEASTCOX23genetic
27708008
FYV10_YEASTFYV10genetic
27708008
CBT1_YEASTCBT1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
COX12_YEASTCOX12genetic
27708008
SRN2_YEASTSRN2genetic
27708008
UBX2_YEASTUBX2genetic
27708008
BUL2_YEASTBUL2genetic
27708008
YMS4_YEASTYMR034Cgenetic
27708008
AEP2_YEASTAEP2genetic
27708008
SIW14_YEASTSIW14genetic
27708008
BRE5_YEASTBRE5genetic
27708008
HST3_YEASTHST3genetic
27708008
ODC2_YEASTODC2genetic
27708008
YO223_YEASTDSC3genetic
27708008
TPO4_YEASTTPO4genetic
27708008
EF1G1_YEASTCAM1genetic
27708008
ACM1_YEASTACM1genetic
27708008
YP097_YEASTYPR097Wgenetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MHP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174; SER-176; THR-577AND SER-1200, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174 AND SER-176, ANDMASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309 AND SER-311, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-222 AND THR-577, ANDMASS SPECTROMETRY.

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